NMNAT1 and FLOT2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NMNAT1	FLOT2
Gene Name		nicotinamide nucleotide adenylyltransferase 1	flotillin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Acrosomal Membrane Endosome Plasma Membrane Caveola Focal Adhesion Membrane Flotillin Complex Endocytic Vesicle Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Nicotinamide-nucleotide Adenylyltransferase Activity Nicotinate-nucleotide Adenylyltransferase Activity Protein Binding ATP Binding	Protease Binding Protein Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process NAD Biosynthetic Process NAD Metabolic Process Small Molecule Metabolic Process	Cell Adhesion Epidermis Development Negative Regulation Of Gene Expression Protein Stabilization Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Amyloid Precursor Protein Catabolic Process
Pathways		Metabolism of vitamins and cofactors Defective GIF causes intrinsic factor deficiency Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Nicotinate metabolism Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism
Drugs		Nicotinamide-Adenine-Dinucleotide Nicotinamide Mononucleotide Deamido-Nad+
Diseases
GWAS
Protein-Protein Interactions		10 interactors: APP CCNC FLOT2 KPNA2 MSX1 NEK3 NTRK2 SIK1 SIRT1 TDO2	8 interactors: APP CAV1 CAV2 DXO FLOT1 FYN NMNAT1 SPATA24
Entrez ID		64802	2319
HPRD ID		16369	00580
Ensembl ID		ENSG00000173614	ENSG00000132589
Uniprot IDs		B1AN62 Q9HAN9	J3QLD9 Q14254 Q6FG43 Q9BTI6
PDB IDs		1GZU 1KKU 1KQN 1KQO 1KR2
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Regulation Of Protein Stability Response To Radiation Regulation Of Anoikis Posttranscriptional Regulation Of Gene Expression Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Cellular Ketone Metabolic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Lipid Biosynthetic Process Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Gene Expression Neuromuscular Junction Development Rhythmic Process Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Response To Light Stimulus Cardiovascular System Development Positive Regulation Of Response To DNA Damage Stimulus Establishment Of Chromatin Silencing Negative Regulation Of Cellular Response To Testosterone Stimulus Negative Regulation Of Prostaglandin Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To Organic Substance Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Stabilization Regulation Of Protein Phosphorylation Forebrain Development Response To Abiotic Stimulus Feeding Behavior Regulation Of Striated Muscle Cell Differentiation Cellular Response To Tumor Necrosis Factor Negative Regulation Of Triglyceride Biosynthetic Process Synaptic Growth At Neuromuscular Junction Behavioral Response To Starvation Tryptophan Catabolic Process To Acetyl-CoA Regulation Of Glucose Metabolic Process Regulation Of Gene Expression Muscle Structure Development Regulation Of Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Kinase B Signaling Negative Regulation Of CREB Transcription Factor Activity Maintenance Of Chromatin Silencing Negative Regulation Of Helicase Activity Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Chromatin Silencing Collateral Sprouting In Absence Of Injury	Caveola Assembly Membrane Raft Assembly Membrane Raft Organization Membrane Assembly Membrane Biogenesis Plasma Membrane Organization Negative Regulation Of Endothelial Cell Proliferation Regulation Of Protein Tyrosine Kinase Activity Cell Differentiation T Cell Costimulation Blood Coagulation Hemostasis Endomembrane System Organization Regulation Of Endothelial Cell Proliferation Regulation Of Membrane Repolarization During Action Potential Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Water-soluble Vitamin Metabolic Process Feeding Behavior Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Axonogenesis Vitamin Metabolic Process Synaptic Growth At Neuromuscular Junction Nitric Oxide Homeostasis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Body Fluid Levels Vesicle-mediated Transport Negative Regulation Of Epithelial Cell Proliferation Wound Healing Dendrite Development Regulation Of Signal Transduction Skeletal Muscle Tissue Development Learning Neuron Projection Morphogenesis Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Positive Regulation Of Dopamine Receptor Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Inward Rectifier Potassium Channel Activity Positive Regulation Of Peptidase Activity Regulation Of Protein Binding Skeletal Muscle Organ Development Endocytosis Protein Localization To Plasma Membrane Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organismal Development Response To Wounding Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Pinocytosis
Tagcloud ?		adenylyltransferase amaurosis atrophy autosomal caucasian cone crd dystrophies dystrophy e257k encompassed harbors heterozygous inherited insignificant lca leber macular modifier nicotinamide persons pigmentosa recessive retinitis rod rp sanger truncating variants	adjacent aimed archived biomarker biopsies blotting breast classification clinicopathological duration embedded erbb2 flotillin histological ihc immunohistochemistry implicated multivariate noncancerous paired paraffin prognostic quantified real shorter significance statistical tissues upregulated
Tagcloud (Difference) ?		adenylyltransferase amaurosis atrophy autosomal caucasian cone crd dystrophies dystrophy e257k encompassed harbors heterozygous inherited insignificant lca leber macular modifier nicotinamide persons pigmentosa recessive retinitis rod rp sanger truncating variants	adjacent aimed archived biomarker biopsies blotting breast classification clinicopathological duration embedded erbb2 flotillin histological ihc immunohistochemistry implicated multivariate noncancerous paired paraffin prognostic quantified real shorter significance statistical tissues upregulated
Tagcloud (Intersection) ?