GABPB1 and MED20

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GABPB1	MED20
Description		GA binding protein transcription factor subunit beta 1	mediator complex subunit 20
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasmic Ribonucleoprotein Granule	Nucleus Nucleoplasm Mediator Complex Protein-containing Complex Core Mediator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding Protein Binding	Transcription Coregulator Activity Transcription Coactivator Activity DNA-directed RNA Polymerase Activity Protein Binding
	Biological Process	Mitochondrion Organization Positive Regulation Of Transcription By RNA Polymerase II	DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Skeletal Muscle Cell Differentiation RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways			PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Superior frontal gyrus volume ( 31530798)	Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin ( 20139978 27863252) Mean corpuscular volume ( 20139978 23263863 27863252) Metabolite levels ( 23823483) Red blood cell count ( 20139978)
Interacting Genes		30 interacting genes: ADGRB2 ATF1 BAIAP2L2 CEBPA CIC EP300 FAM90A1 FANCG GABPA HCFC1 IL16 LMO1 LMO3 LMO4 MAGEB18 MED20 POGZ RBM11 RSPH14 RYBP SNRPA SNRPB2 SNW1 TDRD7 TRAF2 TRIM55 TRIM63 USO1 YAF2 ZDHHC17	18 interacting genes: ANKS1A CD300C CEBPB CYB5R2 ERP27 ESR1 ESR2 GABPB1 MARK4 MED18 MED29 MED8 PIH1D2 POLR1B PSORS1C2 TRIM69 UBC YY1
Entrez ID		2553	9477
HPRD ID		15975	15638
Ensembl ID		ENSG00000104064	ENSG00000124641
Uniprot IDs		Q06547	B3KUJ9 Q9H944
PDB IDs			7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Transcription Coactivator Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Transcription Coregulator Activity Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Spliceosomal SnRNP Complex Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression U1 SnRNA Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus STAT Family Protein Binding TORC2 Signaling Positive Regulation Of Metabolic Process Host-mediated Activation Of Viral Transcription Chromatin DNA Binding U1 SnRNP Transcription Corepressor Activity Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Intracellular Signaling Cassette Histone Acetyltransferase Complex Transcription Regulator Complex Regulation Of Protein-containing Complex Assembly Nuclear Speck Nuclear Androgen Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Host-mediated Perturbation Of Viral Transcription RNA Polymerase II Transcription Regulator Complex Chromatin Binding Negative Regulation Of Biosynthetic Process	RNA Polymerase II Preinitiation Complex Assembly Transcription Preinitiation Complex Assembly Core Mediator Complex Nuclear Estrogen Receptor Activity Mediator Complex Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Protein-DNA Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Estrogen Response Element Binding Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Mammary Gland Epithelial Cell Proliferation Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of DNA-templated Transcription Elongation Positive Regulation Of RNA Metabolic Process Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Transcription Coregulator Activity Negative Regulation Of MiRNA Transcription Steroid Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Cellular Response To Estradiol Stimulus Sequence-specific DNA Binding Cellular Response To Interleukin-1 Protein-containing Complex Assembly Nuclear Receptor Activity Regulation Of Transcription By RNA Polymerase II Granuloma Formation C/EBP Complex Immunoglobulin Heavy Chain V-D-J Recombination Nucleologenesis T-helper 1 Cell Activation Transcription Cis-regulatory Region Binding CHOP-C/EBP Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Sodium-dependent Phosphate Transport Positive Regulation Of Macromolecule Biosynthetic Process Prostate Epithelial Cord Elongation Regulation Of MiRNA Transcription Positive Regulation Of Nitric-oxide Synthase Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Protein-containing Complex Organization Response To Prostaglandin F
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