CIDEB and CMPK1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CIDEB	CMPK1
Description		cell death inducing DFFA like effector b	cytidine/uridine monophosphate kinase 1
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Cytosol Membrane COPII Vesicle Coat COPI-coated Vesicle Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding Molecular Adaptor Activity Phosphatidic Acid Binding Lipid Transfer Activity	Nucleotide Binding Nucleoside Diphosphate Kinase Activity Uridine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Phosphotransferase Activity, Phosphate Group As Acceptor Nucleobase-containing Compound Kinase Activity UMP Kinase Activity CMP Kinase Activity DCMP Kinase Activity Nucleoside Monophosphate Kinase Activity
	Biological Process	Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Lipid Storage Response To Nutrient Levels Very-low-density Lipoprotein Particle Assembly Positive Regulation Of Apoptotic Process COPII-coated Vesicle Cargo Loading Regulation Of Triglyceride Metabolic Process Execution Phase Of Apoptosis Intermembrane Lipid Transfer Lipid Droplet Fusion	Nucleobase-containing Compound Metabolic Process 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process UMP Biosynthetic Process UDP Biosynthetic Process Pyrimidine Ribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion CDP Biosynthetic Process Nucleoside Monophosphate Phosphorylation Pyrimidine-containing Compound Biosynthetic Process
Pathways			Interconversion of nucleotide di- and triphosphates
Drugs			Gemcitabine Cytidine-5'-Monophosphate Uridine-5'-Diphosphate P1-(adenosine-5'-P5-(uridine-5')pentaphosphate Tetrafluoroaluminate Ion
Diseases
GWAS		Anorectal malformation ( 31136621) Height ( 28552196) Parent of origin effect on language impairment (paternal) ( 24571439)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Corneal curvature ( 24963161) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		68 interacting genes: ABHD16A AFG1L APOC1 ARL8B ATP5ME ATP5MJ BCL2L2 CAND2 CIDEA CLCN1 CMPK1 COL10A1 COL8A1 COX7C DFFA DFFB DHRSX DNAJA3 FAM218A FAM47E-STBD1 FKBP8 FOXD4L3 FUNDC2 GCSH GNB3 GPAM H4C7 HAPLN2 HCCS HIGD1C IRX2-DT MEST MICOS10 MPC2 MRPL36 MRPL57 MTERF4 NAALAD2 NDRG4 NFU1 NME4 PBX3 PDHX PGLYRP3 PISD PPIF RAMP2 RHBDD2 ROMO1 RTP5 SAA2 SAA4 SAR1B SCO1 SCO2 SDHAF1 SFXN1 SMARCC1 SPG21 TAOK2 TBX2 TEX44 THBD TIMM17B TMEM14B TPRG1 TSR1 UFSP1	5 interacting genes: BACE1 CDC42 CIDEB SGTB TMEM132D
Entrez ID		27141	51727
HPRD ID		11981	18258
Ensembl ID		ENSG00000136305	ENSG00000162368
Uniprot IDs		Q9UHD4	A0A494BXC7 P30085
PDB IDs		1D4B	1TEV 7E9V
Enriched GO Terms of Interacting Partners?		Mitochondrion Mitochondrial Inner Membrane Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of Apoptotic DNA Fragmentation High-density Lipoprotein Particle Protein Binding Mitochondrion Organization Mitochondrial Membrane Copper Chaperone Activity Disordered Domain Specific Binding T Cell Apoptotic Process Mitochondrial Matrix Organophosphate Biosynthetic Process Cytochrome Complex Assembly Pyruvate Decarboxylation To Acetyl-CoA Activation-induced Cell Death Of T Cells Mitochondrial Respiratory Chain Complex Assembly Lymphocyte Apoptotic Process Import Into The Mitochondrion Negative Regulation Of Execution Phase Of Apoptosis Protein Localization To Mitochondrion	Leading Edge Membrane Positive Regulation Of Lamellipodium Organization Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Thioesterase Binding Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Nucleus Localization Positive Regulation Of Lamellipodium Assembly Heart Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Pinocytosis Dendritic Cell Migration Apolipoprotein A-I Receptor Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Golgi Localization Establishment Of Monopolar Cell Polarity GTP-dependent Protein Binding Cellular Localization Heart Contraction Endothelin Receptor Signaling Pathway Involved In Heart Process Cardiac Conduction System Development Embryonic Heart Tube Development Establishment Of Epithelial Cell Polarity Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Dendritic Spine Morphogenesis Dendrite Positive Regulation Of Filopodium Assembly Establishment Of Golgi Localization Dendritic Spine Organization Phagocytosis, Engulfment Neuronal Cell Body Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Establishment Or Maintenance Of Monopolar Cell Polarity Neuropilin Signaling Pathway GBD Domain Binding Golgi Transport Complex Storage Vacuole Identical Protein Binding Cell Migration Involved In Heart Development Polarized Epithelial Cell Differentiation Spindle Midzone Supramolecular Fiber Organization Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Nuclear Migration Positive Regulation Of Programmed Cell Death Prepulse Inhibition
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