NAALADL2 and SLC30A3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		NAALADL2	SLC30A3
Description		N-acetylated alpha-linked acidic dipeptidase like 2	solute carrier family 30 member 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Membrane	Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Neuron Projection Synapse Hippocampal Mossy Fiber Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Microvesicle
	Molecular Function	Protein Binding	Zinc Ion Transmembrane Transporter Activity Protein Binding Monoatomic Cation Transmembrane Transporter Activity Antiporter Activity Metal Ion Binding
	Biological Process	Response To Bacterium	Monoatomic Ion Transport Monoatomic Cation Transport Zinc Ion Transport Response To Zinc Ion Positive Regulation Of Transport Transmembrane Transport Zinc Ion Import Into Organelle Zinc Ion Transmembrane Transport Zinc Ion Import Into Synaptic Vesicle Zinc Ion Import Into Lysosome
Pathways			Zinc efflux and compartmentalization by the SLC30 family
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Autism spectrum disorder ( 26398136) Beta blocker survival benefit in heart failure with reduced ejection fraction (time to all cause mortality x beta blocker interaction) ( 33012170) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Familial lung adenocarcinoma ( 29924316) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 23456168) Idiopathic downbeat nystagmus ( 32157568) Influenza A (H1N1) severity ( 26379185) Kawasaki disease ( 19132087) Loneliness ( 27629369) Metabolite levels (MHPG) ( 23319000) Mitochondrial DNA copy number ( 30704525) Number of sexual partners ( 30643258) Priapism in sickle cell disease ( 31668730) Prostate cancer aggressiveness ( 25939597) Rapid automised naming of pictures ( 30741946) Response to alcohol consumption (flushing response) ( 29460428) Sleep duration ( 23728906) Systemic lupus erythematosus ( 21408207) Triglyceride levels in HIV infection ( 33109212)	Metabolite levels ( 23823483)
Interacting Genes		6 interacting genes: APP GPR25 GRM2 ITM2B LAPTM4B SLC30A3	33 interacting genes: AP3B1 AP3D1 AP3S1 AQP6 CD40 CD79A CGRRF1 CYB5R3 DNAJC5 ELOVL4 FCRL3 FKBP7 GJA8 GOLM1 GPR152 GPR42 GPX8 HSD17B13 LMNA NAALADL2 RETREG3 RNF19B RTN3 SAR1A SCN3B SGPL1 SLC10A6 SLC18A1 SLC30A8 SLC34A2 SLC35H1 TMEM14B TMEM242
Entrez ID		254827	7781
HPRD ID		16388	11924
Ensembl ID		ENSG00000177694	ENSG00000115194
Uniprot IDs		Q58DX5	B4DXX8 Q99726
PDB IDs			8XN1
Enriched GO Terms of Interacting Partners?		Astrocyte Projection Endosome Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Amyloid-beta Complex Glutamate Receptor Signaling Pathway Growth Cone Lamellipodium Neuron Projection Plasma Membrane Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Zinc Ion Import Into Synaptic Vesicle Lysosome Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Group II Metabotropic Glutamate Receptor Activity Hippocampal Mossy Fiber Regulation Of Lysosomal Membrane Permeability Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Adult Behavior Cellular Response To Norepinephrine Stimulus G Protein-coupled Receptor Signaling Pathway Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Late Endosome Membrane Zinc Ion Import Into Lysosome Negative Regulation Of Lysosomal Protein Catabolic Process Multivesicular Body, Internal Vesicle Regulation Of Spontaneous Synaptic Transmission Regulation Of Synaptic Plasticity NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Intracellular Glutamate Homeostasis	Membrane Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Vesicle Cargo Loading AP-3 Adaptor Complex Anterograde Synaptic Vesicle Transport Melanosome Assembly Platelet Dense Granule Organization Membrane Coat Positive Regulation Of NK T Cell Differentiation Synaptic Vesicle Transport Synaptic Vesicle Coating Vesicle Coating Melanosome Organization Pigment Granule Organization Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Regulation Of NK T Cell Differentiation Anterograde Axonal Transport Endoplasmic Reticulum Vesicle Transport Along Microtubule Zinc Ion Import Into Organelle Vesicle Cytoskeletal Trafficking Transmembrane Transport Axon Cytoplasm Axonal Transport Secretory Granule Organization Protein Binding Synaptic Vesicle Recycling Axo-dendritic Transport Golgi To Vacuole Transport Organelle Transport Along Microtubule Endoplasmic Reticulum Membrane Endoplasmic Reticulum Tubular Network Organization Inorganic Cation Transmembrane Transport Presynapse Establishment Of Vesicle Localization Zinc Ion Transmembrane Transport Zinc Ion Transport Monoatomic Ion Transport Vesicle Localization Intracellular Zinc Ion Homeostasis Establishment Of Organelle Localization Nitrate Transmembrane Transporter Activity Inorganic Ion Transmembrane Transport Sphinganine-1-phosphate Aldolase Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport
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