CIDEB and RAMP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CIDEB	RAMP2
Description		cell death inducing DFFA like effector b	receptor activity modifying protein 2
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Cytosol Membrane COPII Vesicle Coat COPI-coated Vesicle Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm	Cytoplasm Lysosome Plasma Membrane Clathrin-coated Pit Cell Surface Membrane Receptor Complex Adrenomedullin Receptor Complex
	Molecular Function	Protein Binding Identical Protein Binding Molecular Adaptor Activity Phosphatidic Acid Binding Lipid Transfer Activity	Adrenomedullin Receptor Activity Protein Binding Coreceptor Activity Adrenomedullin Binding
	Biological Process	Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Lipid Storage Response To Nutrient Levels Very-low-density Lipoprotein Particle Assembly Positive Regulation Of Apoptotic Process COPII-coated Vesicle Cargo Loading Regulation Of Triglyceride Metabolic Process Execution Phase Of Apoptosis Intermembrane Lipid Transfer Lipid Droplet Fusion	Angiogenesis Vasculogenesis Sprouting Angiogenesis Calcium Ion Transport Intracellular Protein Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Regulation Of Blood Pressure Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Protein Transport Receptor Internalization Cellular Response To Hormone Stimulus Adherens Junction Assembly Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Bicellular Tight Junction Assembly Basement Membrane Assembly Protein Localization To Plasma Membrane Vascular Associated Smooth Muscle Cell Development Amylin Receptor 2 Signaling Pathway Adrenomedullin Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Vasculogenesis
Pathways			G alpha (s) signalling events Calcitonin-like ligand receptors High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			Pramlintide
Diseases
GWAS		Anorectal malformation ( 31136621) Height ( 28552196) Parent of origin effect on language impairment (paternal) ( 24571439)	A body shape index ( 34021172) Pulse pressure ( 30224653) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		68 interacting genes: ABHD16A AFG1L APOC1 ARL8B ATP5ME ATP5MJ BCL2L2 CAND2 CIDEA CLCN1 CMPK1 COL10A1 COL8A1 COX7C DFFA DFFB DHRSX DNAJA3 FAM218A FAM47E-STBD1 FKBP8 FOXD4L3 FUNDC2 GCSH GNB3 GPAM H4C7 HAPLN2 HCCS HIGD1C IRX2-DT MEST MICOS10 MPC2 MRPL36 MRPL57 MTERF4 NAALAD2 NDRG4 NFU1 NME4 PBX3 PDHX PGLYRP3 PISD PPIF RAMP2 RHBDD2 ROMO1 RTP5 SAA2 SAA4 SAR1B SCO1 SCO2 SDHAF1 SFXN1 SMARCC1 SPG21 TAOK2 TBX2 TEX44 THBD TIMM17B TMEM14B TPRG1 TSR1 UFSP1	7 interacting genes: CALCA CALCRL CIDEB IAPP LCN2 SLC31A2 VIPR1
Entrez ID		27141	10266
HPRD ID		11981	05516
Ensembl ID		ENSG00000136305	ENSG00000131477
Uniprot IDs		Q9UHD4	O60895
PDB IDs		1D4B	2XVT 3AQE 3AQF 4RWF 6UUN 6V2E 7TYH 7TYX 7TYY
Enriched GO Terms of Interacting Partners?		Mitochondrion Mitochondrial Inner Membrane Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of Apoptotic DNA Fragmentation High-density Lipoprotein Particle Protein Binding Mitochondrion Organization Mitochondrial Membrane Copper Chaperone Activity Disordered Domain Specific Binding T Cell Apoptotic Process Mitochondrial Matrix Organophosphate Biosynthetic Process Cytochrome Complex Assembly Pyruvate Decarboxylation To Acetyl-CoA Activation-induced Cell Death Of T Cells Mitochondrial Respiratory Chain Complex Assembly Lymphocyte Apoptotic Process Import Into The Mitochondrion Negative Regulation Of Execution Phase Of Apoptosis Protein Localization To Mitochondrion	Calcitonin Family Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway Amylin Receptor Signaling Pathway Negative Regulation Of Bone Resorption Negative Regulation Of Bone Remodeling Negative Regulation Of Osteoclast Differentiation Regulation Of Bone Resorption Response To Nerve Growth Factor G Protein-coupled Receptor Signaling Pathway Regulation Of Bone Remodeling Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To Nerve Growth Factor Stimulus Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Myeloid Leukocyte Differentiation G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Metal Ion Transport Receptor Internalization Regulation Of Osteoclast Differentiation Regulation Of Copper Ion Transmembrane Transport Positive Regulation Of Hippocampal Neuron Apoptotic Process Cellular Response To Sucrose Stimulus Regulation Of Tissue Remodeling Regulation Of Monoatomic Ion Transport Calcitonin Receptor Binding Cellular Response To Tumor Necrosis Factor Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Iron Ion Import Across Plasma Membrane Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity Adrenomedullin Binding CGRP Receptor Complex Calcitonin Receptor Activity Hormone Activity Negative Regulation Of Hemopoiesis Positive Regulation Of Apoptotic Process Regulation Of Myeloid Leukocyte Differentiation Receptor Ligand Activity Response To Tumor Necrosis Factor Positive Regulation Of Programmed Cell Death Amylin Receptor 3 Signaling Pathway Siderophore Transport Vasoactive Intestinal Polypeptide Receptor Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Adrenomedullin Receptor Complex Adrenomedullin Receptor Activity
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