HYPK and NEDD8

Number of citations of the paper that reports this interaction (PubMedID 34836490)
106

Data Source:
BioGRID (affinity chromatography technology, pull down)

		HYPK	NEDD8
Description		huntingtin interacting protein K	NEDD8 ubiquitin like modifier
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Folding Chaperone	Protein Binding Protein Tag Activity Ubiquitin Protein Ligase Binding
	Biological Process	Protein Folding Negative Regulation Of Apoptotic Process Protein Stabilization	Regulation Of Transcription By RNA Polymerase II Proteolysis Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Localization Anatomical Structure Morphogenesis Protein Ubiquitination Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Protein Modification Process Protein Neddylation Cellular Response To Camptothecin Regulation Of Postsynapse Assembly
Pathways			TGF-beta receptor signaling activates SMADs UCH proteinases Cargo recognition for clathrin-mediated endocytosis Neddylation Iron uptake and transport
Drugs
Diseases
GWAS			Mean corpuscular volume ( 29403010) Systolic blood pressure (cigarette smoking interaction) ( 26752167)
Interacting Genes		31 interacting genes: BOLL C2orf68 CSNK2B CYSRT1 HNRNPF HTT KRTAP12-2 KRTAP19-5 KRTAP3-2 KRTAP3-3 KRTAP8-1 MAGEA1 MAP1LC3B MDFI NAA10 NAA15 NEDD8 PCBP1 PHC3 PRR20A PRR20B PRR20C PRR20D PRR20E RBFOX1 RHOXF2 SP4 TENT5A THAP1 TXLNA VENTX	71 interacting genes: AHR ANKRD13D ARIH2 ATXN3 BAG3 CBLB CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B DNAJA2 DNAJB2 DNMT3B EIF3I FAF1 GARS1 GHR GRN GTF3C3 HDAC6 HGS HIF1A HSPA1B HSPA4 HSPA4L HSPA8 HSPA9 HSPH1 HYPK KLHDC2 N4BP1 NAE1 NSFL1C NUB1 NXPH2 OLFML2B OTUB1 OTUB2 OTUD5 OTUD6B PARP1 PCNA POLI PPP1CA PRKN PSMA6 PSMD4 PTK2 RAD23A SENP8 SET SIRT1 SMURF1 SQSTM1 TOLLIP TP53 TUBB4B UBA2 UBA3 UBE2K UBE2M UBL7 UBQLN1 UBXN7 UCHL1 UCHL3 YAF2
Entrez ID		25764	4738
HPRD ID		13724	04412
Ensembl ID		ENSG00000242028	ENSG00000129559
Uniprot IDs		Q9NX55	Q15843
PDB IDs		6C95 6PW9 9F1D	1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2N7K 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP 4P5O 6R7F 6R7I 6TTU 7B5L 7B5N 7ONI 8B3G 8B3I 8CAF 8H38 8Q7H 8RX0 8WQC 8WQG 8WZN 8WZO
Enriched GO Terms of Interacting Partners?		Intermediate Filament NatA Complex N-terminal Protein Amino Acid Acetylation	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin Protein Ligase Binding Proteasomal Protein Catabolic Process Ubiquitin Binding Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Protein Modification Process Protein Modification By Small Protein Conjugation Cytosol Positive Regulation Of Catabolic Process Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Nucleoplasm Regulation Of Post-translational Protein Modification Regulation Of Proteolysis Protein Ubiquitination Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Deubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Nucleus Protein Polyubiquitination Protein Targeting To Vacuole Involved In Autophagy Cullin-RING Ubiquitin Ligase Complex DeNEDDylase Activity Aggresome ATP-dependent Protein Folding Chaperone Polyubiquitin Modification-dependent Protein Binding Regulation Of Proteasomal Protein Catabolic Process Protein Folding Response To Stress Protein Neddylation Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Stability Positive Regulation Of Metabolic Process Cellular Response To Stress Cytoplasm
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