NMNAT1 and MSX1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		NMNAT1	MSX1
Name		nicotinamide nucleotide adenylyltransferase 1	msh homeobox 1
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Body	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nuclear Periphery
	Molecular Function	Nucleotide Binding Nicotinamide-nucleotide Adenylyltransferase Activity Catalytic Activity Nicotinate-nucleotide Adenylyltransferase Activity Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Identical Protein Binding Protein ADP-ribosyltransferase-substrate Adaptor Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Purine Nucleotide Metabolic Process Nicotinamide Metabolic Process Nucleotide Biosynthetic Process NAD+ Biosynthetic Process Response To Wounding Pyridine Nucleotide Biosynthetic Process NAD+ Biosynthetic Process Via The Salvage Pathway Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Negative Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of Adipose Tissue Development Positive Regulation Of Adipose Tissue Development ATP Generation From Poly-ADP-D-ribose	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis In Utero Embryonic Development Epithelial To Mesenchymal Transition Heart Morphogenesis Cardiac Conduction System Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Heart Development Muscle Organ Development Negative Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Anterior/posterior Pattern Specification Mesenchymal Cell Proliferation Negative Regulation Of Gene Expression Pituitary Gland Development Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Cell Growth Embryonic Limb Morphogenesis BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Forebrain Development Midbrain Development Protein Localization To Nucleus Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Nail Plate Morphogenesis Middle Ear Morphogenesis Odontogenesis Of Dentin-containing Tooth Odontogenesis Regulation Of Odontogenesis Positive Regulation Of Odontogenesis Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Nose Development Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Morphogenesis Inner Ear Development Stem Cell Differentiation Protein Stabilization Negative Regulation Of Striated Muscle Cell Differentiation Cartilage Development Roof Of Mouth Development Face Morphogenesis Bone Morphogenesis Cartilage Morphogenesis Mammary Gland Epithelium Development Cell Surface Receptor Signaling Pathway Involved In Heart Development Cellular Response To Nicotine Activation Of Meiosis Mesenchymal Cell Apoptotic Process Negative Regulation Of Odontoblast Differentiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Mesenchymal Cell Apoptotic Process
Pathways		Nicotinate metabolism	Specification of the neural plate border
Drugs		Nicotinamide Mononucleotide Deamido-Nad+	None
Diseases		None	Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Tooth and nail syndrome; Witkop syndrome Tooth agenesis; Hypodontia
GWAS		Resting heart rate ( 27798624 )	Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Breast cancer and/or colorectal cancer ( 29698419 ) Congenital heart disease ( 23708191 ) Electrocardiographic conduction measures ( 19389651 ) Nonsyndromic cleft lip with cleft palate ( 28232668 )
Novel Interactors		1 novel interactors: PABPC4	None recorded
Interacting Genes		19 interacting genes: APP BANP CCNC FLOT2 GORASP2 KPNA1 KPNA2 KPNA3 KPNA5 KPNA6 MSX1 NEK3 NFATC2IP NTRK2 PICK1 RNF4 SIK1 SIRT1 TDO2	25 interacting genes: CREBBP DLX2 DLX5 HOXC8 ING4 LHX2 MED19 MSX2 NMNAT1 PAX3 PAX9 PIAS1 POU2F1 RBPMS RGS7 SP1 SUMO1 SUMO2 TAF1 TBP TLE1 TLE2 TLE4 TLE5 TP53
Entrez ID		64802	4487
HPRD ID		16369	00866
Ensembl ID		ENSG00000173614	ENSG00000163132
Uniprot IDs		B1AN62 Q9HAN9	P28360
PDB IDs		1GZU 1KKU 1KQN 1KQO 1KR2 8QE8	Not available
GO Terms Enriched among Interactors		NLS-dependent Protein Nuclear Import Complex Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding NLS-bearing Protein Import Into Nucleus Viral Penetration Into Host Nucleus Protein Localization To Nucleus Intracellular Transport Of Virus Host Cell Protein Import Into Nucleus Import Into Nucleus Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Nuclear Transport Nucleocytoplasmic Transport Negative Regulation Of Triglyceride Biosynthetic Process Cellular Localization Intracellular Protein Transport Regulation Of Amyloid Precursor Protein Catabolic Process Intracellular Transport Establishment Of Protein Localization To Organelle Protein Localization To Organelle Negative Regulation Of Triglyceride Metabolic Process Establishment Of Localization In Cell Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Viral Life Cycle Establishment Of Protein Localization Regulation Of Anoikis Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Receptor Internalization Intracellular Protein Localization Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Cellular Response To Nerve Growth Factor Stimulus Protein Transport Viral Process Regulation Of Muscle Cell Differentiation	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Nucleoplasm Transcription Regulator Complex Transcription Cis-regulatory Region Binding Transcription Corepressor Activity Negative Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription Initiation By RNA Polymerase II RNA Polymerase II Core Promoter Sequence-specific DNA Binding Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II DNA-binding Transcription Factor Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Initiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Presynaptic Cytosol Postsynaptic Cytosol