PCSK9

Gene Name		proprotein convertase subtilisin/kexin type 9
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Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Lysosome Early Endosome Late Endosome Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Extrinsic Component Of External Side Of Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Sodium Channel Inhibitor Activity Low-density Lipoprotein Particle Binding Apolipoprotein Binding Very-low-density Lipoprotein Particle Binding Apolipoprotein Receptor Binding Protein Self-association Poly(A) RNA Binding Low-density Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding
	Biological Process	Kidney Development Liver Development Negative Regulation Of Receptor Recycling Positive Regulation Of Receptor Internalization Proteolysis Triglyceride Metabolic Process Phospholipid Metabolic Process Apoptotic Process Lysosomal Transport Cholesterol Metabolic Process Cellular Response To Starvation Regulation Of Receptor Activity Negative Regulation Of Low-density Lipoprotein Particle Clearance Protein Autoprocessing Neurogenesis Neuron Differentiation Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cellular Response To Insulin Stimulus Lipoprotein Metabolic Process Cholesterol Homeostasis Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process
Pathways
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) Coronary heart disease ( 21378990) LDL cholesterol ( 23726366 18193043 18193044 20864672 19060906 20686565) Lipid metabolism phenotypes ( 22286219) Metabolite levels ( 22916037) Myocardial infarction (early onset) ( 19198609) Response to statin therapy (LDL-C) ( 22331829)
Protein-protein Interactions		3 interactors: BACE1 BIRC2 LDLR
Entrez ID		255738
HPRD ID		07080
Ensembl ID		ENSG00000169174
Uniprot IDs		Q8NBP7
PDB IDs		2P4E 2PMW 2QTW 2W2M 2W2N 2W2O 2W2P 2W2Q 2XTJ 3BPS 3GCW 3GCX 3H42 3M0C 3P5B 3P5C 3SQO 4K8R
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Cholesterol Import Regulation Of Phosphatidylcholine Catabolic Process Regulation Of Protein Monoubiquitination Regulation Of Protein K63-linked Ubiquitination Intestinal Cholesterol Absorption Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Necroptotic Process Lipid Digestion Negative Regulation Of Necrotic Cell Death Regulation Of RIG-I Signaling Pathway Regulation Of Necroptotic Process Positive Regulation Of Triglyceride Biosynthetic Process Protein Catabolic Process Lipoprotein Catabolic Process Regulation Of Cholesterol Homeostasis Regulation Of Triglyceride Biosynthetic Process Membrane Protein Ectodomain Proteolysis Regulation Of Necrotic Cell Death Beta-amyloid Metabolic Process Intestinal Absorption Low-density Lipoprotein Particle Clearance Necroptotic Process Membrane Protein Proteolysis Regulation Of Triglyceride Metabolic Process Plasma Lipoprotein Particle Clearance Regulation Of Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Programmed Necrotic Cell Death Necrotic Cell Death Response To Abiotic Stimulus Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Plasma Lipoprotein Particle Levels Cellular Component Disassembly Involved In Execution Phase Of Apoptosis TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Sterol Transport Cholesterol Transport Execution Phase Of Apoptosis Phototransduction, Visible Light Cholesterol Homeostasis Retinoid Metabolic Process Sterol Homeostasis Toll-like Receptor 4 Signaling Pathway
Tagcloud ?		accelerated alcoholic apolipoprotein casein convertase disrupting exacerbated exacerbates golgi hepatoblastoma hepg2 inflammation injections kexin knockout ko ldlr livers mtorc1 nafld p70 posttranscriptional proprotein s6 scap srebp sterol subcutaneous subtilisin