FBXO7 and TMPRSS5

Number of citations: 69 (PubMedID 27503909)
Data Source: BioGRID (enzymatic study)

		FBXO7	TMPRSS5
Name		F-box protein 7	transmembrane serine protease 5
Structure			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol SCF Ubiquitin Ligase Complex Protein-containing Complex Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Neurite Lewy Body Core Lewy Body Corona	Plasma Membrane Membrane Neuronal Cell Body
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Protein Heterodimerization Activity Ubiquitin-like Ligase-substrate Adaptor Activity	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Autophagy Of Mitochondrion Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Mitochondrion Regulation Of Neuron Projection Development Protein Ubiquitination Lymphocyte Differentiation Regulation Of Protein Stability Regulation Of Locomotion Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Lymphocyte Differentiation Protein K48-linked Ubiquitination Positive Regulation Of Mitophagy Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Autophagy Of Mitochondrion Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Proteolysis
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	None
Diseases		Parkinson's disease (PD)	None
GWAS		Mean corpuscular hemoglobin ( 27863252 29403010 32888494 ) Mean corpuscular volume ( 27863252 29403010 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell count ( 27863252 32888494 ) Red blood cell traits ( 23222517 ) Red cell distribution width ( 27863252 32888494 ) Refractive error ( 32231278 )	Age-related nuclear cataracts ( 33311586 ) Chronic lymphocytic leukemia ( 28165464 ) Chronotype ( 30696823 ) Feeling guilty ( 29500382 ) Height ( 28552196 ) Interferon alpha levels in systemic lupus erythematosus ( 25338677 ) Neurological blood protein biomarker levels ( 31320639 ) Pursuit maintenance gain ( 29064472 ) Pursuit maintenance gain in psychotic disorders ( 29064472 ) Smoking cessation ( 33082346 ) Smoking status (current vs mixed) ( 33082346 ) Smoking status (current vs never) ( 33082346 ) Worry too long after an embarrassing experience ( 29500382 )
Interacting Genes		348 interacting genes: AATF ABCF3 ABL1 ACOT8 ACSL5 ACSM3 ACTC1 ACVR1 ACVR2B AK8 AKAP14 AKAP19 AKIRIN2 AKT3 ALKBH3 AMOTL2 ANGPTL7 ANKRD36BP1 ANP32E APEX1 APOBEC3C APOBEC4 ASPH ASPHD1 ATAT1 ATF5 ATP5F1C BAG3 BCKDK BIRC2 BLK BUB1 BUB1B C11orf16 C1orf105 C1orf115 C22orf31 CACYBP CAMK1 CAPN5 CASQ2 CCBE1 CCDC186 CCDC60 CCDC88C CCNE2 CDC34 CDK10 CDK14 CEP112 CFAP300 CHCHD2 CHCHD6 CHMP2B CHMP3 CILK1 CIRBP CKAP2 CLHC1 CLIP3 CMTR2 CNOT7 COLEC12 COXFA4L3 CPAP CPEB4 CRMA CSNK1E CXCL12 CXCL9 DDRGK1 DDX10 DHRS2 DHX40 DNAH14 DNAJA3 DNAJB12 DNAJC30 DPY19L2P1 DRAP1 ELF4 EP400P1 EPHA3 EPHB2 EPHB3 EPHB4 ERBB2 ERICH2 EYA2 FGF10 FGF13 FGFR1 FGFR2 FMOD FUT8 FYTTD1 GADD45GIP1 GAPDH GBP2 GEMIN2 GET4 GGA2 GLCE GLIPR2 GLRX2 GMCL2 GNLY GORAB GPAM GPKOW GRK6 GSK3B H1-0 H2AZ2 H3-3B HADH HMG20A HMG20B HMGB2 HMGCS2 HNRNPK HPF1 IDH2 IFT88 IGKV1-5 IL4 IL7 ILKAP INKA2 INPP5K INTS7 IPO9 IRF3 JADE2 KCNAB1 KCTD14 KHDRBS3 KIAA1586 KIF12 KIFC3 KIRREL3-AS3 KLF4 KMO KPNA5 LETMD1 LGALS3BP LIMK1 LIMK2 LINC01483 LMNA LRRC20 LRRC8E LRRFIP1 MAK MAP2K6 MAPK10 MAPK9 MAPRE2 MARK2 MARK3 MBD5 MBNL1 MCM2 MCM5 MDK MED22 MED27 MEF2D MEST MIS18BP1 MITF MMP13 MMP8 MNDA MOB3A MOB3C MPG MPP3 MPZL1 MRM3 MRPL27 MRPS14 MTIF3 MTUS1 MYOG NANS NDE1 NFIA NFIC NFKB1 NKD2 NPHP1 NUDT16L1 NUMB NVL ODF2L OLFML2A OR14K1 ORC3 OSTF1 PABPC3 PACRG PAFAH1B1 PAK6 PCBD2 PDCD7 PDE12 PDE4D PDGFB PGAP4 PHLDA1 PIEZO1 PIGY PIM1 PIM2 PINK1 PLEKHA1 PNOC PNRC2 POLDIP2 POLR2K PPHLN1 PPP1CB PPP1R17 PPP1R21 PRAME PRICKLE2 PRKACB PRKCA PRKCB PRKCG PRKN PRMT1 PRRC2B PUF60 PUSL1 QKI RBBP6 RBFOX2 RBM23 RBM33 RCC1 REEP3 REEP4 RET RGS1 RGS22 RNF121 RORB RPL14 RPL26 RPL36A RPL37A RPL3L RPL6 RPS15A RPS18 RPS19BP1 RPS2 RPS6KA3 RPS6KB1 RSL24D1 RWDD4 S100A13 S100A16 S100B SAMHD1 SCARA5 SDCCAG8 SEC16B SEC24C SET SFR1 SHANK3 SHMT1 SKP1 SLAIN1 SLC25A26 SLC35B3 SLC7A6OS SMARCD1 SMOC2 SNAP25 SNRPA SNX33 SPATA4 SPDYA SPRY2 SRCIN1 SRPK3 SRSF10 SRSF7 SS18L2 STAT6 STYX TAF9B TARDBP TBC1D3P2 TBPL1 TC2N TCP10L3 TEAD4 TEC TECR TECRL TENT5D TEX29 TGIF2 THAP7 TLE3 TMED10 TMEM120A TMEM237 TMOD2 TMPRSS5 TOMM20 TRAPPC12 TRIB3 TRIM44 TSBP1 TSLP TTC3 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2J2 UBE2M UROD USF1 USH1C UXS1 VPS16 VRK3 WDR18 WDR24 XPO1 XRN1 YPEL5 ZBTB44 ZC2HC1C ZFYVE21 ZKSCAN8 ZMYM5 ZNF462 ZNF574 ZNF684 ZNF688	1 interacting genes: FBXO7
Entrez ID		25793	80975
HPRD ID		07292	05995
Ensembl ID		ENSG00000100225	ENSG00000166682
Uniprot IDs		Q9Y3I1	B7Z247 F5GX83 F5GYA3 F5H0U3 F5H2M3 Q0P513 Q0P514 Q9H3S3
PDB IDs		4L9C 4L9H	Not available
GO Terms Enriched among Interactors		Protein Kinase Activity Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Protein Phosphorylation Nucleoplasm Nucleus Protein Serine Kinase Activity Transferase Activity Phosphorylation Macromolecule Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Nucleotide Binding Nuclear Membrane Organization Negative Regulation Of Apoptotic Process Phosphate-containing Compound Metabolic Process Regulation Of Microtubule-based Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Programmed Cell Death Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Macromolecule Metabolic Process F-box Domain Binding Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Primary Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Regulation Of Macromolecule Biosynthetic Process Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Cytoplasm Regulation Of Organelle Assembly Regulation Of Metabolic Process Nucleolus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Conjugating Enzyme Activity Structural Constituent Of Ribosome Nucleic Acid Metabolic Process Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Mitotic Cell Cycle Regulation Of Protein Metabolic Process RNA Binding B Cell Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Protein Localization Regulation Of Protein Modification Process	Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Lewy Body Core Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Protein Targeting To Mitochondrion Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitophagy Establishment Of Protein Localization To Mitochondrion Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Autophagy Of Mitochondrion Autophagy Of Mitochondrion SCF Ubiquitin Ligase Complex Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Complex Positive Regulation Of Macroautophagy Protein K48-linked Ubiquitination Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Ubiquitin Binding Negative Regulation Of Hemopoiesis Negative Regulation Of Lymphocyte Activation Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Autophagy Negative Regulation Of Neuron Apoptotic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Activation Protein Targeting Regulation Of Lymphocyte Differentiation Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Macroautophagy Negative Regulation Of Leukocyte Activation Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Lymphocyte Differentiation Ubiquitin-protein Transferase Activity