NOP2 and PVT1

Number of citations: 0 (PubMedID 36348010)
Data Source: BioGRID (unspecified method)

		NOP2	PVT1
Name		NOP2 nucleolar protein	Pvt1 oncogene
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	None
	Molecular Function	RNA Binding Protein Binding Methyltransferase Activity RNA Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity RRNA (cytosine-C5-)-methyltransferase Activity Transferase Activity	None
	Biological Process	Ribosomal Large Subunit Assembly Maturation Of LSU-rRNA RNA Methylation RRNA Processing RNA Processing Positive Regulation Of Cell Population Proliferation Methylation Ribosome Biogenesis Ribosomal Large Subunit Biogenesis RRNA Base Methylation Regulation Of Signal Transduction By P53 Class Mediator	None
Pathways		rRNA modification in the nucleus and cytosol TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	None
GWAS		No GWAS studies recorded	Allergic sensitization ( 30013184 23817571 ) Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Appendicular lean mass ( 33097823 ) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199 ) Basophil count ( 32888494 ) Bell's palsy ( 33602968 ) Celiac disease and Rheumatoid arthritis ( 26546613 ) Crohn's disease ( 32581322 ) Diffuse large B cell lymphoma ( 25261932 ) End-stage renal disease ( 17395743 ) Eosinophil count ( 32888494 27863252 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 32888494 27863252 ) Follicular lymphoma ( 25279986 ) Graft survival time in renal transplantation (donor effect) x APOL1 genotype interaction ( 32080893 ) Hematocrit ( 32888494 27863252 ) Hemoglobin ( 32888494 ) Hemoglobin concentration ( 27863252 ) Hodgkin's lymphoma ( 21037568 ) Immunoglobulin A ( 20694011 ) Lung cancer ( 28604730 ) Lymphocyte count ( 27863252 32888494 ) Mean corpuscular hemoglobin ( 32888494 27863252 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Mean corpuscular volume ( 32888494 27863252 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (adrenergics, inhalants) ( 31015401 ) Medication use (thyroid preparations) ( 31015401 ) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736 ) Multiple sclerosis ( 21833088 31604244 ) Neutrophil count ( 32888494 ) Neutrophil percentage of granulocytes ( 27863252 ) Neutrophil percentage of white cells ( 32888494 ) Orofacial clefts ( 19270707 ) Pancreatic cancer ( 25086665 ) Platelet count ( 32888494 ) Plateletcrit ( 27863252 32888494 ) Psychosis (atypical) ( 24132900 ) Renal cell carcinoma ( 24220699 ) Response to methotrexate in juvenile idiopathic arthritis ( 24709693 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Rheumatoid arthritis ( 24390342 30423114 ) Seasonality ( 25562672 ) Selective IgA deficiency ( 27723758 ) Sum eosinophil basophil counts ( 27863252 ) Systemic lupus erythematosus ( 28714469 ) Type 2 diabetes ( 30297969 ) Urinary bladder cancer ( 24861552 ) Urinary calcium excretion ( 31993563 ) Waist-hip ratio ( 28552196 ) White blood cell count ( 27863252 32888494 )
Interacting Genes		16 interacting genes: CDC42 CDCA7L CEBPA CEP70 KPNA6 MCRS1 MT1F NPM1 PTPRJ PVT1 RAB2B RNF10 SUMO2 UBE2I USP7 VPS52	7 interacting genes: ERG HSP90B1 KRT9 NOP2 POTEKP RBM25 RPS16
Entrez ID		4839	5820
HPRD ID		01244	Not available
Ensembl ID		ENSG00000111641	ENSG00000249859
Uniprot IDs		P46087	Not available
PDB IDs		8FKT 8FKU 8FKV 8FKW 8FKX 8FKY	Not available
GO Terms Enriched among Interactors		Macrophage Differentiation Positive Regulation Of Protein Localization To Nucleolus Regulation Of Protein Localization To Nucleolus Myeloid Cell Differentiation SUMO Transferase Activity PML Body Leukocyte Differentiation Mononuclear Cell Differentiation Myeloid Leukocyte Differentiation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nuclear Body Presynaptic Cytosol Postsynaptic Cytosol Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of RNA Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Embryonic Ectodermal Digestive Tract Development SUMO Conjugating Enzyme Activity Positive Regulation Of Macromolecule Biosynthetic Process Protein Sumoylation Glutamatergic Synapse Postsynapse Regulation Of Vesicle-mediated Transport Nucleolus Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Nuclear Transport Nucleocytoplasmic Transport GBD Domain Binding Storage Vacuole Response To Vitamin B2 C/EBP Complex Regulation Of Endoribonuclease Activity Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Regulation Of Growth Negative Regulation Of Protein Kinase Activity	None