FTL and FTH1

Number of citations of the paper that reports this interaction (PubMedID 11591653)
29

Data Source:
HPRD (in vivo)

		FTL	FTH1
Description		ferritin light chain	ferritin heavy chain 1
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Autophagosome Cytosol Membrane Cytoplasmic Vesicle Azurophil Granule Lumen Autolysosome Extracellular Exosome Ferritin Complex	Extracellular Region Nucleus Cytoplasm Lysosome Autophagosome Cytosol Cytoplasmic Vesicle Autolysosome Extracellular Exosome Ferritin Complex Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Iron Ion Binding Protein Binding Ferrous Iron Binding Ferric Iron Binding Identical Protein Binding Metal Ion Binding	Ferroxidase Activity Iron Ion Binding Protein Binding Ferrous Iron Binding Ferric Iron Binding Oxidoreductase Activity Identical Protein Binding Metal Ion Binding Iron Ion Sequestering Activity
	Biological Process	Iron Ion Transport Intracellular Iron Ion Homeostasis	Iron Ion Transport Intracellular Iron Ion Homeostasis Immune Response Negative Regulation Of Cell Population Proliferation Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Ferroptosis
Pathways		Scavenging by Class A Receptors Golgi Associated Vesicle Biogenesis Neutrophil degranulation Iron uptake and transport	Scavenging by Class A Receptors Golgi Associated Vesicle Biogenesis Neutrophil degranulation Iron uptake and transport
Drugs		Iron Dextran Protoporphyrin Ferric pyrophosphate Sodium ferric gluconate complex Ferric pyrophosphate citrate	Iron Dextran Iron Ferric pyrophosphate citrate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases		Neurodegeneration with brain iron accumulation (NBIA); Hallervorden-Spatz syndrome; Neuroferritinopathy; Aceruloplasminemia
GWAS			Estradiol levels ( 22675492) Major depressive disorder x sex interaction ( 34099189) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189)
Interacting Genes		31 interacting genes: ACO1 CLEC4G FTH1 GADD45A GLP1R GRB2 HTT IGDCC3 KNG1 KPNA3 MAP3K12 MEOX2 MPHOSPH6 MTNR1B MYOC MYOG NTAQ1 PALS2 PIK3CA PPP1CC PTN RAP2A SDCBP SLC13A1 SMAD9 SPINK7 TAF10 UBC USHBP1 VKORC1 ZDHHC17	42 interacting genes: BAG4 BRD7 CD99 CDC16 CDC25A CDC42 CRMP1 CSF3R CSNK2B DAXX DLG4 ELL3 FTL FXR1 FXR2 GOLM1 GPR35 GRB2 KPNA2 LBP MAX MYL3 NR1I3 NR3C1 NR5A2 NTAQ1 OPTN PACSIN1 PCBP1 PCBP2 PIAS4 SDCBP SIRPA SNCA SOX5 SPP1 STAT1 TICAM2 TOLLIP TRAF4 UBR1 YWHAE
Entrez ID		2512	2495
HPRD ID		00616	00615
Ensembl ID		ENSG00000087086	ENSG00000167996
Uniprot IDs		A0A384MDR3 P02792	P02794
PDB IDs		2FFX 2FG4 2FG8 3KXU 4V6B 5LG8 6TR9 6TS0 6TS1 6TSA 6TSF 6TSJ 6WX6	1FHA 2CEI 2CHI 2CIH 2CLU 2CN6 2CN7 2FHA 2IU2 2Z6M 3AJO 3AJP 3AJQ 3ERZ 3ES3 4DYX 4DYY 4DYZ 4DZ0 4OYN 4Y08 4YKH 4ZJK 5CMQ 5CMR 5GN8 5GOU 5JKK 5JKL 5JKM 5N26 5N27 5UP7 5UP8 5UP9 5VTD 5XB1 5YI5 5ZND 6B8F 6B8G 6FTV 6GSR 6H5I 6H6T 6H6U 6IPC 6IPO 6IPP 6IPQ 6J4A 6J7G 6JOB 6JPS 6KE2 6KE4 6M52 6M54 6WYF 6WYG 6WYH 6Z6U 6Z9E 6Z9F 7A6A 7A6B 7CK8 7CK9 7JGK 7JGL 7JGM 7JGN 7JGO 7JGP 7JGQ 7K26 7K3V 7K3W 7KE3 7KE5 7PF1 7R5O 7RRP 7V66 7VD8 7ZG7 8A2L 8A2M 8A5N 8AAV 8B7O 8CPM 8CPS 8CPT 8CPU 8CPV 8CPW 8CPX 8DHX 8DNP 8F49 8F4L 8HHS 8J9L 8J9M 8JAI 8KFD 8PP2 8PP3 8PP5 8QU9 8W92 8WB3 8WIE 8WIQ 8WJF 8XWB 8Y6F 9JIU 9JQB 9JQC 9JQD 9JQE 9KAY
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Metabolic Process Cytosol Regulation Of Long-term Neuronal Synaptic Plasticity Signal Transduction Cytoplasm Regulation Of Defense Response Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Communication Negative Regulation Of Transport Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Metabolic Process Regulation Of Neuronal Synaptic Plasticity Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Identical Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Cell Communication Intracellular Receptor Signaling Pathway Postsynapse Negative Regulation Of Endocytosis Regulation Of Signaling Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Localization Within Membrane Cytoplasmic Ribonucleoprotein Granule Regulation Of Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Signaling Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Protein Phosphatase Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Response To Type II Interferon Regulation Of Endocytosis Phosphoprotein Binding Viral RNA Genome Replication Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein Kinase Binding Immune System Process Regulation Of Canonical NF-kappaB Signal Transduction Dendrite Positive Regulation Of Biosynthetic Process Protein Sequestering Activity Protein-macromolecule Adaptor Activity Neuron Projection Lipid Binding Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cell Adhesion Regulation Of Primary Metabolic Process
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