C10orf67 and TMED8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		C10orf67	TMED8
Description		chromosome 10 open reading frame 67	transmembrane p24 trafficking protein family member 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion
	Molecular Function	Protein Binding	Protein Binding
	Biological Process
Pathways
Drugs
Diseases
GWAS		Crohn's disease and sarcoidosis (combined) ( 18723019) Heel bone mineral density ( 30598549) Systemic lupus erythematosus ( 19838195)
Interacting Genes		13 interacting genes: ACSF2 ALOX5 BCL2L1 BCL2L2 NOD2 ORMDL3 SEC22A SYT16 TMED8 TMEM14B TMEM19 TMEM208 TNF	32 interacting genes: ADTRP AMIGO2 APOL2 ARL6IP1 C10orf67 CIAO2A CMTM5 CMTM6 CYB561D1 DEFB129 DERL1 DGAT2L6 EI24 H4C7 LAPTM4A MDK MMGT1 MRPL41 MRPS18B MTIF3 NDUFA12 REEP6 SERP2 STX8 SUSD3 TMEM115 TMEM121 TMEM218 TMEM254 TRAM1L1 UNC50 ZDHHC16
Entrez ID		256815	283578
HPRD ID		12585	18201
Ensembl ID		ENSG00000179133	ENSG00000100580
Uniprot IDs		A0A6E2AE84 Q8IYJ2	Q6PL24
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Negative Regulation Of Vascular Wound Healing Negative Regulation Of Leukocyte Apoptotic Process Bcl-2 Family Protein Complex Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Vascular Wound Healing Extrinsic Apoptotic Signaling Pathway Regulation Of Membrane Lipid Metabolic Process Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Release Of Cytochrome C From Mitochondria Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Epithelial Cell Proliferation Mitochondrial Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Apoptotic Process Channel Activity Negative Regulation Of Programmed Cell Death Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Process In Bone Marrow Cell Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding Negative Regulation Of Endothelial Cell Proliferation Leukotriene A4 Metabolic Process Leukotriene Production Involved In Inflammatory Response Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Wound Healing Arachidonate 8(S)-lipoxygenase Activity Apoptotic Mitochondrial Changes Cellular Response To Ionizing Radiation Positive Regulation Of Interleukin-1 Production Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of L-glutamate Import Across Plasma Membrane Positive Regulation Of Interleukin-8 Production Positive Regulation Of Fractalkine Production Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Endoplasmic Reticulum Membrane
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