FTL and ACO1

Number of citations: 0 (PubMedID 8764614)
Data Source: BioGRID (unspecified method)

		FTL	ACO1
Name		ferritin light chain	aconitase 1
Structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Autophagosome Cytosol Membrane Cytoplasmic Vesicle Azurophil Granule Lumen Autolysosome Extracellular Exosome Ferritin Complex	Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Extracellular Exosome
	Molecular Function	Iron Ion Binding Protein Binding Ferrous Iron Binding Ferric Iron Binding Identical Protein Binding Metal Ion Binding	MRNA Regulatory Element Binding Translation Repressor Activity RNA Binding Aconitate Hydratase Activity Protein Binding Lyase Activity Iron-responsive Element Binding Metal Ion Binding Iron-sulfur Cluster Binding 3 Iron, 4 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Iron Ion Transport Intracellular Iron Ion Homeostasis	Tricarboxylic Acid Cycle Citrate Metabolic Process Regulation Of Translation NADPH Regeneration Intracellular Iron Ion Homeostasis Post-embryonic Development Response To Iron(II) Ion Regulation Of Gene Expression Negative Regulation Of Translation Intestinal Absorption
Pathways		Scavenging by Class A Receptors Golgi Associated Vesicle Biogenesis Neutrophil degranulation Iron uptake and transport	NADPH regeneration Iron uptake and transport
Drugs		Iron Dextran Protoporphyrin Ferric pyrophosphate Sodium ferric gluconate complex Ferric pyrophosphate citrate	None
Diseases		Neurodegeneration with brain iron accumulation (NBIA); Hallervorden-Spatz syndrome; Neuroferritinopathy; Aceruloplasminemia	None
GWAS		No GWAS studies recorded	Asthma ( 22561531 ) Hematocrit ( 27863252 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 32327693 ) Immune response to measles-mumps-rubella vaccine ( 24811271 ) Inflammatory skin disease ( 25574825 ) Lateral ventricle temporal horn volume ( 31530798 ) Motion sickness ( 25628336 ) Red blood cell count ( 27863252 32888494 ) Smoking status (ever vs never smokers) ( 30643258 )
Interacting Genes		31 interacting genes: ACO1 CLEC4G FTH1 GADD45A GLP1R GRB2 HTT IGDCC3 KNG1 KPNA3 MAP3K12 MEOX2 MPHOSPH6 MTNR1B MYOC MYOG NTAQ1 PALS2 PIK3CA PPP1CC PTN RAP2A SDCBP SLC13A1 SMAD9 SPINK7 TAF10 UBC USHBP1 VKORC1 ZDHHC17	10 interacting genes: APP CCDC69 CDC42 CLTC DSCAM FTL MYBPC1 NEB PXN RNF10
Entrez ID		2512	48
HPRD ID		00616	00013
Ensembl ID		ENSG00000087086	ENSG00000122729
Uniprot IDs		A0A384MDR3 P02792	P21399 Q9HBB2 V9HWB7
PDB IDs		2FFX 2FG4 2FG8 3KXU 4V6B 5LG8 6TR9 6TS0 6TS1 6TSA 6TSF 6TSJ 6WX6	2B3X 2B3Y
GO Terms Enriched among Interactors		None	Amyloid-beta Complex Cell Projection Morphogenesis Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Response To Calcium Ion Low-density Lipoprotein Particle Receptor Binding Amylin Binding Neuron Projection Morphogenesis Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Neuron Recognition Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Spindle Spindle Midzone Positive Regulation Of Actin Filament Bundle Assembly Iron Ion Transport Myofibril Structural Constituent Of Muscle Acetylcholine Receptor Activator Activity Regulation Of Cellular Component Organization Cellular Component Assembly Clathrin-coated Pit Cell Adhesion Lipoprotein Particle Positive Regulation Of Protein Import Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process GBD Domain Binding Storage Vacuole Cytoskeleton Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Ferritin Complex Regulation Of Supramolecular Fiber Organization PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cell Recognition Lysosome Dendrite Trans-Golgi Network Membrane Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Neuron Projection Development Endocytosis