ALOX12 and PLA2G2A

Number of citations of the paper that reports this interaction (PMID 15474031)
4

Data Source:
HPRD (in vivo)

		ALOX12	PLA2G2A
Gene Name		arachidonate 12-lipoxygenase	phospholipase A2, group IIA (platelets, synovial fluid)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Membrane Sarcolemma Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Secretory Granule Extracellular Vesicular Exosome
	Molecular Function	Arachidonate 12-lipoxygenase Activity Iron Ion Binding Protein Binding Linoleate 13S-lipoxygenase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hepoxilin-epoxide Hydrolase Activity Hepoxilin A3 Synthase Activity	Phospholipase A2 Activity Calcium Ion Binding Phospholipid Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Movement Of Cell Or Subcellular Component Aging Positive Regulation Of Cell Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Muscle Cell Apoptotic Process Arachidonic Acid Metabolic Process Lipoxygenase Pathway Fatty Acid Oxidation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Superoxide Anion Generation Negative Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Linoleic Acid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Vasodilation Positive Regulation Of Smooth Muscle Cell Proliferation Hepoxilin Metabolic Process Hepoxilin Biosynthetic Process Positive Regulation Of Mitochondrial Depolarization Establishment Of Skin Barrier Cellular Response To Lipid Reactive Oxygen Species Metabolic Process Negative Regulation Of Platelet Aggregation Leukotriene A4 Metabolic Process Lipoxin Metabolic Process Lipoxin A4 Biosynthetic Process Lipoxin B4 Biosynthetic Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation Lipid Catabolic Process Low-density Lipoprotein Particle Remodeling Somatic Stem Cell Maintenance Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Small Molecule Metabolic Process Phosphatidic Acid Metabolic Process Glycerophospholipid Biosynthetic Process Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium
Pathways		Arachidonic acid metabolism Metabolism of lipids and lipoproteins Synthesis of Lipoxins (LX) Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of Hepoxilins (HX) and Trioxilins (TrX)	Acyl chain remodelling of PG Acyl chain remodelling of PE Synthesis of PA Metabolism of lipids and lipoproteins Acyl chain remodelling of PI Phospholipid metabolism Glycerophospholipid biosynthesis Acyl chain remodelling of PC Acyl chain remodelling of PS
Drugs			Indomethacin Diclofenac Ginkgo biloba 1,4-Butanediol 1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene N-Tridecanoic Acid [3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid 4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid 1-Benzyl-5-Methoxy-2-Methyl-1h-Indol-3-Yl)-Acetic Acid 6-Phenyl-4(R)-(7-Phenyl-Heptanoylamino)-Hexanoic Acid Elaidoylamide 1-Octadecyl-2-Acetamido-2-Deoxy-Sn-Glycerol-3-Phosphoethylmethyl Sulfide (S)-5-(4-Benzyloxy-Phenyl)-4-(7-Phenyl-Heptanoylamino)-Pentanoic Acid Suramin
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ITGB4 KAT5 KRT5 KRT85 LMNA PLA2G2A TRIB1	24 interactors: ALOX12 BAG6 CEP70 CRMP1 DCN JOSD2 PLA2G1B PLA2R1 SENP6 SENP8 UCHL1 UCHL3 UCHL5 USP15 USP2 USP20 USP28 USP4 USP47 USP5 USP7 USP8 VCAN VIM
Entrez ID		239	5320
HPRD ID		01066	01397
Ensembl ID		ENSG00000108839	ENSG00000188257
Uniprot IDs		P18054	P14555
PDB IDs		2ABU 3D3L	1AYP 1BBC 1DB4 1DB5 1DCY 1J1A 1KQU 1KVO 1N28 1N29 1POD 1POE 2GNY 3U8B 3U8D 3U8H 3U8I
Enriched GO Terms of Interacting Partners?		Hemidesmosome Assembly Cell-substrate Junction Assembly Sterol Regulatory Element Binding Protein Import Into Nucleus	Protein Modification By Small Protein Removal Protein Deubiquitination Regulation Of Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Catabolic Process Proteolysis Regulation Of Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein K48-linked Deubiquitination Cellular Metabolic Process Monoubiquitinated Protein Deubiquitination Dermatan Sulfate Biosynthetic Process Regulation Of Phospholipase A2 Activity Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Protein K63-linked Deubiquitination Histone Deubiquitination Chondroitin Sulfate Biosynthetic Process Metabolic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Regulation Of Protein Stability Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Leukotriene Metabolic Process Cellular Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Cellular Protein Metabolic Process Icosanoid Biosynthetic Process Negative Regulation Of Arachidonic Acid Secretion Lipoxin B4 Biosynthetic Process Leukotriene A4 Metabolic Process Cellular Response To DNA Damage Stimulus Unsaturated Fatty Acid Biosynthetic Process Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Negative Regulation Of Protein Metabolic Process
Tagcloud ?		agxt aim2 built cpg discriminate discriminated e85 epigenome false il10 jak3 lcn2 leukocyte manifested methqtl obtainable p1075 p180 p220 p348 p624 p817 p86 pac penalized resectable smoker statistic zap70	1p35 adenomas adenomatous alleles borderline characterised colonic disequilibrium duodenal fap genuine inherited locus modifier modify mom1 noncoding p36 phospholipase pla2s polymorphic polyposis polyps secretory silent sporadic syntenic undetected
Tagcloud (Difference) ?		agxt aim2 built cpg discriminate discriminated e85 epigenome false il10 jak3 lcn2 leukocyte manifested methqtl obtainable p1075 p180 p220 p348 p624 p817 p86 pac penalized resectable smoker statistic zap70	1p35 adenomas adenomatous alleles borderline characterised colonic disequilibrium duodenal fap genuine inherited locus modifier modify mom1 noncoding p36 phospholipase pla2s polymorphic polyposis polyps secretory silent sporadic syntenic undetected
Tagcloud (Intersection) ?