FBXO7 and FGF10

Number of citations of the paper that reports this interaction (PubMedID 27503909)
69

Data Source:
BioGRID (enzymatic study)

		FBXO7	FGF10
Description		F-box protein 7	fibroblast growth factor 10
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol SCF Ubiquitin Ligase Complex Protein-containing Complex Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Neurite Lewy Body Core Lewy Body Corona	Extracellular Region Extracellular Space Nucleus Cytoplasm Plasma Membrane Cell Surface
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Protein Heterodimerization Activity Ubiquitin-like Ligase-substrate Adaptor Activity	Fibroblast Growth Factor Receptor Binding Type 2 Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity
	Biological Process	Autophagy Of Mitochondrion Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Mitochondrion Regulation Of Neuron Projection Development Protein Ubiquitination Lymphocyte Differentiation Regulation Of Protein Stability Regulation Of Locomotion Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Lymphocyte Differentiation Protein K48-linked Ubiquitination Positive Regulation Of Mitophagy Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Autophagy Of Mitochondrion Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Angiogenesis Metanephros Development Organ Induction Mesonephros Development Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Blood Vessel Remodeling Metanephros Morphogenesis Chemotaxis Cell-cell Signaling Determination Of Left/right Symmetry Salivary Gland Development Salivary Gland Morphogenesis Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Regulation Of Smoothened Signaling Pathway Embryonic Pattern Specification Animal Organ Morphogenesis Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Keratinocyte Proliferation Wnt Signaling Pathway Pituitary Gland Development Neurogenesis Actin Cytoskeleton Organization Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Lung Development Regulation Of Cell Migration Embryonic Genitalia Morphogenesis Epithelial Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Thyroid Gland Development Otic Vesicle Formation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Pancreas Development Hair Follicle Morphogenesis Embryonic Camera-type Eye Development Response To Estradiol Response To Lipopolysaccharide Positive Regulation Of ATP-dependent Activity Lacrimal Gland Development Regulation Of Activin Receptor Signaling Pathway Protein Localization To Cell Surface Somatic Stem Cell Population Maintenance Limb Morphogenesis Organ Growth Wound Healing Tissue Regeneration Inner Ear Morphogenesis Odontogenesis Of Dentin-containing Tooth Muscle Cell Fate Commitment Positive Regulation Of MAPK Cascade Keratinocyte Proliferation Positive Regulation Of DNA Repair Positive Regulation Of Notch Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Ras Protein Signal Transduction Regulation Of Saliva Secretion Vascular Endothelial Growth Factor Receptor Signaling Pathway Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Blood Vessel Morphogenesis Spleen Development Thymus Development Embryonic Digestive Tract Morphogenesis Digestive Tract Development Embryonic Digestive Tract Development Animal Organ Formation Epidermis Morphogenesis Semicircular Canal Morphogenesis Branching Morphogenesis Of An Epithelial Tube Female Genitalia Morphogenesis Male Genitalia Morphogenesis Positive Regulation Of Lymphocyte Proliferation Epithelial Cell Proliferation Urothelial Cell Proliferation Positive Regulation Of Urothelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation White Fat Cell Differentiation Positive Chemotaxis Induction Of Positive Chemotaxis Smooth Muscle Cell Differentiation Positive Regulation Of Keratinocyte Migration Radial Glial Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Limb Development Limb Bud Formation Lung Morphogenesis Lung Epithelium Development Lung Saccule Development Bronchiole Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Bud Outgrowth Involved In Lung Branching Bud Elongation Involved In Lung Branching Mesenchymal-epithelial Cell Signaling Involved In Lung Development Type II Pneumocyte Differentiation Prostatic Bud Formation Respiratory System Development Mammary Gland Specification Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Mammary Gland Bud Formation Submandibular Salivary Gland Formation Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Branch Elongation Involved In Salivary Gland Morphogenesis Semicircular Canal Fusion Mesenchymal Cell Differentiation Involved In Lung Development Secretion By Lung Epithelial Cell Involved In Lung Growth Lung Proximal/distal Axis Specification Tear Secretion White Fat Cell Proliferation Positive Regulation Of White Fat Cell Proliferation ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Harderian Gland Development Positive Regulation Of Hair Follicle Cell Proliferation Stem Cell Proliferation Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Negative Regulation Of Stem Cell Proliferation Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	PI3K Cascade PIP3 activates AKT signaling FGFR1b ligand binding and activation FGFR2b ligand binding and activation Activated point mutants of FGFR2 Regulation of gene expression in early pancreatic precursor cells Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Signaling by FGFR2 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Developmental Lineage of Multipotent Pancreatic Progenitor Cells Developmental Lineage of Mammary Stem Cells
Drugs
Diseases		Parkinson's disease (PD)	Aplasia of lacrimal and salivary glands Lacrimo-auriculo-dento-digital syndrome (LADD); Levy-Hollister syndrome
GWAS		Mean corpuscular hemoglobin ( 27863252 29403010 32888494) Mean corpuscular volume ( 27863252 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252 32888494) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 32888494) Refractive error ( 32231278)	Alzheimer disease and age of onset ( 26830138) Basal cell carcinoma ( 31174203) Breast cancer ( 29059683 31757997) Dentures ( 31235808) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) High altitude adaptation ( 28373541) Keratinocyte cancer (MTAG) ( 31174203) Lung function (FVC) ( 30175238 30804560) Nonsyndromic cleft lip with cleft palate ( 28232668) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Parkinson's disease ( 26227905) Prostate cancer ( 21743467) Refractive error ( 32231278)
Interacting Genes		348 interacting genes: AATF ABCF3 ABL1 ACOT8 ACSL5 ACSM3 ACTC1 ACVR1 ACVR2B AK8 AKAP14 AKAP19 AKIRIN2 AKT3 ALKBH3 AMOTL2 ANGPTL7 ANKRD36BP1 ANP32E APEX1 APOBEC3C APOBEC4 ASPH ASPHD1 ATAT1 ATF5 ATP5F1C BAG3 BCKDK BIRC2 BLK BUB1 BUB1B C11orf16 C1orf105 C1orf115 C22orf31 CACYBP CAMK1 CAPN5 CASQ2 CCBE1 CCDC186 CCDC60 CCDC88C CCNE2 CDC34 CDK10 CDK14 CEP112 CFAP300 CHCHD2 CHCHD6 CHMP2B CHMP3 CILK1 CIRBP CKAP2 CLHC1 CLIP3 CMTR2 CNOT7 COLEC12 COXFA4L3 CPAP CPEB4 CRMA CSNK1E CXCL12 CXCL9 DDRGK1 DDX10 DHRS2 DHX40 DNAH14 DNAJA3 DNAJB12 DNAJC30 DPY19L2P1 DRAP1 ELF4 EP400P1 EPHA3 EPHB2 EPHB3 EPHB4 ERBB2 ERICH2 EYA2 FGF10 FGF13 FGFR1 FGFR2 FMOD FUT8 FYTTD1 GADD45GIP1 GAPDH GBP2 GEMIN2 GET4 GGA2 GLCE GLIPR2 GLRX2 GMCL2 GNLY GORAB GPAM GPKOW GRK6 GSK3B H1-0 H2AZ2 H3-3B HADH HMG20A HMG20B HMGB2 HMGCS2 HNRNPK HPF1 IDH2 IFT88 IGKV1-5 IL4 IL7 ILKAP INKA2 INPP5K INTS7 IPO9 IRF3 JADE2 KCNAB1 KCTD14 KHDRBS3 KIAA1586 KIF12 KIFC3 KIRREL3-AS3 KLF4 KMO KPNA5 LETMD1 LGALS3BP LIMK1 LIMK2 LINC01483 LMNA LRRC20 LRRC8E LRRFIP1 MAK MAP2K6 MAPK10 MAPK9 MAPRE2 MARK2 MARK3 MBD5 MBNL1 MCM2 MCM5 MDK MED22 MED27 MEF2D MEST MIS18BP1 MITF MMP13 MMP8 MNDA MOB3A MOB3C MPG MPP3 MPZL1 MRM3 MRPL27 MRPS14 MTIF3 MTUS1 MYOG NANS NDE1 NFIA NFIC NFKB1 NKD2 NPHP1 NUDT16L1 NUMB NVL ODF2L OLFML2A OR14K1 ORC3 OSTF1 PABPC3 PACRG PAFAH1B1 PAK6 PCBD2 PDCD7 PDE12 PDE4D PDGFB PGAP4 PHLDA1 PIEZO1 PIGY PIM1 PIM2 PINK1 PLEKHA1 PNOC PNRC2 POLDIP2 POLR2K PPHLN1 PPP1CB PPP1R17 PPP1R21 PRAME PRICKLE2 PRKACB PRKCA PRKCB PRKCG PRKN PRMT1 PRRC2B PUF60 PUSL1 QKI RBBP6 RBFOX2 RBM23 RBM33 RCC1 REEP3 REEP4 RET RGS1 RGS22 RNF121 RORB RPL14 RPL26 RPL36A RPL37A RPL3L RPL6 RPS15A RPS18 RPS19BP1 RPS2 RPS6KA3 RPS6KB1 RSL24D1 RWDD4 S100A13 S100A16 S100B SAMHD1 SCARA5 SDCCAG8 SEC16B SEC24C SET SFR1 SHANK3 SHMT1 SKP1 SLAIN1 SLC25A26 SLC35B3 SLC7A6OS SMARCD1 SMOC2 SNAP25 SNRPA SNX33 SPATA4 SPDYA SPRY2 SRCIN1 SRPK3 SRSF10 SRSF7 SS18L2 STAT6 STYX TAF9B TARDBP TBC1D3P2 TBPL1 TC2N TCP10L3 TEAD4 TEC TECR TECRL TENT5D TEX29 TGIF2 THAP7 TLE3 TMED10 TMEM120A TMEM237 TMOD2 TMPRSS5 TOMM20 TRAPPC12 TRIB3 TRIM44 TSBP1 TSLP TTC3 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2J2 UBE2M UROD USF1 USH1C UXS1 VPS16 VRK3 WDR18 WDR24 XPO1 XRN1 YPEL5 ZBTB44 ZC2HC1C ZFYVE21 ZKSCAN8 ZMYM5 ZNF462 ZNF574 ZNF684 ZNF688	6 interacting genes: FBXO7 FGFR1 FGFR2 POMC SREK1IP1 THAP1
Entrez ID		25793	2255
HPRD ID		07292	03665
Ensembl ID		ENSG00000100225	ENSG00000070193
Uniprot IDs		Q9Y3I1	O15520
PDB IDs		4L9C 4L9H	1NUN
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Protein Phosphorylation Nucleoplasm Nucleus Protein Serine Kinase Activity Transferase Activity Phosphorylation Macromolecule Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Nucleotide Binding Nuclear Membrane Organization Negative Regulation Of Apoptotic Process Phosphate-containing Compound Metabolic Process Regulation Of Microtubule-based Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Programmed Cell Death Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Macromolecule Metabolic Process F-box Domain Binding Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Primary Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Regulation Of Macromolecule Biosynthetic Process Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Cytoplasm Regulation Of Organelle Assembly Regulation Of Metabolic Process Nucleolus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Conjugating Enzyme Activity Structural Constituent Of Ribosome Nucleic Acid Metabolic Process Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Mitotic Cell Cycle Regulation Of Protein Metabolic Process RNA Binding B Cell Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Protein Localization Regulation Of Protein Modification Process	Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Ventricular Zone Neuroblast Division Orbitofrontal Cortex Development Positive Regulation Of Phospholipase Activity Fibroblast Growth Factor Receptor Activity Forebrain Neuroblast Division Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of Lipase Activity Lung-associated Mesenchyme Development Branching Involved In Salivary Gland Morphogenesis Fibroblast Growth Factor Binding Mesenchymal Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Gland Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Midbrain Development Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Heart Growth Response To Fibroblast Growth Factor Ureteric Bud Development Regulation Of Cardiac Muscle Cell Proliferation Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Organ Growth Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Morphogenesis Of A Branching Structure Mesenchyme Development Inner Ear Morphogenesis Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Cycle Regulation Of Heart Growth Kidney Epithelium Development Positive Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Parathyroid Hormone Secretion Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Cell Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Positive Regulation Of Oxytocin Production Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Epithelial To Mesenchymal Transition Biomineral Tissue Development Regulation Of Organ Growth Regulation Of Mitotic Cell Cycle Lung Development Stem Cell Differentiation
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