NAALADL2

Description		N-acetylated alpha-linked acidic dipeptidase like 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Membrane
	Molecular Function	Protein Binding
	Biological Process	Response To Bacterium
Pathways
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Autism spectrum disorder ( 26398136) Beta blocker survival benefit in heart failure with reduced ejection fraction (time to all cause mortality x beta blocker interaction) ( 33012170) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Familial lung adenocarcinoma ( 29924316) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 23456168) Idiopathic downbeat nystagmus ( 32157568) Influenza A (H1N1) severity ( 26379185) Kawasaki disease ( 19132087) Loneliness ( 27629369) Metabolite levels (MHPG) ( 23319000) Mitochondrial DNA copy number ( 30704525) Number of sexual partners ( 30643258) Priapism in sickle cell disease ( 31668730) Prostate cancer aggressiveness ( 25939597) Rapid automised naming of pictures ( 30741946) Response to alcohol consumption (flushing response) ( 29460428) Sleep duration ( 23728906) Systemic lupus erythematosus ( 21408207) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		6 interacting genes: APP GPR25 GRM2 ITM2B LAPTM4B SLC30A3
Entrez ID		254827
HPRD ID		16388
Ensembl ID		ENSG00000177694
Uniprot IDs		Q58DX5
PDB IDs
Enriched GO Terms of Interacting Partners?		Astrocyte Projection Endosome Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Amyloid-beta Complex Glutamate Receptor Signaling Pathway Growth Cone Lamellipodium Neuron Projection Plasma Membrane Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Zinc Ion Import Into Synaptic Vesicle Lysosome Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Group II Metabotropic Glutamate Receptor Activity Hippocampal Mossy Fiber Regulation Of Lysosomal Membrane Permeability Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Adult Behavior Cellular Response To Norepinephrine Stimulus G Protein-coupled Receptor Signaling Pathway Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Late Endosome Membrane Zinc Ion Import Into Lysosome Negative Regulation Of Lysosomal Protein Catabolic Process Multivesicular Body, Internal Vesicle Regulation Of Spontaneous Synaptic Transmission Regulation Of Synaptic Plasticity NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Intracellular Glutamate Homeostasis
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