NAALADL2 and ITM2B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		NAALADL2	ITM2B
Description		N-acetylated alpha-linked acidic dipeptidase like 2	integral membrane protein 2B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Membrane	Golgi Membrane Extracellular Region Extracellular Space Endosome Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Golgi-associated Vesicle Membrane Organelle Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Amyloid-beta Binding Protein Binding ATP Binding
	Biological Process	Response To Bacterium	Nervous System Development Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process
Pathways			Amyloid fiber formation
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Autism spectrum disorder ( 26398136) Beta blocker survival benefit in heart failure with reduced ejection fraction (time to all cause mortality x beta blocker interaction) ( 33012170) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Familial lung adenocarcinoma ( 29924316) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 23456168) Idiopathic downbeat nystagmus ( 32157568) Influenza A (H1N1) severity ( 26379185) Kawasaki disease ( 19132087) Loneliness ( 27629369) Metabolite levels (MHPG) ( 23319000) Mitochondrial DNA copy number ( 30704525) Number of sexual partners ( 30643258) Priapism in sickle cell disease ( 31668730) Prostate cancer aggressiveness ( 25939597) Rapid automised naming of pictures ( 30741946) Response to alcohol consumption (flushing response) ( 29460428) Sleep duration ( 23728906) Systemic lupus erythematosus ( 21408207) Triglyceride levels in HIV infection ( 33109212)	Severe insulin-deficient type 2 diabetes ( 34737425)
Interacting Genes		6 interacting genes: APP GPR25 GRM2 ITM2B LAPTM4B SLC30A3	7 interacting genes: APP BCL2 CREB3 KASH5 LMNA NAALADL2 SYNE4
Entrez ID		254827	9445
HPRD ID		16388	04878
Ensembl ID		ENSG00000177694	ENSG00000136156
Uniprot IDs		Q58DX5	A0A384MDP7 Q9Y287
PDB IDs			8RNU
Enriched GO Terms of Interacting Partners?		Astrocyte Projection Endosome Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Amyloid-beta Complex Glutamate Receptor Signaling Pathway Growth Cone Lamellipodium Neuron Projection Plasma Membrane Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Zinc Ion Import Into Synaptic Vesicle Lysosome Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Group II Metabotropic Glutamate Receptor Activity Hippocampal Mossy Fiber Regulation Of Lysosomal Membrane Permeability Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Adult Behavior Cellular Response To Norepinephrine Stimulus G Protein-coupled Receptor Signaling Pathway Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Late Endosome Membrane Zinc Ion Import Into Lysosome Negative Regulation Of Lysosomal Protein Catabolic Process Multivesicular Body, Internal Vesicle Regulation Of Spontaneous Synaptic Transmission Regulation Of Synaptic Plasticity NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Intracellular Glutamate Homeostasis	Regulation Of Apoptotic Signaling Pathway Meiotic Nuclear Membrane Microtubule Tethering Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Neuron Maturation Regulation Of Calcium Ion Transport Positive Regulation Of Monocyte Chemotaxis Regulation Of Monocyte Chemotaxis Negative Regulation Of Apoptotic Signaling Pathway Nuclear Envelope Nuclear Outer Membrane Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Cell Migration Regulation Of Multicellular Organism Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Development Regulation Of Metal Ion Transport Regulation Of Cell Motility Identical Protein Binding Negative Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Cellular PH Reduction Striated Muscle Cell Development Positive Regulation Of Deacetylase Activity Regulation Of Monoatomic Ion Transport Regulation Of Locomotion Chromosome Localization Acetylcholine Receptor Activator Activity Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Leukocyte Chemotaxis Lipoprotein Particle Positive Regulation Of Protein Import Supramolecular Fiber Organization Muscle Cell Development CD8-positive, Alpha-beta T Cell Lineage Commitment BAD-BCL-2 Complex Channel Inhibitor Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Meiotic Spindle Pole PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production
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