FBXO7 and SKP1

Number of citations of the paper that reports this interaction (PMID 10531037)
93

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		FBXO7	SKP1
Gene Name		F-box protein 7	S-phase kinase-associated protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Mitochondrion Cytosol Protein Complex	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex PcG Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein Kinase Binding	Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Mitochondrion Degradation Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Mitochondrion Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Notch Signaling Pathway Circadian Rhythm Viral Process Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Histone H2A Monoubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by NOTCH1 HD Domain Mutants in Cancer Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Cyclin E associated events during G1/S transition Signaling by Wnt Regulation of PLK1 Activity at G2/M Transition Downstream signaling events of B Cell Receptor (BCR) Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Degradation of beta-catenin by the destruction complex G1/S Transition AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Signaling by NOTCH1 in Cancer Prolactin receptor signaling Mitotic G1-G1/S phases truncations of AMER1 destabilize the destruction complex Signaling by NOTCH Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Regulation of APC/C activators between G1/S and early anaphase S Phase Signaling by ERBB4 APC/C-mediated degradation of cell cycle proteins Signaling by Interleukins SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Interleukin-1 signaling Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G2-G2/M phases Constitutive Signaling by NOTCH1 PEST Domain Mutants Adaptive Immune System Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer HIV Infection APC truncation mutants have impaired AXIN binding G2/M Transition APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated Signaling by NOTCH1 Class I MHC mediated antigen processing & presentation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FBXW7 Mutants and NOTCH1 in Cancer Vpu mediated degradation of CD4 G1 Phase Cytokine Signaling in Immune system Cell Cycle, Mitotic NOTCH1 Intracellular Domain Regulates Transcription Cyclin D associated events in G1 Nuclear signaling by ERBB4 Activation of NF-kappaB in B cells SCF-beta-TrCP mediated degradation of Emi1 Regulation of mitotic cell cycle Signaling by Hedgehog deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Degradation of GLI1 by the proteasome Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS		Red blood cell traits ( 23222517)
Protein-Protein Interactions		13 interactors: BIRC2 CDC34 ELF4 PARK2 PINK1 PSMA3 PSME3 PSMF1 RBBP6 SEC24C SKP1 UBE2D2 XPO1	67 interactors: ANKRD36BP1 APIP BTRC CACYBP CCNA2 CDCA3 CDK2 CDK4 CDK9 CDKN1B CENPE CKS1B CTNNB1 CUL1 CUL7 DDX19B FBXL2 FBXL3 FBXL4 FBXL5 FBXL6 FBXL8 FBXO11 FBXO15 FBXO16 FBXO17 FBXO18 FBXO2 FBXO25 FBXO28 FBXO3 FBXO32 FBXO34 FBXO4 FBXO44 FBXO5 FBXO6 FBXO7 FBXO8 FBXO9 FBXW2 FBXW5 FBXW7 FBXW8 GLMN GPS1 HSP90AA1 KCTD9 LMO2 MED21 MYC NFKBIA NFKBIB NFKBIE NUDT9P1 PPP1CA RBX1 SKP2 SUGT1 TBL1X TERF1 TRRAP TTC21A TTC9C UBE2D1 UBE2D3 UHRF2
Entrez ID		25793	6500
HPRD ID		07292	03255
Ensembl ID		ENSG00000100225
Uniprot IDs		Q9Y3I1	P63208
PDB IDs			1FQV 1FS1 1FS2 1LDK 1P22 2ASS 2AST 2E31 2E32 2OVP 2OVQ 2OVR 3L2O 4I6J
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Protein Polyubiquitination Regulation Of Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Proteolysis Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Cellular Protein Modification Process Regulation Of Proteolysis Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Modification Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Protein Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Protein K48-linked Ubiquitination Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Protein Metabolic Process Mitotic Cell Cycle Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Signal Transduction Involved In DNA Damage Checkpoint	Protein Ubiquitination Protein Modification By Small Protein Conjugation SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Cell Cycle Cell Cycle Process Cellular Protein Modification Process Catabolic Process Cellular Protein Metabolic Process Regulation Of Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Protein Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Process Mitotic Cell Cycle Phase Transition Regulation Of Protein Metabolic Process Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Ubiquitination Cellular Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Protein Metabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Mitotic Cell Cycle Cell Division Regulation Of Ubiquitin-protein Transferase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Mitotic Nuclear Division Positive Regulation Of Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Transferase Activity
Tagcloud ?		atp13a2 autosomal called ceroid chilean dj elusive juvenile krs kufor levodopa lipofuscinoses named ncls neurodegeneration palsy park9 parkin parkinsonism pd pedigree pink1 pla2g6 pyramidal rakeb recessive supranuclear synuclein whereby	ankyrin attenuates bc belonging binds box collection degenerate elongation elongin hippel inhibiting initially interacting jak lindau motif multifunctional multiprotein participates pol repeat socs spry stat suppressor vhl von wd
Tagcloud (Difference) ?		atp13a2 autosomal called ceroid chilean dj elusive juvenile krs kufor levodopa lipofuscinoses named ncls neurodegeneration palsy park9 parkin parkinsonism pd pedigree pink1 pla2g6 pyramidal rakeb recessive supranuclear synuclein whereby	ankyrin attenuates bc belonging binds box collection degenerate elongation elongin hippel inhibiting initially interacting jak lindau motif multifunctional multiprotein participates pol repeat socs spry stat suppressor vhl von wd
Tagcloud (Intersection) ?