PLXNB2 and AIFM2

Number of citations of the paper that reports this interaction (PubMedID 36423520)
50

Data Source:
BioGRID (unspecified method)

		PLXNB2	AIFM2
Description		plexin B2	AIF family member 2
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GO Annotations	Cellular Component	Semaphorin Receptor Complex Plasma Membrane Cell Surface Membrane Extracellular Exosome	Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lipid Droplet Cytosol Plasma Membrane Membrane Mitochondrial Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Semaphorin Receptor Activity Signaling Receptor Activity	DNA Binding Electron-transferring-flavoprotein Dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Flavin Adenine Dinucleotide Binding
	Biological Process	Neural Tube Closure Regulation Of Protein Phosphorylation Cytoplasmic Translation Receptor-mediated Endocytosis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Neuroblast Proliferation Synapse Assembly Brain Development Regulation Of Cell Shape Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Regulation Of Cell Migration Positive Regulation Of Cell Projection Organization Negative Regulation Of Translation In Response To Stress Cellular Response To Stress TRNA Stabilization Regulation Of GTPase Activity Positive Regulation Of Translation Positive Regulation Of Axonogenesis Regulation Of Protein Metabolic Process Semaphorin-plexin Signaling Pathway Excitatory Synapse Assembly Regulation Of Neuron Migration	Ubiquinone Metabolic Process Apoptotic Mitochondrial Changes Respiratory Electron Transport Chain Vitamin K Metabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Ferroptosis Regulation Of Cellular Response To Oxidative Stress Cellular Detoxification
Pathways			TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 30072576) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte count ( 32888494) Nevus count or cutaneous melanoma ( 32341527) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sensorimotor dexterity ( 31596458) Systolic blood pressure ( 30224653)	Post bronchodilator FEV1/FVC ratio ( 26634245) Rheumatoid arthritis ( 30891314)
Interacting Genes		9 interacting genes: AIFM2 ARHGEF11 ARHGEF12 CENPU HDLBP HMOX2 PFDN1 PTN RND1	3 interacting genes: CNPY4 PLXNB2 TRIM21
Entrez ID		23654	84883
HPRD ID		05050	09797
Ensembl ID		ENSG00000196576	ENSG00000042286
Uniprot IDs		O15031	Q9BRQ8
PDB IDs		4E71	8JSC 8WIK 8YO8 8YOQ 8YOX
Enriched GO Terms of Interacting Partners?			Regulation Of Protein Deubiquitination Stress Granule Disassembly Positive Regulation Of Protein Binding Negative Regulation Of Protein Deubiquitination TRNA Stabilization Excitatory Synapse Assembly Negative Regulation Of Translation In Response To Stress Positive Regulation Of Viral Entry Into Host Cell Suppression Of Viral Release By Host Protein K27-linked Ubiquitination Negative Regulation Of Viral Transcription Semaphorin Receptor Activity Semaphorin Receptor Complex Regulation Of Viral Transcription Negative Regulation Of Protein Metabolic Process Regulation Of Viral Entry Into Host Cell Regulation Of Translation In Response To Stress
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