PCSK9 and BIRC2

Number of citations of the paper that reports this interaction (PMID 23085658)
2

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study)

		PCSK9	BIRC2
Gene Name		proprotein convertase subtilisin/kexin type 9	baculoviral IAP repeat containing 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Lysosome Early Endosome Late Endosome Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Extrinsic Component Of External Side Of Plasma Membrane Perinuclear Region Of Cytoplasm	XY Body Nucleus Cytoplasm Cytosol Spindle Microtubule Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Membrane Raft
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Sodium Channel Inhibitor Activity Low-density Lipoprotein Particle Binding Apolipoprotein Binding Very-low-density Lipoprotein Particle Binding Apolipoprotein Receptor Binding Protein Self-association Poly(A) RNA Binding Low-density Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein N-terminus Binding
	Biological Process	Kidney Development Liver Development Negative Regulation Of Receptor Recycling Positive Regulation Of Receptor Internalization Proteolysis Triglyceride Metabolic Process Phospholipid Metabolic Process Apoptotic Process Lysosomal Transport Cholesterol Metabolic Process Cellular Response To Starvation Regulation Of Receptor Activity Negative Regulation Of Low-density Lipoprotein Particle Clearance Protein Autoprocessing Neurogenesis Neuron Differentiation Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cellular Response To Insulin Stimulus Lipoprotein Metabolic Process Cholesterol Homeostasis Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process	Protein Polyubiquitination Response To Hypoxia Placenta Development Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Surface Receptor Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Regulation Of RIG-I Signaling Pathway Regulation Of Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Innate Immune Response Response To Ethanol Regulation Of Cell Differentiation Regulation Of Inflammatory Response Protein Heterooligomerization Response To CAMP Regulation Of Cell Cycle Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Necroptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Mitotic Spindle Assembly Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Apoptotic cleavage of cellular proteins IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling Apoptotic execution phase MyD88-independent cascade Activated TLR4 signalling Toll-Like Receptors Cascades Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Programmed Cell Death Innate Immune System
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) Coronary heart disease ( 21378990) LDL cholesterol ( 23726366 18193043 18193044 20864672 19060906 20686565) Lipid metabolism phenotypes ( 22286219) Metabolite levels ( 22916037) Myocardial infarction (early onset) ( 19198609) Response to statin therapy (LDL-C) ( 22331829)	Prostate cancer ( 23535732)
Protein-Protein Interactions		3 interactors: BACE1 BIRC2 LDLR	58 interactors: BIRC5 BIRC7 BOLA1 CASP2 CASP3 CASP7 CASP9 CBLC CD40 DIABLO DZIP3 EAF2 EXOSC5 FBXO7 GAS1 GCC1 GFAP GSPT1 HSP90B1 HTRA2 IKBKE IKBKG JUP LTBR MAGEA11 MAP3K2 MAP3K3 NMB OTUB1 PACS2 PCSK9 PPM1K RAC1 RAF1 RHOA RIPK1 RIPK2 RIPK3 RIPK4 RNF181 TRADD TRAF1 TRAF2 TRIM34 TSG101 TSGA10 UBB UBC UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2J1 UBE2Q2 UBE2S UBE2V1 UBE2W WDYHV1
Entrez ID		255738	329
HPRD ID		07080	03419
Ensembl ID		ENSG00000169174	ENSG00000110330
Uniprot IDs		Q8NBP7	Q13490
PDB IDs		2P4E 2PMW 2QTW 2W2M 2W2N 2W2O 2W2P 2W2Q 2XTJ 3BPS 3GCW 3GCX 3H42 3M0C 3P5B 3P5C 3SQO 4K8R	1QBH 2L9M 3D9T 3D9U 3M1D 3MUP 3OZ1 3T6P 3UW4 4EB9 4HY4 4HY5 4LGE 4LGU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Cholesterol Import Regulation Of Phosphatidylcholine Catabolic Process Regulation Of Protein Monoubiquitination Regulation Of Protein K63-linked Ubiquitination Intestinal Cholesterol Absorption Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Necroptotic Process Lipid Digestion Negative Regulation Of Necrotic Cell Death Regulation Of RIG-I Signaling Pathway Regulation Of Necroptotic Process Positive Regulation Of Triglyceride Biosynthetic Process Protein Catabolic Process Lipoprotein Catabolic Process Regulation Of Cholesterol Homeostasis Regulation Of Triglyceride Biosynthetic Process Membrane Protein Ectodomain Proteolysis Regulation Of Necrotic Cell Death Beta-amyloid Metabolic Process Intestinal Absorption Low-density Lipoprotein Particle Clearance Necroptotic Process Membrane Protein Proteolysis Regulation Of Triglyceride Metabolic Process Plasma Lipoprotein Particle Clearance Regulation Of Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Programmed Necrotic Cell Death Necrotic Cell Death Response To Abiotic Stimulus Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Plasma Lipoprotein Particle Levels Cellular Component Disassembly Involved In Execution Phase Of Apoptosis TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Sterol Transport Cholesterol Transport Execution Phase Of Apoptosis Phototransduction, Visible Light Cholesterol Homeostasis Retinoid Metabolic Process Sterol Homeostasis Toll-like Receptor 4 Signaling Pathway	Programmed Cell Death Cell Death Death Apoptotic Process Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Activation Of Innate Immune Response Regulation Of Protein Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Innate Immune Response Protein Ubiquitination Cellular Response To Stress Regulation Of Cell Death Protein Modification By Small Protein Conjugation Positive Regulation Of Cellular Protein Metabolic Process Protein Polyubiquitination Protein Processing Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Signal Transduction Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cell Death Protein Catabolic Process Cellular Macromolecule Catabolic Process Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Transferase Activity Response To Stress Cellular Protein Catabolic Process Cellular Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Cellular Protein Metabolic Process
Tagcloud ?		accelerated alcoholic apolipoprotein casein convertase disrupting exacerbated exacerbates golgi hepatoblastoma hepg2 inflammation injections kexin knockout ko ldlr livers mtorc1 nafld p70 posttranscriptional proprotein s6 scap srebp sterol subcutaneous subtilisin	2b arrest baculoviral c4 caspases cdk2 ciap1 consumer deacetylases dependently du ester hdacs immortalized lncap maa malformation methoxyacetic named p63 p73 pharmaceutical phthalates prns prostatic rwpe spermatocyte suppresses turning
Tagcloud (Difference) ?		accelerated alcoholic apolipoprotein casein convertase disrupting exacerbated exacerbates golgi hepatoblastoma hepg2 inflammation injections kexin knockout ko ldlr livers mtorc1 nafld p70 posttranscriptional proprotein s6 scap srebp sterol subcutaneous subtilisin	2b arrest baculoviral c4 caspases cdk2 ciap1 consumer deacetylases dependently du ester hdacs immortalized lncap maa malformation methoxyacetic named p63 p73 pharmaceutical phthalates prns prostatic rwpe spermatocyte suppresses turning
Tagcloud (Intersection) ?