FTL and FTH1

Number of citations of the paper that reports this interaction (PMID 11591653)
37

Data Source:
HPRD (in vivo)

		FTL	FTH1
Gene Name		ferritin, light polypeptide	ferritin, heavy polypeptide 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Intracellular Ferritin Complex Membrane Extracellular Vesicular Exosome	Nucleus Mitochondrion Cytosol Intracellular Ferritin Complex Extracellular Vesicular Exosome
	Molecular Function	Iron Ion Binding Protein Binding Ferric Iron Binding Identical Protein Binding	Ferroxidase Activity Iron Ion Binding Protein Binding Ferric Iron Binding
	Biological Process	Iron Ion Transport Cellular Iron Ion Homeostasis Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Iron Ion Homeostasis Transmembrane Transport Membrane Organization	Iron Ion Transport Cellular Iron Ion Homeostasis Intracellular Sequestering Of Iron Ion Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Immune Response Negative Regulation Of Cell Proliferation Negative Regulation Of Fibroblast Proliferation Transmembrane Transport Oxidation-reduction Process Membrane Organization
Pathways		Iron uptake and transport Golgi Associated Vesicle Biogenesis Scavenging by Class A Receptors trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding	Iron uptake and transport Golgi Associated Vesicle Biogenesis Scavenging by Class A Receptors trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs		Iron Dextran Protoporphyrin Ix	Iron Dextran
Diseases
GWAS			Estradiol levels ( 22675492) Phospholipid levels (plasma) ( 21829377)
Protein-Protein Interactions		24 interactors: CLEC4G FTH1 GADD45A GRB2 HTT IGDCC3 KNG1 KPNA3 MAP3K12 MPHOSPH6 MPP6 MYOC MYOG PIK3CA PPP1CC PTN RAP2A SDCBP SMAD9 SPINK7 TAF10 USHBP1 VKORC1 ZDHHC17	31 interactors: BRD7 CD99 CDC16 CDC25A CRMP1 CSF3R CSNK2B DAXX ELL3 FTL FXR2 GOLM1 GRB2 KPNA2 LBP MAX MYL3 NR1I3 NR3C1 NR5A2 PACSIN1 PIAS4 SDCBP SOX5 SPP1 TICAM2 TOLLIP TRAF4 UBR1 WDYHV1 YWHAE
Entrez ID		2512	2495
HPRD ID		00616	00615
Ensembl ID		ENSG00000087086	ENSG00000167996
Uniprot IDs		P02792	P02794
PDB IDs		2FFX 2FG4 2FG8 3HX2 3HX5 3HX7 3KXU	1FHA 2CEI 2CHI 2CIH 2CLU 2CN6 2CN7 2FHA 2IU2 2Z6M 3AJO 3AJP 3AJQ 3ERZ 3ES3 4DYX 4DYY 4DYZ 4DZ0
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Regulation Of Phosphorus Metabolic Process Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Muscle System Process Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Maturation Of 5.8S RRNA Cellular Response To Growth Factor Stimulus Signal Transduction Response To Growth Factor Response To Abiotic Stimulus Signaling Regulation Of Metabolic Process Cellular Response To Stimulus Regulation Of Signal Transduction Cell Communication ERBB Signaling Pathway Regulation Of JNK Cascade Blood Coagulation Hemostasis Regulation Of Stress-activated MAPK Cascade Response To Radiation Platelet Activation Membrane Organization Positive Regulation Of Phosphorylation Regulation Of Signaling Intracellular Signal Transduction Neural Plate Formation Skeletal Muscle Hypertrophy Positive Regulation Of Muscle Atrophy ERBB2-ERBB3 Signaling Pathway Ras Protein Signal Transduction Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Cellular Component Assembly Bone Development Positive Regulation Of Cellular Metabolic Process Cellular Response To Ionizing Radiation Regulation Of Body Fluid Levels Hypomethylation Of CpG Island Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Intracellular Sequestering Of Iron Ion Serotonin Uptake ERBB2 Signaling Pathway Lactate Biosynthetic Process From Pyruvate Viral Penetration Into Host Nucleus Positive Regulation Of Metabolic Process	Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Metabolic Process Cellular Response To Stimulus Regulation Of Metabolic Process Chemotaxis Positive Regulation Of Signal Transduction Hormone-mediated Signaling Pathway Response To Stimulus Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Cell Communication Regulation Of Protein Metabolic Process System Development Movement Of Cell Or Subcellular Component Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Generation Of Neurons Anatomical Structure Development Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Toll-like Receptor Signaling Pathway Locomotion Positive Regulation Of Protein Sumoylation Signaling Response To Hormone Neurogenesis Cellular Response To Lipid Leukocyte Migration Signal Transduction Regulation Of Signaling Steroid Hormone Mediated Signaling Pathway Multicellular Organismal Development Regulation Of Protein Sumoylation Response To External Stimulus Leukocyte Chemotaxis Regulation Of Cellular Process Positive Regulation Of Cellular Protein Metabolic Process Developmental Process Positive Regulation Of JNK Cascade Cell Migration Response To Lipid Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Transcription From RNA Polymerase II Promoter Cell Motility Negative Regulation Of Gene Expression
Tagcloud ?		apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39 tnnt1	aggravating anxa1 banks bedside confidently cons ftl gliosis got2 immunochemical infarct infarcted infarcts itraq lagging leak malate mdh2 mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim
Tagcloud (Difference) ?		apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39 tnnt1	aggravating anxa1 banks bedside confidently cons ftl gliosis got2 immunochemical infarct infarcted infarcts itraq lagging leak malate mdh2 mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim
Tagcloud (Intersection) ?