GABPB1 and HCFC1

Number of citations of the paper that reports this interaction (PubMedID 10675337)
54

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		GABPB1	HCFC1
Description		GA binding protein transcription factor subunit beta 1	host cell factor C1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasmic Ribonucleoprotein Granule	Histone Acetyltransferase Complex Nucleus Nucleoplasm Cytoplasm Membrane Protein-containing Complex Histone Methyltransferase Complex Neuronal Cell Body NSL Complex MLL1/2 Complex Set1C/COMPASS Complex MLL1 Complex
	Molecular Function	Transcription Cis-regulatory Region Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Protein-macromolecule Adaptor Activity Chromatin DNA Binding Identical Protein Binding Cadherin Binding DNA-binding Transcription Factor Binding
	Biological Process	Mitochondrion Organization Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Hatching Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Positive Regulation Of Gene Expression Release From Viral Latency Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization
Pathways			Transcriptional activation of mitochondrial biogenesis HATs acetylate histones UCH proteinases Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases
GWAS		Superior frontal gyrus volume ( 31530798)	Celiac disease ( 22057235) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus ( 26502338)
Interacting Genes		30 interacting genes: ADGRB2 ATF1 BAIAP2L2 CEBPA CIC EP300 FAM90A1 FANCG GABPA HCFC1 IL16 LMO1 LMO3 LMO4 MAGEB18 MED20 POGZ RBM11 RSPH14 RYBP SNRPA SNRPB2 SNW1 TDRD7 TRAF2 TRIM55 TRIM63 USO1 YAF2 ZDHHC17	34 interacting genes: ASF1B CEBPA CLP1 CREB3 CREBZF E2F1 E2F3 E2F4 EGR2 FOXK2 GABPA GABPB1 HCFC1R1 HSPA1A JUN KMT2A MED25 NFE2L1 OGT PDCD2 POU2F1 PPARGC1A PPARGC1B PPP1CC PSIP1 SETD7 SIAH1 SIN3A SP1 SUMO2 TAF9 THAP11 THAP7 ZBTB17
Entrez ID		2553	3054
HPRD ID		15975	02061
Ensembl ID		ENSG00000104064	ENSG00000172534
Uniprot IDs		Q06547	A6NEM2 P51610
PDB IDs			4GO6 4N39 4N3A 4N3B 4N3C 5LWV 6MA1 6MA2 6MA3 6MA4 6MA5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Transcription Coactivator Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Transcription Coregulator Activity Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Spliceosomal SnRNP Complex Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression U1 SnRNA Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus STAT Family Protein Binding TORC2 Signaling Positive Regulation Of Metabolic Process Host-mediated Activation Of Viral Transcription Chromatin DNA Binding U1 SnRNP Transcription Corepressor Activity Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Intracellular Signaling Cassette Histone Acetyltransferase Complex Transcription Regulator Complex Regulation Of Protein-containing Complex Assembly Nuclear Speck Nuclear Androgen Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Host-mediated Perturbation Of Viral Transcription RNA Polymerase II Transcription Regulator Complex Chromatin Binding Negative Regulation Of Biosynthetic Process	Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Chromatin Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Transcription Regulator Complex Integrated Stress Response Signaling Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Population Proliferation DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Programmed Cell Death Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Population Proliferation Circadian Regulation Of Gene Expression
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