SEPT2 and STX1A

Number of citations of the paper that reports this interaction (PMID 10321247)
62

Data Source:
HPRD (in vivo, in vitro)

		SEPT2	STX1A
Gene Name		septin 2	syntaxin 1A (brain)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Exocyst Condensed Chromosome Kinetochore Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle Cell Cortex Actin Cytoskeleton Midbody Cleavage Furrow Ciliary Transition Zone Synapse Perinuclear Region Of Cytoplasm Ciliary Membrane Extracellular Vesicular Exosome	Extracellular Region Cytosol Plasma Membrane Synaptic Vesicle Endomembrane System Integral Component Of Membrane Cell Junction Secretory Granule Synaptic Vesicle Membrane SNARE Complex Actomyosin Neuron Projection Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex
	Molecular Function	Protein Binding GTP Binding Enzyme Regulator Activity Protein Complex Scaffold	SNARE Binding Glycoprotein Binding SNAP Receptor Activity Protein Binding Myosin Binding Calcium Channel Inhibitor Activity Chloride Channel Inhibitor Activity Kinase Binding Protein Domain Specific Binding Protein Binding, Bridging Myosin Head/neck Binding ATP-dependent Protein Binding Protein Heterodimerization Activity Protein N-terminus Binding Calcium-dependent Protein Binding
	Biological Process	Regulation Of L-glutamate Transport Mitotic Nuclear Division Smoothened Signaling Pathway Neuron Projection Development Regulation Of Protein Localization Cilium Assembly Regulation Of Catalytic Activity Cell Division	Positive Regulation Of Neurotransmitter Secretion Energy Reserve Metabolic Process Intracellular Protein Transport Synaptic Transmission Neurotransmitter Secretion Pathogenesis Response To Gravity Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Docking Calcium Ion-dependent Exocytosis Synaptic Vesicle Fusion To Presynaptic Membrane Secretion By Cell Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Exocytosis Vesicle Docking Regulation Of Insulin Secretion Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways		Organelle biogenesis and maintenance Assembly of the primary cilium Anchoring of the basal body to the plasma membrane	Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Toxicity of botulinum toxin type C (BoNT/C) Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Peptide hormone metabolism Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Insulin processing Serotonin Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Height ( 20881960)
Protein-Protein Interactions		13 interactors: COG4 CSNK2A1 DAZAP2 HN1L MTOR PIK3R2 PLEKHF2 S100A4 SEPT5 SEPT6 SEPT9 STMN1 STX1A	58 interactors: ABCC9 APBA1 ATP4B ATP6V1B1 CACNA1D CCSER2 CDK5 CFTR CPLX1 CSNK2A1 CSNK2A2 DAPK1 KCNB1 NAPA NAPB NSF PSMA3 RAB27A RIMS1 SCNN1A SCNN1B SCNN1G SDCBP SEPT2 SEPT5 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9 SNAP23 SNAP25 SNAP29 SNPH STX8 STXBP1 STXBP2 STXBP5 STXBP6 SUMO1P1 SYT1 SYT4 SYT7 SYTL4 TRDMT1 TXLNA TXLNB UNC13B VAMP1 VAMP2 VAMP5 VAMP7 VAMP8 VAPB VIM VPS11 VPS18
Entrez ID		4735	6804
HPRD ID		03297	01721
Ensembl ID		ENSG00000168385	ENSG00000106089
Uniprot IDs		B5MCX3 Q15019	A8MZ54 Q16623 Q75ME0
PDB IDs		2QA5 2QAG 2QNR
Enriched GO Terms of Interacting Partners?		Regulation Of Synaptic Vesicle Exocytosis Regulation Of Synaptic Vesicle Transport Cell Cycle Synaptic Vesicle Exocytosis Regulation Of Protein Complex Assembly Regulation Of Neurotransmitter Secretion Regulation Of Carbohydrate Utilization Golgi Vesicle Prefusion Complex Stabilization Regulation Of Transcription Factor Import Into Nucleus Cell Division Regulation Of Cellular Localization Cell Cycle Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Autophagy Cytokinesis Neurotransmitter Secretion Synaptic Vesicle Transport Regulation Of Signaling Phosphatidylinositol-mediated Signaling Regulation Of Neurotransmitter Levels Insulin Receptor Signaling Pathway Regulation Of Exocytosis Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Transport ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Neurotransmitter Transport Regulation Of Protein Import Into Nucleus Vesicle-mediated Transport Regulation Of Establishment Of Protein Localization Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of NFAT Protein Import Into Nucleus Synaptic Vesicle Targeting Regulation Of Protein Localization To Nucleus Cell Morphogenesis Involved In Differentiation Establishment Of Vesicle Localization Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Regulation Of Nucleocytoplasmic Transport Vesicle Localization Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase III Promoter Microtubule Depolymerization Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Localization Synaptic Vesicle Fusion To Presynaptic Membrane Negative Regulation Of Macroautophagy	Exocytosis Secretion By Cell Neurotransmitter Transport Secretion Regulation Of Exocytosis Regulation Of Neurotransmitter Levels Transport Vesicle-mediated Transport Regulation Of Secretion Neurotransmitter Secretion Synaptic Transmission Cell-cell Signaling Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Synaptic Vesicle Transport Synaptic Vesicle Exocytosis Cellular Localization Positive Regulation Of Exocytosis Regulation Of Cellular Localization Membrane Fusion Glutamate Secretion Establishment Of Vesicle Localization Vesicle Localization Ion Transport Vesicle Fusion Protein Transport Establishment Of Protein Localization Amino Acid Transport Vesicle Docking Organelle Fusion Membrane Docking Establishment Of Organelle Localization Membrane Organization Acid Secretion Vesicle Organization Positive Regulation Of Secretion Organelle Localization Protein Localization Monovalent Inorganic Cation Transport Anion Transport Dicarboxylic Acid Transport Regulated Secretory Pathway Metal Ion Transport Vesicle Docking Involved In Exocytosis Positive Regulation Of Transport Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Sodium Ion Transport Organic Anion Transport
Tagcloud ?			colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence
Tagcloud (Difference) ?			colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence
Tagcloud (Intersection) ?