FBXO7 and XPO1

Number of citations of the paper that reports this interaction (PMID 21378169)
2

Data Source:
BioGRID (pull down)

		FBXO7	XPO1
Gene Name		F-box protein 7	exportin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Mitochondrion Cytosol Protein Complex	Kinetochore Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Ribonucleoprotein Complex Nuclear Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein Kinase Binding	RNA Binding Transporter Activity Nucleocytoplasmic Transporter Activity Protein Binding Ran GTPase Binding Protein Transporter Activity Protein Domain Specific Binding
	Biological Process	Mitochondrion Degradation Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Mitochondrion Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Protein Export From Nucleus Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Regulation Of Centrosome Duplication Viral Process Viral Life Cycle Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Localization To Nucleus Regulation Of Protein Catabolic Process Response To Drug Regulation Of Protein Export From Nucleus MRNA Transport Intracellular Transport Of Virus
Pathways			Loss of Function of TGFBR2 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Signaling by Wnt TGF-beta receptor signaling activates SMADs Influenza Life Cycle Export of Viral Ribonucleoproteins from Nucleus RNF mutants show enhanced WNT signaling and proliferation Regulation of mRNA stability by proteins that bind AU-rich elements TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Host Interactions of HIV factors Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Influenza Infection Late Phase of HIV Life Cycle Resolution of Sister Chromatid Cohesion Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Mitotic Prometaphase Separation of Sister Chromatids HIV Infection Rev-mediated nuclear export of HIV RNA G2/M Transition Mitotic Anaphase TGFBR1 LBD Mutants in Cancer HuR stabilizes mRNA deactivation of the beta-catenin transactivating complex M Phase HIV Life Cycle Rev-mediated nuclear export of HIV RNA Cyclin A/B1 associated events during G2/M transition XAV939 inhibits tankyrase, stabilizing AXIN NEP/NS2 Interacts with the Cellular Export Machinery Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Interactions of Rev with host cellular proteins Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer TCF dependent signaling in response to WNT Signaling by WNT in cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Red blood cell traits ( 23222517)
Protein-Protein Interactions		13 interactors: BIRC2 CDC34 ELF4 PARK2 PINK1 PSMA3 PSME3 PSMF1 RBBP6 SEC24C SKP1 UBE2D2 XPO1	72 interactors: ABL1 ADAR AGFG1 AHR ANP32A ANP32B APC ATF2 BECN1 BIRC5 CCND1 CDC25A CDCA4 CDKN1B CHEK1 CHORDC1 CIITA CRK DDX3X DR1 E2F4 E2F5 EIF5A ERF FBXO7 FOXO4 HDAC3 HNF4A HSPA9 IRF5 KIF17 MAPK6 NF2 NMD3 NPM1 NUCB1 NUCB2 NUP153 NUP214 NUP50 NUP62 NXF3 NXT1 ORC1 PHAX PHB PKIA PXN RAN RANBP1 RANBP2 RANBP3 RCC1 RCN2 RGS14 RIC8A RPS6KB1 SERPINB1 SERTAD2 SIRT2 SMAD1 SMARCB1 SMURF1 SNUPN SOX2 STAT1 STRADA TERF2IP TERT TOP2A TOP2B TP73
Entrez ID		25793	7514
HPRD ID		07292	03975
Ensembl ID		ENSG00000100225	ENSG00000082898
Uniprot IDs		Q9Y3I1	B3KWD0 O14980
PDB IDs			1W9C 2L1L 3GB8 4BSM 4BSN
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Protein Polyubiquitination Regulation Of Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Proteolysis Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Cellular Protein Modification Process Regulation Of Proteolysis Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Modification Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Protein Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Protein K48-linked Ubiquitination Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Protein Metabolic Process Mitotic Cell Cycle Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Signal Transduction Involved In DNA Damage Checkpoint	Cell Cycle Cell Cycle Process Nucleocytoplasmic Transport Mitotic Cell Cycle Nuclear Transport Mitotic Cell Cycle Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Metabolic Process Organelle Organization Cytoplasmic Transport Nuclear Export Positive Regulation Of Gene Expression Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Gene Expression Negative Regulation Of Kinase Activity Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Protein Export From Nucleus Intracellular Transport Response To Organic Substance Negative Regulation Of Phosphorylation RNA Transport RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Localization Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Protein Kinase Activity Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Cycle Negative Regulation Of Transferase Activity RNA Metabolic Process Negative Regulation Of Protein Phosphorylation Regulation Of Cellular Process Regulation Of Kinase Activity Regulation Of Cell Cycle Process Positive Regulation Of Transcription, DNA-templated Regulation Of Cell Proliferation Regulation Of Cellular Protein Metabolic Process Nitrogen Compound Metabolic Process Establishment Of Localization In Cell Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity
Tagcloud ?		atp13a2 autosomal called ceroid chilean dj elusive juvenile krs kufor levodopa lipofuscinoses named ncls neurodegeneration palsy park9 parkin parkinsonism pd pedigree pink1 pla2g6 pyramidal rakeb recessive supranuclear synuclein whereby	accounting atm bioinformatics birc3 concordance confirmation conservative cutoff discordant eventually haloplex hiseq ighv ighv3 klhl6 lymphocytic myd88 next notch1 pot1 precision recurrently repeating reproducible sanger sequencing sf3b1 stand unmutated
Tagcloud (Difference) ?		atp13a2 autosomal called ceroid chilean dj elusive juvenile krs kufor levodopa lipofuscinoses named ncls neurodegeneration palsy park9 parkin parkinsonism pd pedigree pink1 pla2g6 pyramidal rakeb recessive supranuclear synuclein whereby	accounting atm bioinformatics birc3 concordance confirmation conservative cutoff discordant eventually haloplex hiseq ighv ighv3 klhl6 lymphocytic myd88 next notch1 pot1 precision recurrently repeating reproducible sanger sequencing sf3b1 stand unmutated
Tagcloud (Intersection) ?