PISD and CIDEB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PISD	CIDEB
Description		phosphatidylserine decarboxylase	cell death inducing DFFA like effector b
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Golgi Apparatus Lipid Droplet Cytosol Membrane	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Cytosol Membrane COPII Vesicle Coat COPI-coated Vesicle Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphatidylserine Decarboxylase Activity Protein Binding Lyase Activity Carboxy-lyase Activity	Protein Binding Identical Protein Binding Molecular Adaptor Activity Phosphatidic Acid Binding Lipid Transfer Activity
	Biological Process	Lipid Metabolic Process Phosphatidylethanolamine Biosynthetic Process Phospholipid Biosynthetic Process Regulation Of Mitochondrion Organization Protein Autoprocessing Mitochondrial Protein Catabolic Process Lipid Droplet Formation	Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Lipid Storage Response To Nutrient Levels Very-low-density Lipoprotein Particle Assembly Positive Regulation Of Apoptotic Process COPII-coated Vesicle Cargo Loading Regulation Of Triglyceride Metabolic Process Execution Phase Of Apoptosis Intermembrane Lipid Transfer Lipid Droplet Fusion
Pathways		Synthesis of PE
Drugs		Phosphatidyl serine
Diseases
GWAS		Age-related hearing impairment ( 24939585) Fish- and plant-related diet ( 32066663) Intelligence ( 22449649) Oily fish consumption ( 32066663) Paclitaxel-induced neuropathy ( 23776197) Pork consumption ( 32066663)	Anorectal malformation ( 31136621) Height ( 28552196) Parent of origin effect on language impairment (paternal) ( 24571439)
Interacting Genes		6 interacting genes: BRCA1 CFTR CIDEB DAGLB DHX29 UBC	68 interacting genes: ABHD16A AFG1L APOC1 ARL8B ATP5ME ATP5MJ BCL2L2 CAND2 CIDEA CLCN1 CMPK1 COL10A1 COL8A1 COX7C DFFA DFFB DHRSX DNAJA3 FAM218A FAM47E-STBD1 FKBP8 FOXD4L3 FUNDC2 GCSH GNB3 GPAM H4C7 HAPLN2 HCCS HIGD1C IRX2-DT MEST MICOS10 MPC2 MRPL36 MRPL57 MTERF4 NAALAD2 NDRG4 NFU1 NME4 PBX3 PDHX PGLYRP3 PISD PPIF RAMP2 RHBDD2 ROMO1 RTP5 SAA2 SAA4 SAR1B SCO1 SCO2 SDHAF1 SFXN1 SMARCC1 SPG21 TAOK2 TBX2 TEX44 THBD TIMM17B TMEM14B TPRG1 TSR1 UFSP1
Entrez ID		23761	27141
HPRD ID		17854	11981
Ensembl ID		ENSG00000241878	ENSG00000136305
Uniprot IDs		Q9UG56	Q9UHD4
PDB IDs			1D4B
Enriched GO Terms of Interacting Partners?		Regulation Of Lipid Metabolic Process Small Molecule Biosynthetic Process Histone H2AK127 Ubiquitin Ligase Activity Fatty Acid Biosynthetic Process Histone H2AK129 Ubiquitin Ligase Activity Lipid Biosynthetic Process BRCA1-BARD1 Complex Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Triglyceride Metabolic Process Positive Regulation Of Monoatomic Anion Transport Cannabinoid Biosynthetic Process BRCA1-B Complex Positive Regulation Of Enamel Mineralization Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Centriole Replication BRCA1-A Complex Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol BRCA1-C Complex Ubiquitin-modified Histone Reader Activity Response To Indole-3-methanol Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Lipid Droplet Fusion Formation Of Translation Preinitiation Complex Positive Regulation Of Triglyceride Catabolic Process Diacylglycerol Catabolic Process Monoacylglycerol Biosynthetic Process Negative Regulation Of Centrosome Duplication Lipid Metabolic Process XY Body Fatty Acid Metabolic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Lateral Element Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gamma-tubulin Ring Complex Apoptotic Signaling Pathway Ubiquitin Protein Ligase Binding DNA Strand Resection Involved In Replication Fork Processing Response To Alcohol	Mitochondrion Mitochondrial Inner Membrane Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of Apoptotic DNA Fragmentation High-density Lipoprotein Particle Protein Binding Mitochondrion Organization Mitochondrial Membrane Copper Chaperone Activity Disordered Domain Specific Binding T Cell Apoptotic Process Mitochondrial Matrix Organophosphate Biosynthetic Process Cytochrome Complex Assembly Pyruvate Decarboxylation To Acetyl-CoA Activation-induced Cell Death Of T Cells Mitochondrial Respiratory Chain Complex Assembly Lymphocyte Apoptotic Process Import Into The Mitochondrion Negative Regulation Of Execution Phase Of Apoptosis Protein Localization To Mitochondrion
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