PCSK9 and LDLR

Number of citations of the paper that reports this interaction (PMID 17435765)
55

Data Source:
HPRD (in vitro)

		PCSK9	LDLR
Gene Name		proprotein convertase subtilisin/kexin type 9	low density lipoprotein receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Lysosome Early Endosome Late Endosome Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Extrinsic Component Of External Side Of Plasma Membrane Perinuclear Region Of Cytoplasm	Lysosome Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Coated Pit External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Low-density Lipoprotein Particle Receptor Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Sodium Channel Inhibitor Activity Low-density Lipoprotein Particle Binding Apolipoprotein Binding Very-low-density Lipoprotein Particle Binding Apolipoprotein Receptor Binding Protein Self-association Poly(A) RNA Binding Low-density Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding	Glycoprotein Binding Low-density Lipoprotein Receptor Activity Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Very-low-density Lipoprotein Particle Receptor Activity Clathrin Heavy Chain Binding
	Biological Process	Kidney Development Liver Development Negative Regulation Of Receptor Recycling Positive Regulation Of Receptor Internalization Proteolysis Triglyceride Metabolic Process Phospholipid Metabolic Process Apoptotic Process Lysosomal Transport Cholesterol Metabolic Process Cellular Response To Starvation Regulation Of Receptor Activity Negative Regulation Of Low-density Lipoprotein Particle Clearance Protein Autoprocessing Neurogenesis Neuron Differentiation Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cellular Response To Insulin Stimulus Lipoprotein Metabolic Process Cholesterol Homeostasis Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process	Retinoid Metabolic Process Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phototransduction, Visible Light Cholesterol Metabolic Process Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Phosphatidylcholine Catabolic Process Phospholipid Transport Viral Process Intestinal Cholesterol Absorption Cholesterol Transport Low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Small Molecule Metabolic Process Cholesterol Import Regulation Of Cholesterol Homeostasis
Pathways			Lipoprotein metabolism LDL-mediated lipid transport Visual phototransduction Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Lipid digestion, mobilization, and transport Diseases associated with visual transduction Retinoid metabolism and transport
Drugs			Porfimer Alpha-D-Mannose
Diseases
GWAS		Cholesterol, total ( 20686565) Coronary heart disease ( 21378990) LDL cholesterol ( 23726366 18193043 18193044 20864672 19060906 20686565) Lipid metabolism phenotypes ( 22286219) Metabolite levels ( 22916037) Myocardial infarction (early onset) ( 19198609) Response to statin therapy (LDL-C) ( 22331829)	Cardiovascular disease risk factors ( 21943158) Carotid intima media thickness ( 21909108) Cholesterol, total ( 19060911 20686565) Coronary heart disease ( 21378990) LDL cholesterol ( 23726366 18193043 18193044 20864672 19060906 19060910 19060911 20686565) Lipid metabolism phenotypes ( 22286219 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152) Metabolite levels ( 21909109 22916037) Myocardial infarction (early onset) ( 19198609)
Protein-Protein Interactions		3 interactors: BACE1 BIRC2 LDLR	15 interactors: AP1M2 APOB APOE CD36 CREBBP DAB1 DAB2 HSPA5 LDLRAP1 LRPAP1 MAP4 MYLIP PCSK9 PF4 SNX17
Entrez ID		255738	3949
HPRD ID		07080	06091
Ensembl ID		ENSG00000169174	ENSG00000130164
Uniprot IDs		Q8NBP7	P01130
PDB IDs		2P4E 2PMW 2QTW 2W2M 2W2N 2W2O 2W2P 2W2Q 2XTJ 3BPS 3GCW 3GCX 3H42 3M0C 3P5B 3P5C 3SQO 4K8R	1AJJ 1D2J 1F5Y 1F8Z 1HJ7 1HZ8 1I0U 1IJQ 1LDL 1LDR 1LRX 1N7D 1XFE 2FCW 2KRI 2LGP 2M7P 2W2M 2W2N 2W2O 2W2P 2W2Q 3BPS 3GCW 3GCX 3M0C 3P5B 3P5C 3SO6
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Cholesterol Import Regulation Of Phosphatidylcholine Catabolic Process Regulation Of Protein Monoubiquitination Regulation Of Protein K63-linked Ubiquitination Intestinal Cholesterol Absorption Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Necroptotic Process Lipid Digestion Negative Regulation Of Necrotic Cell Death Regulation Of RIG-I Signaling Pathway Regulation Of Necroptotic Process Positive Regulation Of Triglyceride Biosynthetic Process Protein Catabolic Process Lipoprotein Catabolic Process Regulation Of Cholesterol Homeostasis Regulation Of Triglyceride Biosynthetic Process Membrane Protein Ectodomain Proteolysis Regulation Of Necrotic Cell Death Beta-amyloid Metabolic Process Intestinal Absorption Low-density Lipoprotein Particle Clearance Necroptotic Process Membrane Protein Proteolysis Regulation Of Triglyceride Metabolic Process Plasma Lipoprotein Particle Clearance Regulation Of Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Programmed Necrotic Cell Death Necrotic Cell Death Response To Abiotic Stimulus Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Plasma Lipoprotein Particle Levels Cellular Component Disassembly Involved In Execution Phase Of Apoptosis TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Sterol Transport Cholesterol Transport Execution Phase Of Apoptosis Phototransduction, Visible Light Cholesterol Homeostasis Retinoid Metabolic Process Sterol Homeostasis Toll-like Receptor 4 Signaling Pathway	Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Receptor-mediated Endocytosis Cholesterol Homeostasis Sterol Homeostasis Vesicle-mediated Transport Plasma Lipoprotein Particle Clearance Lipid Homeostasis Cholesterol Metabolic Process Sterol Metabolic Process Regulation Of Plasma Lipoprotein Particle Levels Cholesterol Transport Sterol Transport Endocytosis Regulation Of Endocytosis Low-density Lipoprotein Particle Clearance Cellular Localization Steroid Metabolic Process Positive Regulation Of Endocytosis Cerebellum Structural Organization Positive Regulation Of Macrophage Derived Foam Cell Differentiation Establishment Of Localization In Cell Regulation Of Signal Transduction Regulation Of Cholesterol Metabolic Process Positive Regulation Of Receptor-mediated Endocytosis Alcohol Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Signaling Regulation Of Vesicle-mediated Transport Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Lipid Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of Beta-amyloid Clearance Positive Regulation Of Cell Differentiation Platelet Degranulation Regulation Of Low-density Lipoprotein Particle Clearance CGMP-mediated Signaling Cholesterol Catabolic Process Low-density Lipoprotein Particle Remodeling Transport Regulation Of Cell Differentiation Protein Catabolic Process Positive Regulation Of Cholesterol Storage Lipid Transport Triglyceride Metabolic Process Regulation Of Steroid Metabolic Process Negative Regulation Of Signal Transduction Lipoprotein Transport Lipid Localization Neutral Lipid Metabolic Process
Tagcloud ?		accelerated alcoholic apolipoprotein casein convertase disrupting exacerbated exacerbates golgi hepatoblastoma hepg2 inflammation injections kexin knockout ko ldlr livers mtorc1 nafld p70 posttranscriptional proprotein s6 scap srebp sterol subcutaneous subtilisin	atresia atretic chicken cloning clusterin correlating follicle follicles granulosa heterodimer hitherto internalize intracellularly intriguing lr8 megalin migrates oocyte oocytes polyacrylamide postovulatory prime sac situations successors thereof uncovered vitellogenesis yolk
Tagcloud (Difference) ?		accelerated alcoholic apolipoprotein casein convertase disrupting exacerbated exacerbates golgi hepatoblastoma hepg2 inflammation injections kexin knockout ko livers mtorc1 nafld p70 posttranscriptional proprotein s6 scap srebp sterol subcutaneous subtilisin	atresia atretic chicken cloning clusterin correlating follicle follicles granulosa heterodimer hitherto internalize intracellularly intriguing lr8 megalin migrates oocyte oocytes polyacrylamide postovulatory prime sac situations successors thereof uncovered vitellogenesis yolk
Tagcloud (Intersection) ?		ldlr