NOP2 and RAB2B

Number of citations: 84 (PubMedID 34133714)
Data Source: BioGRID (two hybrid)

		NOP2	RAB2B
Name		NOP2 nucleolar protein	RAB2B, member RAS oncogene family
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Golgi Membrane Autophagosome Membrane Acrosomal Vesicle Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Methyltransferase Activity RNA Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity RRNA (cytosine-C5-)-methyltransferase Activity Transferase Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Ribosomal Large Subunit Assembly Maturation Of LSU-rRNA RNA Methylation RRNA Processing RNA Processing Positive Regulation Of Cell Population Proliferation Methylation Ribosome Biogenesis Ribosomal Large Subunit Biogenesis RRNA Base Methylation Regulation Of Signal Transduction By P53 Class Mediator	Golgi Organization Protein Transport Vesicle-mediated Transport Macroautophagy Positive Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of Exocytosis Defense Response To Virus
Pathways		rRNA modification in the nucleus and cytosol TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	RAB geranylgeranylation
GWAS		No GWAS studies recorded	Height ( 31562340 )
Novel Interactors		None recorded	1 novel interactors: SLC25A21
Interacting Genes		16 interacting genes: CDC42 CDCA7L CEBPA CEP70 KPNA6 MCRS1 MT1F NPM1 PTPRJ PVT1 RAB2B RNF10 SUMO2 UBE2I USP7 VPS52	20 interacting genes: ADAMTSL4 APP BLZF1 CRK FAM114A1 FAM114A2 GARIN4 GARIN6 GOLGA2 ICA1 MEOX2 NOP2 SGSM2 SMAD1 SMAD4 SRSF11 STAMBPL1 TBX19 TXNDC11 VRTN
Entrez ID		4839	84932
HPRD ID		01244	06312
Ensembl ID		ENSG00000111641	ENSG00000129472
Uniprot IDs		P46087	B4DUD4 Q8WUD1
PDB IDs		8FKT 8FKU 8FKV 8FKW 8FKX 8FKY	2A5J
GO Terms Enriched among Interactors		Macrophage Differentiation Positive Regulation Of Protein Localization To Nucleolus Regulation Of Protein Localization To Nucleolus Myeloid Cell Differentiation SUMO Transferase Activity PML Body Leukocyte Differentiation Mononuclear Cell Differentiation Myeloid Leukocyte Differentiation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nuclear Body Presynaptic Cytosol Postsynaptic Cytosol Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of RNA Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Embryonic Ectodermal Digestive Tract Development SUMO Conjugating Enzyme Activity Positive Regulation Of Macromolecule Biosynthetic Process Protein Sumoylation Glutamatergic Synapse Postsynapse Regulation Of Vesicle-mediated Transport Nucleolus Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Nuclear Transport Nucleocytoplasmic Transport GBD Domain Binding Storage Vacuole Response To Vitamin B2 C/EBP Complex Regulation Of Endoribonuclease Activity Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Regulation Of Growth Negative Regulation Of Protein Kinase Activity	Heteromeric SMAD Protein Complex Embryonic Pattern Specification SMAD Protein Complex Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Response To Yeast I-SMAD Binding Cardiac Conduction System Development Cellular Response To Growth Factor Stimulus Golgi Organization SMAD Protein Signal Transduction