PISD and DAGLB

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PISD	DAGLB
Description		phosphatidylserine decarboxylase	diacylglycerol lipase beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Golgi Apparatus Lipid Droplet Cytosol Membrane	Nucleoplasm Lysosomal Membrane Plasma Membrane Membrane
	Molecular Function	Phosphatidylserine Decarboxylase Activity Protein Binding Lyase Activity Carboxy-lyase Activity	Triacylglycerol Lipase Activity Protein Binding Lipase Activity Hydrolase Activity Metal Ion Binding Monoacylglycerol Lipase Activity
	Biological Process	Lipid Metabolic Process Phosphatidylethanolamine Biosynthetic Process Phospholipid Biosynthetic Process Regulation Of Mitochondrion Organization Protein Autoprocessing Mitochondrial Protein Catabolic Process Lipid Droplet Formation	Prostaglandin Biosynthetic Process Lipid Metabolic Process Monoacylglycerol Biosynthetic Process Icosanoid Metabolic Process Neuroblast Proliferation Positive Regulation Of Triglyceride Catabolic Process Lipid Catabolic Process Arachidonate Metabolic Process Neurogenesis Diacylglycerol Catabolic Process Regulation Of Inflammatory Response Cannabinoid Biosynthetic Process
Pathways		Synthesis of PE	Arachidonate production from DAG
Drugs		Phosphatidyl serine
Diseases
GWAS		Age-related hearing impairment ( 24939585) Fish- and plant-related diet ( 32066663) Intelligence ( 22449649) Oily fish consumption ( 32066663) Paclitaxel-induced neuropathy ( 23776197) Pork consumption ( 32066663)	Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Body mass index ( 26426971) Coronary artery disease ( 29212778) HDL cholesterol ( 24097068 30275531) HDL cholesterol levels ( 32203549 28334899) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 33339817) Inflammatory bowel disease ( 28067908) Lymphocyte percentage of white cells ( 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 27863252) Red cell distribution width ( 32888494) Ulcerative colitis ( 28067908) Waist-hip ratio and HDL-C (pairwise) ( 33619380) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		6 interacting genes: BRCA1 CFTR CIDEB DAGLB DHX29 UBC	5 interacting genes: CLP1 KRTAP1-3 NBPF19 NOTCH2NLA PISD
Entrez ID		23761	221955
HPRD ID		17854	17324
Ensembl ID		ENSG00000241878	ENSG00000164535
Uniprot IDs		Q9UG56	Q8NCG7
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Lipid Metabolic Process Small Molecule Biosynthetic Process Histone H2AK127 Ubiquitin Ligase Activity Fatty Acid Biosynthetic Process Histone H2AK129 Ubiquitin Ligase Activity Lipid Biosynthetic Process BRCA1-BARD1 Complex Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Triglyceride Metabolic Process Positive Regulation Of Monoatomic Anion Transport Cannabinoid Biosynthetic Process BRCA1-B Complex Positive Regulation Of Enamel Mineralization Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Centriole Replication BRCA1-A Complex Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol BRCA1-C Complex Ubiquitin-modified Histone Reader Activity Response To Indole-3-methanol Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Lipid Droplet Fusion Formation Of Translation Preinitiation Complex Positive Regulation Of Triglyceride Catabolic Process Diacylglycerol Catabolic Process Monoacylglycerol Biosynthetic Process Negative Regulation Of Centrosome Duplication Lipid Metabolic Process XY Body Fatty Acid Metabolic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Lateral Element Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gamma-tubulin Ring Complex Apoptotic Signaling Pathway Ubiquitin Protein Ligase Binding DNA Strand Resection Involved In Replication Fork Processing Response To Alcohol	ATP-dependent Polyribonucleotide 5'-hydroxyl-kinase Activity Polynucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polynucleotide 5'-hydroxyl-kinase Activity Phosphatidylserine Decarboxylase Activity TRNA-intron Endonuclease Complex Global Gene Silencing By MRNA Cleavage ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity MRNA Cleavage Factor Complex Cerebellar Cortex Development RISC Complex Assembly Phosphatidylethanolamine Biosynthetic Process Mitochondrial Protein Catabolic Process TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Lipid Droplet Formation Protein Autoprocessing Carboxy-lyase Activity Notch Binding
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