FTL and KNG1

Number of citations of the paper that reports this interaction (PMID 12071855)
6

Data Source:
HPRD (in vitro)

		FTL	KNG1
Gene Name		ferritin, light polypeptide	kininogen 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Intracellular Ferritin Complex Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Plasma Membrane Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Iron Ion Binding Protein Binding Ferric Iron Binding Identical Protein Binding	Cysteine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Heparin Binding Zinc Ion Binding
	Biological Process	Iron Ion Transport Cellular Iron Ion Homeostasis Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Iron Ion Homeostasis Transmembrane Transport Membrane Organization	Platelet Degranulation Smooth Muscle Contraction Inflammatory Response Negative Regulation Of Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Platelet Activation Negative Regulation Of Blood Coagulation Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Vasodilation Positive Regulation Of Apoptotic Process Negative Regulation Of Proteolysis
Pathways		Iron uptake and transport Golgi Associated Vesicle Biogenesis Scavenging by Class A Receptors trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Platelet degranulation Metabolic disorders of biological oxidation enzymes GPCR ligand binding Formation of Fibrin Clot (Clotting Cascade) G alpha (q) signalling events GPCR downstream signaling Intrinsic Pathway Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ G alpha (i) signalling events Platelet activation, signaling and aggregation
Drugs		Iron Dextran Protoporphyrin Ix
Diseases
GWAS			Activated partial thromboplastin time ( 22703881 20303064) Adiponectin levels ( 20876611)
Protein-Protein Interactions		24 interactors: CLEC4G FTH1 GADD45A GRB2 HTT IGDCC3 KNG1 KPNA3 MAP3K12 MPHOSPH6 MPP6 MYOC MYOG PIK3CA PPP1CC PTN RAP2A SDCBP SMAD9 SPINK7 TAF10 USHBP1 VKORC1 ZDHHC17	28 interactors: AGT APP CAPN1 CAPN2 CD93 CPN1 CTSG CTSK CTSL CTSS ECE1 ELANE F11 F2 FTL GP1BA HABP2 ITGB2 KLK1 KLKB1 KRT1 MEP1A PLAUR PLG PREP RXFP4 THBS1 VTN
Entrez ID		2512	3827
HPRD ID		00616	01970
Ensembl ID		ENSG00000087086
Uniprot IDs		P02792	P01042
PDB IDs		2FFX 2FG4 2FG8 3HX2 3HX5 3HX7 3KXU	2WOK 4ASQ 4ASR 4ECB 4ECC
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Regulation Of Phosphorus Metabolic Process Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Muscle System Process Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Maturation Of 5.8S RRNA Cellular Response To Growth Factor Stimulus Signal Transduction Response To Growth Factor Response To Abiotic Stimulus Signaling Regulation Of Metabolic Process Cellular Response To Stimulus Regulation Of Signal Transduction Cell Communication ERBB Signaling Pathway Regulation Of JNK Cascade Blood Coagulation Hemostasis Regulation Of Stress-activated MAPK Cascade Response To Radiation Platelet Activation Membrane Organization Positive Regulation Of Phosphorylation Regulation Of Signaling Intracellular Signal Transduction Neural Plate Formation Skeletal Muscle Hypertrophy Positive Regulation Of Muscle Atrophy ERBB2-ERBB3 Signaling Pathway Ras Protein Signal Transduction Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Cellular Component Assembly Bone Development Positive Regulation Of Cellular Metabolic Process Cellular Response To Ionizing Radiation Regulation Of Body Fluid Levels Hypomethylation Of CpG Island Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Intracellular Sequestering Of Iron Ion Serotonin Uptake ERBB2 Signaling Pathway Lactate Biosynthetic Process From Pyruvate Viral Penetration Into Host Nucleus Positive Regulation Of Metabolic Process	Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Blood Coagulation Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Wound Healing Proteolysis Extracellular Matrix Disassembly Fibrinolysis Regulation Of Fibrinolysis Protein Metabolic Process Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Response To Stress Blood Coagulation, Intrinsic Pathway Positive Regulation Of Fibrinolysis Defense Response Wound Healing Response To Wounding Negative Regulation Of Fibrinolysis Immune System Process Protein Processing Positive Regulation Of Wound Healing Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Cell Activation Regulation Of Inflammatory Response Collagen Catabolic Process Immune Response Protein Activation Cascade Collagen Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Platelet Activation Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Protein Processing Positive Regulation Of Immune Response Positive Regulation Of Blood Coagulation Toll-like Receptor Signaling Pathway Peptide Hormone Processing Regulation Of Immune System Process Bradykinin Catabolic Process Positive Regulation Of Coagulation Pattern Recognition Receptor Signaling Pathway Regulation Of Protein Metabolic Process
Tagcloud ?		apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39 tnnt1	ace ace2 agt agtr1 agtr2 allele arrhythmias bdkrb2 converting correction county descent european gender genotyped haplotype haplotypes king ren replicated rs1492099 rs710448 sca snp snps sudden variation variations washington
Tagcloud (Difference) ?		apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39 tnnt1	ace ace2 agt agtr1 agtr2 allele arrhythmias bdkrb2 converting correction county descent european gender genotyped haplotype haplotypes king ren replicated rs1492099 rs710448 sca snp snps sudden variation variations washington
Tagcloud (Intersection) ?