SEPT2 and SEPT5

Number of citations of the paper that reports this interaction (PMID 10321247)
62

Data Source:
HPRD (in vitro, in vivo)

		SEPT2	SEPT5
Gene Name		septin 2	septin 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Exocyst Condensed Chromosome Kinetochore Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle Cell Cortex Actin Cytoskeleton Midbody Cleavage Furrow Ciliary Transition Zone Synapse Perinuclear Region Of Cytoplasm Ciliary Membrane Extracellular Vesicular Exosome	Cytoskeleton Plasma Membrane Cell Cortex Synaptic Vesicle Terminal Bouton
	Molecular Function	Protein Binding GTP Binding Enzyme Regulator Activity Protein Complex Scaffold	GTPase Activity Structural Molecule Activity Protein Binding GTP Binding
	Biological Process	Regulation Of L-glutamate Transport Mitotic Nuclear Division Smoothened Signaling Pathway Neuron Projection Development Regulation Of Protein Localization Cilium Assembly Regulation Of Catalytic Activity Cell Division	Cytokinesis Metabolic Process Synaptic Vesicle Targeting Regulation Of Exocytosis Regulation Of Synaptic Vesicle Exocytosis
Pathways		Organelle biogenesis and maintenance Assembly of the primary cilium Anchoring of the basal body to the plasma membrane
Drugs
Diseases
GWAS		Height ( 20881960)	DNA methylation (parent-of-origin) ( 23725790)
Protein-Protein Interactions		13 interactors: COG4 CSNK2A1 DAZAP2 HN1L MTOR PIK3R2 PLEKHF2 S100A4 SEPT5 SEPT6 SEPT9 STMN1 STX1A	18 interactors: APP KAT7 LSM8 MAGEA2B MAPK6 MYOG PARK2 PFN2 SEPT1 SEPT10 SEPT11 SEPT2 SEPT4 SEPT6 SEPT7 SEPT8 STX1A STX4
Entrez ID		4735	5413
HPRD ID		03297	04100
Ensembl ID		ENSG00000168385	ENSG00000184702
Uniprot IDs		B5MCX3 Q15019	G3XAH0 Q99719
PDB IDs		2QA5 2QAG 2QNR
Enriched GO Terms of Interacting Partners?		Regulation Of Synaptic Vesicle Exocytosis Regulation Of Synaptic Vesicle Transport Cell Cycle Synaptic Vesicle Exocytosis Regulation Of Protein Complex Assembly Regulation Of Neurotransmitter Secretion Regulation Of Carbohydrate Utilization Golgi Vesicle Prefusion Complex Stabilization Regulation Of Transcription Factor Import Into Nucleus Cell Division Regulation Of Cellular Localization Cell Cycle Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Autophagy Cytokinesis Neurotransmitter Secretion Synaptic Vesicle Transport Regulation Of Signaling Phosphatidylinositol-mediated Signaling Regulation Of Neurotransmitter Levels Insulin Receptor Signaling Pathway Regulation Of Exocytosis Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Transport ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Neurotransmitter Transport Regulation Of Protein Import Into Nucleus Vesicle-mediated Transport Regulation Of Establishment Of Protein Localization Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of NFAT Protein Import Into Nucleus Synaptic Vesicle Targeting Regulation Of Protein Localization To Nucleus Cell Morphogenesis Involved In Differentiation Establishment Of Vesicle Localization Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Regulation Of Nucleocytoplasmic Transport Vesicle Localization Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase III Promoter Microtubule Depolymerization Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Localization Synaptic Vesicle Fusion To Presynaptic Membrane Negative Regulation Of Macroautophagy	Cell Cycle Cell Division Regulation Of Synaptic Vesicle Transport Regulation Of Neurotransmitter Secretion Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Synaptic Transmission Positive Regulation Of Protein Ubiquitination Regulation Of Vesicle-mediated Transport Regulation Of Neurotransmitter Levels Regulation Of Exocytosis Neurotransmitter Transport Regulation Of Synaptic Vesicle Exocytosis Regulation Of Insulin Secretion Regulation Of Protein Ubiquitination Regulation Of Peptide Hormone Secretion Vesicle Fusion Synaptic Vesicle Exocytosis Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Muscle Atrophy Positive Regulation Of Mitochondrial Fusion Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Hormone Secretion Positive Regulation Of Exocytosis Organelle Organization Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Secretion Organelle Fusion Sperm Mitochondrion Organization Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Synaptic Growth At Neuromuscular Junction Positive Regulation Of Eosinophil Degranulation Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Embryonic Cell Shape Positive Regulation Of Protein Metabolic Process Vesicle Docking Cellular Component Assembly Exocytosis Regulation Of Cellular Component Organization Membrane Docking Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine Dopamine Uptake Involved In Synaptic Transmission Collateral Sprouting In Absence Of Injury Regulation Of Protein Localization Regulation Of Protein Secretion Cytokinesis Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of L-glutamate Transport Neurotransmitter Secretion
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