PLXNB2 and ARHGEF12

Number of citations of the paper that reports this interaction (PMID 12183458)
53

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid)

		PLXNB2	ARHGEF12
Gene Name		plexin B2	Rho guanine nucleotide exchange factor (GEF) 12
Image
Gene Ontology Annotations	Cellular Component	Intracellular Integral Component Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome	Cytoplasm Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Semaphorin Receptor Activity	G-protein Coupled Receptor Binding Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Neural Tube Closure Regulation Of Protein Phosphorylation Neuroblast Proliferation Brain Development Regulation Of Cell Shape Regulation Of Rho GTPase Activity Positive Regulation Of Axonogenesis Semaphorin-plexin Signaling Pathway Regulation Of Neuron Migration	G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways			Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE Semaphorin interactions p75 NTR receptor-mediated signalling Rho GTPase cycle GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ARHGEF11 ARHGEF12 CENPU HMOX2 PFDN1 PTN RND1	13 interactors: ABCA1 CD44 CUL3 GNA12 GNA13 IGF1R KLHL20 LPAR1 LPAR2 PLXNB1 PLXNB2 RHOA TEC
Entrez ID		23654	23365
HPRD ID		05050	09207
Ensembl ID		ENSG00000196576	ENSG00000196914
Uniprot IDs		O15031	B4E2K6 E9PMR6 Q9NZN5
PDB IDs		4E71	1TXD 1X86 2OMJ 2OS6
Enriched GO Terms of Interacting Partners?		Axon Guidance Termination Of G-protein Coupled Receptor Signaling Pathway Nervous System Development Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Axonogenesis Multicellular Organismal Development Axon Development Anatomical Structure Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Actin Cytoskeleton Organization Small GTPase Mediated Signal Transduction Neuron Projection Morphogenesis Actin Filament-based Process Heme Oxidation Developmental Process Cell Morphogenesis Involved In Differentiation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neurotrophin TRK Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Neuron Development Positive Regulation Of Rho GTPase Activity Heme Catabolic Process Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway System Development Neuron Remodeling Cell Morphogenesis Regulation Of Rho GTPase Activity Neuron Differentiation Cytoskeleton Organization Cell Projection Organization Regulation Of Rho Protein Signal Transduction Apoptotic Signaling Pathway Locomotion Cell Cycle Positive Regulation Of Ras GTPase Activity Movement Of Cell Or Subcellular Component Organelle Organization CENP-A Containing Nucleosome Assembly Generation Of Neurons Neuron Maturation Neurogenesis Regulation Of Ras GTPase Activity Histone Exchange DNA Replication-independent Nucleosome Assembly	Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Signal Transduction Signal Transduction Regulation Of Signaling Regulation Of Cell Migration Signaling Cell Communication Regulation Of Cell Motility Anatomical Structure Morphogenesis Tissue Morphogenesis Regulation Of Ras Protein Signal Transduction Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Stimulus Positive Regulation Of Cytokinesis Regulation Of Cell Shape Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Regulation Of Cell Morphogenesis Apolipoprotein A-I-mediated Signaling Pathway Regulation Of Cytokinesis Rho Protein Signal Transduction Regulation Of Phosphorus Metabolic Process Morphogenesis Of An Epithelium Positive Regulation Of Neuron Projection Development Regulation Of Catalytic Activity Positive Regulation Of Axonogenesis Positive Regulation Of Phospholipase Activity Regulation Of Protein Phosphorylation Cell Differentiation Positive Regulation Of Metabolic Process Wound Healing Positive Regulation Of Cell Projection Organization Positive Regulation Of Cell Cycle Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Multicellular Organismal Development Intracellular Signal Transduction Anatomical Structure Development Response To Wounding Positive Regulation Of Neuron Differentiation Cell Morphogenesis Involved In Differentiation Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Ossification Involved In Bone Maturation
Tagcloud ?			11q23 adulthood beginning bronchi catalyzing colocalization embryogenesis exchange gastrulation gdp gtp gtpases guanine homologue incompletely intestine larg melanogaster mll morphogenesis neurite observe originally outgrowth physiologic rho rhoa undetectable vasculature
Tagcloud (Difference) ?			11q23 adulthood beginning bronchi catalyzing colocalization embryogenesis exchange gastrulation gdp gtp gtpases guanine homologue incompletely intestine larg melanogaster mll morphogenesis neurite observe originally outgrowth physiologic rho rhoa undetectable vasculature
Tagcloud (Intersection) ?