NAALADL2 and GRM2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		NAALADL2	GRM2
Gene Name		N-acetylated alpha-linked acidic dipeptidase-like 2	glutamate receptor, metabotropic 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane	Intracellular Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Axon Dendrite Presynaptic Membrane
	Molecular Function		Group II Metabotropic Glutamate Receptor Activity G-protein Coupled Receptor Activity Calcium Channel Regulator Activity Glutamate Receptor Activity
	Biological Process		Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Glutamate Secretion Regulation Of Synaptic Transmission, Glutamatergic
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs			Acamprosate
Diseases
GWAS		Height ( 23456168) Kawasaki disease ( 19132087) Metabolite levels (MHPG) ( 23319000) Sleep duration ( 23728906) Systemic lupus erythematosus ( 21408207)
Protein-Protein Interactions		6 interactors: APP GPR25 GRM2 ITM2B LAPTM4B SLC30A3	6 interactors: GNA15 GNAQ GRASP NAALADL2 RGS12 UBQLN1
Entrez ID		254827	2912
HPRD ID		16388	04977
Ensembl ID		ENSG00000177694	ENSG00000164082
Uniprot IDs		Q58DX5	Q14416 Q86YG3
PDB IDs
Enriched GO Terms of Interacting Partners?		Glutamate Receptor Signaling Pathway	Phospholipase C-activating Dopamine Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Platelet Activation Positive Regulation Of Hydrolase Activity Cellular Response To Stimulus Neuron Remodeling Positive Regulation Of Catalytic Activity Regulation Of Melanocyte Differentiation G-protein Coupled Acetylcholine Receptor Signaling Pathway Blood Coagulation Hemostasis Maternal Behavior Regulation Of Catenin Import Into Nucleus Regulation Of Developmental Pigmentation Response To Stimulus Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Neuron Maturation Cell Activation Forebrain Neuron Development Response To Wounding Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Signal Transduction Regulation Of GTPase Activity Regulation Of Cellular Response To Oxidative Stress Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Signaling Forebrain Neuron Differentiation Glutamate Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Cell Communication Developmental Pigmentation Termination Of Signal Transduction
Tagcloud ?			asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi
Tagcloud (Difference) ?			asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi
Tagcloud (Intersection) ?