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C7orf25 and FYN
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
C7orf25
FYN
Gene Name
chromosome 7 open reading frame 25
FYN proto-oncogene, Src family tyrosine kinase
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Mitochondrion
Endosome
Cytosol
Actin Filament
Plasma Membrane
Postsynaptic Density
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Membrane Raft
Molecular Function
G-protein Coupled Receptor Binding
Glycoprotein Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Tubulin Binding
T Cell Receptor Binding
CD4 Receptor Binding
CD8 Receptor Binding
Phosphatidylinositol 3-kinase Binding
Ion Channel Binding
Metal Ion Binding
Ephrin Receptor Binding
Peptide Hormone Receptor Binding
Growth Factor Receptor Binding
Biological Process
Neuron Migration
Protein Phosphorylation
Calcium Ion Transport
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Axon Guidance
Central Nervous System Development
Blood Coagulation
Learning
Feeding Behavior
Regulation Of Cell Shape
Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Gene Expression
Positive Regulation Of Neuron Projection Development
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Cell Migration
Cell Differentiation
Platelet Activation
Forebrain Development
T Cell Costimulation
Intracellular Signal Transduction
Cellular Response To Platelet-derived Growth Factor Stimulus
Peptidyl-tyrosine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
T Cell Activation
Regulation Of Cell Proliferation
Negative Regulation Of Protein Catabolic Process
Response To Drug
Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Neuron Apoptotic Process
Innate Immune Response
Response To Ethanol
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Dendrite Morphogenesis
Regulation Of Defense Response To Virus By Virus
Activated T Cell Proliferation
T Cell Receptor Signaling Pathway
Leukocyte Migration
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
Cellular Response To Peptide Hormone Stimulus
Positive Regulation Of Protein Localization To Nucleus
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Signaling by the B Cell Receptor (BCR)
Signaling by FGFR in disease
DCC mediated attractive signaling
Netrin mediated repulsion signals
Signaling by EGFRvIII in Cancer
Nef and signal transduction
Signaling by SCF-KIT
DAP12 signaling
Downstream signaling events of B Cell Receptor (BCR)
Regulation of KIT signaling
PI3K/AKT activation
PI-3K cascade
EPH-Ephrin signaling
Fcgamma receptor (FCGR) dependent phagocytosis
FCGR activation
Signaling by PDGF
DAP12 interactions
GAB1 signalosome
Host Interactions of HIV factors
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
The role of Nef in HIV-1 replication and disease pathogenesis
Signaling by ERBB4
Constitutive PI3K/AKT Signaling in Cancer
Role of LAT2/NTAL/LAB on calcium mobilization
PI3K events in ERBB4 signaling
Signaling by ERBB2
Signaling by EGFR
Signaling by Interleukins
Signaling by VEGF
Downstream signal transduction
Sema3A PAK dependent Axon repulsion
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
Nephrin interactions
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
PI3K/AKT Signaling in Cancer
Platelet activation, signaling and aggregation
Interleukin-3, 5 and GM-CSF signaling
Adaptive Immune System
Platelet Adhesion to exposed collagen
Axon guidance
Costimulation by the CD28 family
PIP3 activates AKT signaling
HIV Infection
VEGFA-VEGFR2 Pathway
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
Ephrin signaling
EPH-ephrin mediated repulsion of cells
PI3K events in ERBB2 signaling
Regulation of signaling by CBL
Downstream signaling of activated FGFR
NCAM signaling for neurite out-growth
Netrin-1 signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Innate Immune System
Signalling by NGF
Semaphorin interactions
CTLA4 inhibitory signaling
Cytokine Signaling in Immune system
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Signaling by Overexpressed Wild-Type EGFR in Cancer
PECAM1 interactions
CD28 dependent Vav1 pathway
Signaling by FGFR
Cell surface interactions at the vascular wall
GPVI-mediated activation cascade
Drugs
Dasatinib
1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane
Diseases
GWAS
Inflammatory bowel disease (
23128233
)
Protein-Protein Interactions
18 interactors:
BRD4
CEP70
CRYM
DACT1
EZH2
FRA10AC1
FYN
FZR1
HAP1
HEXDC
MTOR
NGEF
PTN
RASSF1
RPL36AL
SF3B2
TARS
UBE2D1
182 interactors:
ACP1
ADAM15
ADD2
ARHGAP32
ARHGAP33
ATXN1
BCAR1
BCL3
BTK
C7orf25
C8orf33
CASP3
CASP8
CAV1
CBL
CBLB
CBLC
CD19
CD2
CD226
CD247
CD2AP
CD36
CD44
CD48
CD5
CD55
CD79A
CD79B
CDH1
CDK1
CDK5
CLTC
CMA1
CNN1
CNN3
CNTN1
CNTNAP1
CRK
CSF1R
CSF2RB
CSK
CTLA4
CTNNB1
CTNND2
DAG1
DLG4
DOK1
DOK3
DOK4
EFS
ENO1
EPHA3
EPHA4
EPHA8
EPHB3
EVL
FAS
FASLG
FCER2
FCGR2A
FLOT1
FLOT2
FLT1
FNBP4
FYB
GAB3
GNB2L1
GP6
GRAP
GRB10
GRB2
GRIN1
GRIN2A
GRIN2B
HNRNPK
HRAS
HSP90AA1
HTR6
IL1B
IL2RB
IL7R
IRS1
ITCH
ITGB4
ITK
ITPR1
JAK2
JUP
KDM1A
KDR
KHDRBS1
KIT
LAT
LCP2
MAG
MAP2
MAPT
MCAM
MED28
MS4A1
NCAM1
NEDD4
NEDD9
NMT1
NPHS1
NR3C1
NTRK2
PAG1
PAK2
PDE4D
PDGFRB
PECAM1
PIK3R1
PIK3R2
PLAUR
PLCG1
PLCG2
PLD2
PRKCD
PRKCE
PRKCH
PRKCQ
PRKCZ
PRMT6
PTK2
PTK2B
PTPN11
PTPN5
PTPRA
PTPRC
PTPRE
PTPRF
PTPRZ1
PXN
RAF1
RPL10
SDC3
SH2B2
SH2D1A
SH3BP2
SHC1
SIT1
SKAP1
SKAP2
SLAMF1
SNCA
SOCS1
SOS1
SPHK1
SPHK2
SPN
STAT1
STAT3
SUV39H1
SYK
TCAP
THY1
TNF
TNK2
TNNT1
TOM1L1
TRAF6
TRAT1
TRPC6
TRPV4
TUBA1B
TUBA3C
TUBA4A
TXK
TYK2
TYRO3
UHRF2
UNC119
VAV1
VAV2
WAS
WASF1
WASF2
WBP11
YTHDC1
ZAP70
Entrez ID
79020
2534
HPRD ID
09861
00655
Ensembl ID
ENSG00000136197
ENSG00000010810
Uniprot IDs
Q9BPX7
P06241
Q5R3A8
PDB IDs
1A0N
1AOT
1AOU
1AVZ
1AZG
1EFN
1FYN
1G83
1M27
1NYF
1NYG
1SHF
1ZBJ
2DQ7
3H0F
3H0H
3H0I
3UA6
3UA7
4D8D
4EIK
Enriched GO Terms of Interacting Partners
?
Regulation Of Cell Cycle Process
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle
Cell Cycle Process
Regulation Of Protein Metabolic Process
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Cell Cycle
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Cellular Response To Stress
Regulation Of Intracellular Signal Transduction
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Protein Ubiquitination
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Protein Catabolic Process
Mitotic Cell Cycle
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Metabolic Process
Regulation Of Cellular Component Organization
Cellular Response To DNA Damage Stimulus
Positive Regulation Of Cell Differentiation
Posttranscriptional Regulation Of Gene Expression
Regulation Of Cell Morphogenesis
Regulation Of Protein Localization To Nucleus
Regulation Of Cell Projection Organization
Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Positive Regulation Of Protein Modification Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Cell Differentiation
Regulation Of DNA-templated Transcription, Elongation
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Division
Positive Regulation Of Neurotrophin Production
Regulation Of Carbohydrate Utilization
Positive Regulation Of Nonmotile Primary Cilium Assembly
Positive Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Positive Regulation Of Cellular Protein Metabolic Process
Signaling
Signal Transduction
Cell Communication
Regulation Of Immune System Process
Response To Stimulus
Cellular Response To Stimulus
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Immune System Process
Regulation Of Immune Response
Enzyme Linked Receptor Protein Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Positive Regulation Of Immune System Process
Locomotion
Regulation Of Signal Transduction
Regulation Of Signaling
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response
Movement Of Cell Or Subcellular Component
Positive Regulation Of Immune Response
Defense Response
Positive Regulation Of Signal Transduction
Innate Immune Response
Cell Activation
Blood Coagulation
Antigen Receptor-mediated Signaling Pathway
Hemostasis
Fc Receptor Signaling Pathway
Response To Wounding
Response To Stress
Wound Healing
Response To Organic Substance
Cell Migration
Cell Differentiation
Intracellular Signal Transduction
Cell Motility
Regulation Of Body Fluid Levels
Response To External Stimulus
Regulation Of Cellular Process
Developmental Process
Regulation Of Cell-cell Adhesion
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Adhesion
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cellular Response To Organic Substance
Regulation Of Phosphorylation
Anatomical Structure Development
Regulation Of Cell Activation
Regulation Of Cellular Component Organization
Tagcloud
?
293t
analyzing
anchoring
aspartate
binds
coclusters
coexpressed
family
implicated
involves
learning
lyn
mediate
member
nmda
nr2a
participates
plasticity
promotes
psd
ptk
ptks
scaffold
serving
src
substrate
synaptic
tyrosine
yes
Tagcloud (Difference)
?
293t
analyzing
anchoring
aspartate
binds
coclusters
coexpressed
family
implicated
involves
learning
lyn
mediate
member
nmda
nr2a
participates
plasticity
promotes
psd
ptk
ptks
scaffold
serving
src
substrate
synaptic
tyrosine
yes
Tagcloud (Intersection)
?