PLXNB2 and ARHGEF11

Number of citations of the paper that reports this interaction (PMID 12123608)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		PLXNB2	ARHGEF11
Gene Name		plexin B2	Rho guanine nucleotide exchange factor (GEF) 11
Image
Gene Ontology Annotations	Cellular Component	Intracellular Integral Component Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome	Intracellular Cytoplasm Cytosol Membrane
	Molecular Function	Protein Binding Semaphorin Receptor Activity	G-protein Coupled Receptor Binding Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Neural Tube Closure Regulation Of Protein Phosphorylation Neuroblast Proliferation Brain Development Regulation Of Cell Shape Regulation Of Rho GTPase Activity Positive Regulation Of Axonogenesis Semaphorin-plexin Signaling Pathway Regulation Of Neuron Migration	Cytokinesis Regulation Of Cell Growth Movement Of Cell Or Subcellular Component Striated Muscle Contraction G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Axon Guidance Establishment Of Cell Polarity Actin Cytoskeleton Organization Positive Regulation Of Rho GTPase Activity Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways			Signaling by GPCR Signalling by NGF Axon guidance Semaphorin interactions Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ARHGEF11 ARHGEF12 CENPU HMOX2 PFDN1 PTN RND1	13 interactors: ABCA1 CDC42 GNA12 GNA13 LPAR1 LPAR2 MAP1A MAP1B PLXNB1 PLXNB2 PLXNB3 RHOA SLC1A6
Entrez ID		23654	9826
HPRD ID		05050	09302
Ensembl ID		ENSG00000196576	ENSG00000132694
Uniprot IDs		O15031	F8W8P9 O15085
PDB IDs		4E71	1HTJ 1XCG 2DLS 3KZ1 3T06
Enriched GO Terms of Interacting Partners?		Axon Guidance Termination Of G-protein Coupled Receptor Signaling Pathway Nervous System Development Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Axonogenesis Multicellular Organismal Development Axon Development Anatomical Structure Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Actin Cytoskeleton Organization Small GTPase Mediated Signal Transduction Neuron Projection Morphogenesis Actin Filament-based Process Heme Oxidation Developmental Process Cell Morphogenesis Involved In Differentiation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neurotrophin TRK Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Neuron Development Positive Regulation Of Rho GTPase Activity Heme Catabolic Process Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway System Development Neuron Remodeling Cell Morphogenesis Regulation Of Rho GTPase Activity Neuron Differentiation Cytoskeleton Organization Cell Projection Organization Regulation Of Rho Protein Signal Transduction Apoptotic Signaling Pathway Locomotion Cell Cycle Positive Regulation Of Ras GTPase Activity Movement Of Cell Or Subcellular Component Organelle Organization CENP-A Containing Nucleosome Assembly Generation Of Neurons Neuron Maturation Neurogenesis Regulation Of Ras GTPase Activity Histone Exchange DNA Replication-independent Nucleosome Assembly	Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Positive Regulation Of Cell Projection Organization Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Axonogenesis Positive Regulation Of Neuron Projection Development Regulation Of Cellular Component Organization Positive Regulation Of Cell Development Cell Surface Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Neuron Differentiation Regulation Of Rho Protein Signal Transduction Regulation Of Locomotion Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Movement Regulation Of Neuron Projection Development Regulation Of Axonogenesis Regulation Of Cell Shape Semaphorin-plexin Signaling Pathway Positive Regulation Of Neurogenesis Regulation Of Cell Development Positive Regulation Of Cell Differentiation Apolipoprotein A-I-mediated Signaling Pathway Rho Protein Signal Transduction Axonogenesis Generation Of Neurons Signaling Regulation Of Cell Differentiation Regulation Of Neuron Differentiation Cell Communication Axon Development Positive Regulation Of Phospholipase Activity Anatomical Structure Morphogenesis Neurogenesis Cell Morphogenesis Involved In Neuron Differentiation Cell Differentiation Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Neuron Projection Morphogenesis Cell Projection Organization Regulation Of Ras Protein Signal Transduction Regulation Of Neurogenesis Regulation Of Signal Transduction Cell Morphogenesis Involved In Differentiation Ossification Involved In Bone Maturation Signal Transduction Positive Regulation Of Intracellular Signal Transduction Bone Maturation
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