HYPK and PHC3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HYPK	PHC3
Description		huntingtin interacting protein K	polyhomeotic homolog 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton Protein-containing Complex	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	Protein Binding Protein Folding Chaperone	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Metal Ion Binding
	Biological Process	Protein Folding Negative Regulation Of Apoptotic Process Protein Stabilization	Negative Regulation Of DNA-templated Transcription
Pathways			Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823)
Interacting Genes		31 interacting genes: BOLL C2orf68 CSNK2B CYSRT1 HNRNPF HTT KRTAP12-2 KRTAP19-5 KRTAP3-2 KRTAP3-3 KRTAP8-1 MAGEA1 MAP1LC3B MDFI NAA10 NAA15 NEDD8 PCBP1 PHC3 PRR20A PRR20B PRR20C PRR20D PRR20E RBFOX1 RHOXF2 SP4 TENT5A THAP1 TXLNA VENTX	4 interacting genes: AGR2 H3-4 HYPK OGT
Entrez ID		25764	80012
HPRD ID		13724	10149
Ensembl ID		ENSG00000242028	ENSG00000173889
Uniprot IDs		Q9NX55	B4E2T1 E7EX82 Q8NDX5
PDB IDs		6C95 6PW9 9F1D	4PZN 4PZO
Enriched GO Terms of Interacting Partners?		Intermediate Filament NatA Complex N-terminal Protein Amino Acid Acetylation	DNA Replication-dependent Chromatin Assembly Spermatogonial Cell Division Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex Non-canonical Inflammasome Complex Assembly Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Protein Localization To Membrane Protein O-acetylglucosaminyltransferase Activity Lung Goblet Cell Differentiation Positive Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of Transcription By Glucose NSL Complex Dystroglycan Binding Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
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