ALOX12 and KRT85

Number of citations of the paper that reports this interaction (PubMedID 10727209)
0

Data Source:
HPRD (two hybrid)

		ALOX12	KRT85
Description		arachidonate 12-lipoxygenase, 12S type	keratin 85
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Sarcolemma Extracellular Exosome	Extracellular Space Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Arachidonate 12(S)-lipoxygenase Activity Iron Ion Binding Protein Binding Linoleate 13S-lipoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hydrolase Activity Metal Ion Binding Hepoxilin-epoxide Hydrolase Activity Arachidonate 15-lipoxygenase Activity Dioxygenase Activity	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Negative Regulation Of Muscle Cell Apoptotic Process Arachidonate Metabolic Process Lipoxygenase Pathway Fatty Acid Oxidation Unsaturated Fatty Acid Metabolic Process Lipid Oxidation Superoxide Anion Generation Long-chain Fatty Acid Biosynthetic Process Linoleic Acid Metabolic Process Hepoxilin Biosynthetic Process Establishment Of Skin Barrier Negative Regulation Of Platelet Aggregation Leukotriene A4 Metabolic Process Lipoxin A4 Biosynthetic Process Lipoxin B4 Biosynthetic Process	Epidermis Development Keratinization Intermediate Filament Organization
Pathways		Synthesis of Hepoxilins (HX) and Trioxilins (TrX) Biosynthesis of Lipoxins (LX) Synthesis of 12-eicosatetraenoic acid derivatives Biosynthesis of DHA-derived SPMs Biosynthesis of DPAn-6 SPMs Biosynthesis of DPAn-3-derived maresins	Keratinization Formation of the cornified envelope
Drugs
Diseases			Ectodermal dysplasia, pure hair-nail type (HNED)
GWAS		Mean platelet volume ( 32888494)	Body mass index ( 28552196)
Interacting Genes		7 interacting genes: ITGB4 KAT5 KRT5 KRT85 LMNA PLA2G2A TRIB1	27 interacting genes: ALOX12 CLIC3 CREB5 CYSRT1 GNE HAPLN2 KLHL38 KRT13 KRT14 KRT15 KRT16 KRT19 KRT25 KRT26 KRT27 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT39 KRT40 LHX8 OTX1 TAB2 ZNF655
Entrez ID		239	3891
HPRD ID		01066	04139
Ensembl ID		ENSG00000108839	ENSG00000135443
Uniprot IDs		P18054	B7Z7N3 F5GYI5 P78386
PDB IDs		3D3L 8GHB 8GHC 8GHD 8GHE
Enriched GO Terms of Interacting Partners?		Intermediate Filament Phosphatidylethanolamine Metabolic Process Peripheral Nervous System Myelin Formation Structural Constituent Of Cytoskeleton Intermediate Filament Polymerization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament Polymerization Or Depolymerization Keratinization Keratin Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Organization DNA Double-strand Break Attachment To Nuclear Envelope Nuclear Lumen Site Of Double-strand Break Negative Regulation Of Multicellular Organismal Process Structural Constituent Of Nuclear Lamina Cellular Senescence Phosphatidylcholine Metabolic Process Positive Regulation Of Eosinophil Differentiation Negative Regulation Of Neutrophil Differentiation Histone H2AK5 Acetyltransferase Activity Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Histone H2A Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Epidermis Development Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Piccolo Histone Acetyltransferase Complex Hemidesmosome Assembly Nail Development Neuregulin Binding Tissue Development Structural Molecule Activity Negative Regulation Of Cell Population Proliferation Lamin Filament Perinuclear Region Of Cytoplasm Nuclear Pore Localization Intestinal Stem Cell Homeostasis Ubiquitin-protein Transferase Regulator Activity Positive Regulation Of Protein Acetylation Positive Regulation Of Aggrephagy Positive Regulation Of Leukocyte Differentiation Trophoblast Cell Migration Lipid Droplet Disassembly Hemidesmosome Negative Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Granulocyte Differentiation	Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Structural Molecule Activity Morphogenesis Of An Epithelium Epithelial Cell Differentiation Tissue Morphogenesis Supramolecular Fiber Organization Cytoskeleton Organization Anatomical Structure Morphogenesis Cytoskeleton Extracellular Exosome Epidermis Development Cell Differentiation Hair Cycle Cellular Developmental Process Developmental Process Organelle Organization Structural Constituent Of Cytoskeleton Establishment Of Skin Barrier Skin Epidermis Development Cytosol Tissue Development Cornified Envelope Hair Follicle Morphogenesis Hepoxilin-epoxide Hydrolase Activity Lipoxin B4 Biosynthetic Process Protein Binding Diencephalon Morphogenesis N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine 2-epimerase Activity Leukotriene A4 Metabolic Process Lipoxin B4 Metabolic Process Linoleate 13S-lipoxygenase Activity Arachidonate 15-lipoxygenase Activity Lipoxin A4 Biosynthetic Process Intermediate Filament Cytoskeleton Protein-disulfide Reductase (glutathione) Activity N-acylmannosamine Kinase Activity N-acetylneuraminate Biosynthetic Process Lipoxin Biosynthetic Process Lipoxin A4 Metabolic Process Arachidonate 12(S)-lipoxygenase Activity Keratinocyte Differentiation Terminal Web Metencephalon Development Establishment Of Blood-nerve Barrier
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