FTL and KPNA3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		FTL	KPNA3
Description		ferritin light chain	karyopherin subunit alpha 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Autophagosome Cytosol Membrane Cytoplasmic Vesicle Azurophil Granule Lumen Autolysosome Extracellular Exosome Ferritin Complex	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol NLS-dependent Protein Nuclear Import Complex Host Cell
	Molecular Function	Iron Ion Binding Protein Binding Ferrous Iron Binding Ferric Iron Binding Identical Protein Binding Metal Ion Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Iron Ion Transport Intracellular Iron Ion Homeostasis	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Protein Transport Symbiont Entry Into Host Cell Protein-containing Complex Assembly Viral Penetration Into Host Nucleus
Pathways		Scavenging by Class A Receptors Golgi Associated Vesicle Biogenesis Neutrophil degranulation Iron uptake and transport	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs		Iron Dextran Protoporphyrin Ferric pyrophosphate Sodium ferric gluconate complex Ferric pyrophosphate citrate
Diseases		Neurodegeneration with brain iron accumulation (NBIA); Hallervorden-Spatz syndrome; Neuroferritinopathy; Aceruloplasminemia
GWAS			Inflammatory skin disease ( 25574825) Menopause (age at onset) ( 22267201) Obesity-related traits ( 23251661) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triiodothyronine/thyroxine ratio ( 30824882)
Interacting Genes		31 interacting genes: ACO1 CLEC4G FTH1 GADD45A GLP1R GRB2 HTT IGDCC3 KNG1 KPNA3 MAP3K12 MEOX2 MPHOSPH6 MTNR1B MYOC MYOG NTAQ1 PALS2 PIK3CA PPP1CC PTN RAP2A SDCBP SLC13A1 SMAD9 SPINK7 TAF10 UBC USHBP1 VKORC1 ZDHHC17	51 interacting genes: APOL6 ARNT ATM ATOSB BAHD1 CCDC102B CDKN1B COIL EPAS1 EPHA2 ERCC3 ESR2 FAM50B FTL GATA6 GRB10 GTF2H1 GTF2IRD1 HEXIM2 HIF1A HNRNPC HSPB1 KAT5 KPNB1 L3MBTL4 MAPK9 MAT2B MVP MYOD1 NFE2L2 NFKB1 NMNAT1 NRIP1 OGT POLR3C RAD52 RCC1 RPRD1A SLC5A11 SPMIP9 TGM2 TNIP3 TSSC4 UVSSA ZBTB24 ZCCHC10 ZCCHC12 ZFTRAF1 ZNF131 ZNF76 ZNF764
Entrez ID		2512	3839
HPRD ID		00616	03536
Ensembl ID		ENSG00000087086	ENSG00000102753
Uniprot IDs		A0A384MDR3 P02792	O00505
PDB IDs		2FFX 2FG4 2FG8 3KXU 4V6B 5LG8 6TR9 6TS0 6TS1 6TSA 6TSF 6TSJ 6WX6
Enriched GO Terms of Interacting Partners?			Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To Estradiol Stimulus Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Response To Oxidative Stress Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Protein Modification Process Negative Regulation Of DNA-templated Transcription Transcription Coactivator Binding Negative Regulation Of RNA Biosynthetic Process DNA Binding Negative Regulation Of Macromolecule Metabolic Process Nucleotide-excision Repair DNA-binding Transcription Factor Activity Gene Expression Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Cellular Response To Oxidative Stress Cellular Senescence Cellular Response To Oxygen-containing Compound Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process DNA Double-strand Break Processing Embryonic Placenta Development Macromolecule Biosynthetic Process
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