PLXNB2 and HMOX2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PLXNB2	HMOX2
Gene Name		plexin B2	heme oxygenase (decycling) 2
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Gene Ontology Annotations	Cellular Component	Intracellular Integral Component Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome	Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Protein Binding Semaphorin Receptor Activity	Heme Oxygenase (decyclizing) Activity Protein Binding Metal Ion Binding
	Biological Process	Neural Tube Closure Regulation Of Protein Phosphorylation Neuroblast Proliferation Brain Development Regulation Of Cell Shape Regulation Of Rho GTPase Activity Positive Regulation Of Axonogenesis Semaphorin-plexin Signaling Pathway Regulation Of Neuron Migration	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Heme Oxidation Cellular Iron Ion Homeostasis Heme Catabolic Process Small Molecule Metabolic Process Transmembrane Transport
Pathways			Iron uptake and transport Metabolism of porphyrins Heme degradation
Drugs			NADH
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ARHGEF11 ARHGEF12 CENPU HMOX2 PFDN1 PTN RND1	32 interactors: A2M APP ATP5B BLOC1S2 CEBPZ COPS6 CSNK2A1 EEF1G EIF3C GIT1 GPRASP1 HAP1 IMMT INPP5K ITFG1 JADE1 KCNMA1 KIAA1377 LRIF1 MED31 NDUFS2 NKRF NR3C1 PLXNB2 RBBP4 SETDB1 SHC1 SKA2 SNX5 SNX7 ZFP28 ZNF746
Entrez ID		23654	3163
HPRD ID		05050	00783
Ensembl ID		ENSG00000196576	ENSG00000103415
Uniprot IDs		O15031	I3L430 P30519
PDB IDs		4E71	2Q32 2QPP 2RGZ
Enriched GO Terms of Interacting Partners?		Axon Guidance Termination Of G-protein Coupled Receptor Signaling Pathway Nervous System Development Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Axonogenesis Multicellular Organismal Development Axon Development Anatomical Structure Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Actin Cytoskeleton Organization Small GTPase Mediated Signal Transduction Neuron Projection Morphogenesis Actin Filament-based Process Heme Oxidation Developmental Process Cell Morphogenesis Involved In Differentiation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neurotrophin TRK Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Neuron Development Positive Regulation Of Rho GTPase Activity Heme Catabolic Process Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway System Development Neuron Remodeling Cell Morphogenesis Regulation Of Rho GTPase Activity Neuron Differentiation Cytoskeleton Organization Cell Projection Organization Regulation Of Rho Protein Signal Transduction Apoptotic Signaling Pathway Locomotion Cell Cycle Positive Regulation Of Ras GTPase Activity Movement Of Cell Or Subcellular Component Organelle Organization CENP-A Containing Nucleosome Assembly Generation Of Neurons Neuron Maturation Neurogenesis Regulation Of Ras GTPase Activity Histone Exchange DNA Replication-independent Nucleosome Assembly	Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Axon Cargo Transport Cellular Macromolecule Biosynthetic Process Organelle Organization Macromolecule Biosynthetic Process RNA Metabolic Process Biosynthetic Process Regulation Of Transcription, DNA-templated Cellular Process Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of ERBB Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Receptor Activity Cell Projection Organization Cellular Nitrogen Compound Metabolic Process Anterograde Axon Cargo Transport Microtubule-based Transport Positive Regulation Of Cellular Biosynthetic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Body Fluid Levels Cytoskeleton-dependent Intracellular Transport Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Glucocorticoid Mediated Signaling Pathway Positive Regulation Of Renal Water Transport Regulation Of Cellular Process Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Cellular Response To CAMP Cellular Homeostasis Regulation Of Mitotic Cell Cycle Platelet Activation
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