EID1 and H2BC3

Number of citations of the paper that reports this interaction (PubMedID 11964378)
27

Data Source:
BioGRID (pull down)

		EID1	H2BC3
Description		EP300 interacting inhibitor of differentiation 1	H2B clustered histone 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoplasmic Ribonucleoprotein Granule	Chromosome, Telomeric Region Nucleosome Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	Transcription Corepressor Activity Protein Binding Histone Acetyltransferase Binding	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of DNA-templated Transcription	Nucleosome Assembly
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS
Interacting Genes		19 interacting genes: ARID4A CREBBP EP300 H2AC8 H2BC3 H3C1 H4C1 KAT2A MDM2 NCOA2 NDN NR0B2 PCID2 PSEN2 RB1 SHANK3 TRIM27 UBE3A XRCC6	49 interacting genes: AKT1 ANAPC11 APP BAP1 BARD1 BMI1 BRCA1 CDC20 CDK1 CDK2 CHD4 CREBBP DNMT1 DYRK1A EID1 EP300 ERCC6 FANCD2 HUWE1 KAT2A KAT2B KMT2A KMT2C KMT2D MYB PALB2 PIAS1 PSMD4 PTPN6 RHBDD2 RNF168 RNF2 RNF20 RNF40 RNF8 RPS6KA5 SMYD5 TSPYL5 UBE2A UBR7 UHRF1 USP16 USP2 USP21 USP22 USP36 USP43 USP51 USP7
Entrez ID		23741	3018
HPRD ID		06907	07536
Ensembl ID		ENSG00000255302	ENSG00000276410
Uniprot IDs		Q9Y6B2	P33778
PDB IDs		7SMD	3X1S 3X1U 9C62 9FGQ
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Epigenetic Regulation Of Gene Expression Histone H3K18 Acetyltransferase Activity Protein-containing Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Peptidyl-lysine Acetylation Transcription Coactivator Activity Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Acetyltransferase Activity Histone H3K27 Acetyltransferase Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Structural Constituent Of Chromatin Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process N-terminal Peptidyl-lysine Acetylation Nucleus Peptide Lactyltransferase (CoA-dependent) Activity Nucleoplasm Regulation Of Gene Expression Positive Regulation Of Developmental Process Histone Acetyltransferase Activity Chromosome Regulation Of Hemopoiesis Transcription Regulator Complex Protein Localization To Chromosome Regulation Of Macromolecule Biosynthetic Process Protein Acetylation Rhythmic Process Nucleosome Protein Localization To Chromosome, Centromeric Region Nuclear Receptor Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Cell Development Regulation Of RNA Biosynthetic Process	Chromatin Remodeling Chromatin Organization Post-translational Protein Modification Protein Modification Process Nucleoplasm Protein Metabolic Process Macromolecule Metabolic Process Epigenetic Regulation Of Gene Expression Protein Deubiquitination DNA Repair Chromatin Binding Protein Modification By Small Protein Removal DNA Damage Response Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Transferase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Proteolysis Nucleus DNA Metabolic Process Cellular Response To Stress Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Response To Radiation Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation Cysteine-type Deubiquitinase Activity Negative Regulation Of Biosynthetic Process Protein Ubiquitination Transcription Coactivator Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Double-strand Break Repair Regulation Of DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription
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