C10orf67 and ALOX5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		C10orf67	ALOX5
Description		chromosome 10 open reading frame 67	arachidonate 5-lipoxygenase
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Extracellular Region Extracellular Space Nucleus Nuclear Envelope Nuclear Envelope Lumen Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Matrix Nuclear Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding	Arachidonate 5-lipoxygenase Activity Arachidonate 12(S)-lipoxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hydrolase Activity Arachidonate 8(S)-lipoxygenase Activity Metal Ion Binding Dioxygenase Activity
	Biological Process		Long-chain Fatty Acid Metabolic Process Negative Regulation Of Endothelial Cell Proliferation Leukocyte Chemotaxis Involved In Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Leukotriene Production Involved In Inflammatory Response Lipid Metabolic Process Icosanoid Metabolic Process Leukotriene Metabolic Process Response To Stress Inflammatory Response Humoral Immune Response Negative Regulation Of Angiogenesis Arachidonate Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Positive Regulation Of Bone Mineralization Lipid Oxidation Dendritic Cell Migration Glucose Homeostasis Long-chain Fatty Acid Biosynthetic Process Regulation Of Fat Cell Differentiation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Regulation Of Insulin Secretion Negative Regulation Of Vascular Wound Healing Negative Regulation Of Wound Healing Regulation Of Inflammatory Response To Wounding Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cellular Response To Oxidative Stress Leukotriene A4 Biosynthetic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Lipoxin Biosynthetic Process
Pathways			Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Biosynthesis of Lipoxins (LX) Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Interleukin-18 signaling Biosynthesis of D-series resolvins Biosynthesis of maresins Biosynthesis of E-series 18(S)-resolvins Biosynthesis of aspirin-triggered D-series resolvins Biosynthesis of E-series 18(R)-resolvins Biosynthesis of DPAn-3-derived protectins and resolvins Biosynthesis of DPAn-3-derived maresins Biosynthesis of DPAn-3-derived 13-series resolvins Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
Drugs			Icosapent Vitamin E Masoprocol Aminosalicylic acid Mesalazine Montelukast Diethylcarbamazine Zileuton Sulfasalazine Meclofenamic acid Balsalazide Minocycline Hyperforin Resveratrol Licofelone MLN-977 Morniflumate Diacerein Fostamatinib Rhein alpha-Tocopherol succinate D-alpha-Tocopherol acetate
Diseases
GWAS		Crohn's disease and sarcoidosis (combined) ( 18723019) Heel bone mineral density ( 30598549) Systemic lupus erythematosus ( 19838195)	Alanine aminotransferase levels ( 33547301) Cholesterol, total ( 24097068) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 20139978 32888494) Mean corpuscular volume ( 20139978) Total cholesterol levels ( 28334899)
Interacting Genes		13 interacting genes: ACSF2 ALOX5 BCL2L1 BCL2L2 NOD2 ORMDL3 SEC22A SYT16 TMED8 TMEM14B TMEM19 TMEM208 TNF	27 interacting genes: ACTB ALOX5AP ALPL APP C10orf67 CCDC174 CEP57L1 CEP63 COTL1 DICER1 GATC GRB2 HHIPL2 HSD17B1 LCN1 LTC4S MAD1L1 MAPKAPK2 MEOX1 MEOX2 MTDH NUTM1 OOEP REL SYCE1 TBC1D7 TGFBRAP1
Entrez ID		256815	240
HPRD ID		12585	01065
Ensembl ID		ENSG00000179133	ENSG00000012779
Uniprot IDs		A0A6E2AE84 Q8IYJ2	P09917
PDB IDs			3O8Y 3V92 3V98 3V99 6N2W 6NCF 7TTJ 7TTK 7TTL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Negative Regulation Of Vascular Wound Healing Negative Regulation Of Leukocyte Apoptotic Process Bcl-2 Family Protein Complex Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Vascular Wound Healing Extrinsic Apoptotic Signaling Pathway Regulation Of Membrane Lipid Metabolic Process Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Release Of Cytochrome C From Mitochondria Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Epithelial Cell Proliferation Mitochondrial Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Apoptotic Process Channel Activity Negative Regulation Of Programmed Cell Death Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Process In Bone Marrow Cell Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding Negative Regulation Of Endothelial Cell Proliferation Leukotriene A4 Metabolic Process Leukotriene Production Involved In Inflammatory Response Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Wound Healing Arachidonate 8(S)-lipoxygenase Activity Apoptotic Mitochondrial Changes Cellular Response To Ionizing Radiation Positive Regulation Of Interleukin-1 Production Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of L-glutamate Import Across Plasma Membrane Positive Regulation Of Interleukin-8 Production Positive Regulation Of Fractalkine Production Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Leukotriene Metabolic Process Leukotriene-C4 Synthase Activity Somite Specification Embryonic Pattern Specification
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