MKRN2 and UBE2K

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		MKRN2	UBE2K
Gene Name		makorin ring finger protein 2	ubiquitin-conjugating enzyme E2K
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular	Nucleus Cytoplasm Actin Cytoskeleton Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Ligase Activity Poly(A) RNA Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Biological_process Protein Ubiquitination	Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K48-linked Ubiquitination
Pathways			RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Antigen processing: Ubiquitination & Proteasome degradation Negative regulators of RIG-I/MDA5 signaling Class I MHC mediated antigen processing & presentation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: C1orf109 GNB2L1 NDN RBCK1 UBE2D1 UBE2D4 UBE2K	68 interactors: AMFR ANAPC11 BFAR BIRC7 BIRC8 BRCA1 CASP12 CBLC CDC6 DDI1 DDX58 DIABLO DTX3 DTX3L DZIP3 FZR1 HTT ITCH ITSN1 LRSAM1 MARCH3 MARCH7 MDM2 MID1 MIPOL1 MKRN2 MKRN3 NEDD4L NEDD8 NFKB1 NUB1 PIAS4 PRPF40A PRRG4 RBCK1 REL RING1 RNF111 RNF114 RNF125 RNF138 RNF144A RNF167 RNF2 RNF32 RNF4 RNF41 RNF5 SIAH1 TP53 TRAF7 TRAIP TRIM2 TRIM27 TRIM3 TRIM31 TRIM34 TRIM35 TRIM39 TRIM43 TRIM5 UBA1 UBC UBE2I UBOX5 UHRF2 WWP2 ZDHHC17
Entrez ID		23609	3093
HPRD ID		09761	04165
Ensembl ID		ENSG00000075975	ENSG00000078140
Uniprot IDs		B4DPR4 Q9H000	B4DIZ2 P61086
PDB IDs			1YLA 2O25 3E46 3F92 3K9O 3K9P
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein K48-linked Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of CAMP Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Protein Linear Polyubiquitination Cellular Macromolecule Catabolic Process Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Apoptotic Signaling Pathway Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination Positive Regulation Of Protein Catabolic Process Negative Regulation Of Oxidative Stress-induced Neuron Death Regulation Of Cell Division Protein K6-linked Ubiquitination Positive Regulation Of Proteolysis Positive Regulation Of Protein Homooligomerization Positive Regulation Of Gastrulation Negative Regulation Of Transferase Activity Negative Regulation Of Hydrogen Peroxide-induced Cell Death Positive Regulation Of Mitochondrial Depolarization Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Phagocytosis Protein Metabolic Process Negative Regulation Of Necroptotic Process Respiratory System Process Negative Regulation Of Necrotic Cell Death Cellular Protein Modification Process Regulation Of Necroptotic Process Negative Regulation Of Protein Tyrosine Kinase Activity Proteolysis Regulation Of Mitochondrial Depolarization Positive Regulation Of Protein Oligomerization Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Import Into Nucleus Protein K11-linked Ubiquitination	Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Proteolysis Proteasomal Protein Catabolic Process Apoptotic Process Programmed Cell Death Cell Death Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Death Protein K63-linked Ubiquitination Negative Regulation Of Cellular Metabolic Process Metabolic Process Regulation Of Apoptotic Process Catabolic Process Protein Autoubiquitination Positive Regulation Of Signal Transduction Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of RNA Biosynthetic Process Viral Process Neuron Apoptotic Process Response To Stress Negative Regulation Of Biosynthetic Process Regulation Of Viral Release From Host Cell Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Neuron Death Regulation Of Signaling Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle
Tagcloud ?			antiviral attributes breadth chains conjugase cooperated demands e3 elicits elusive epsilon hundreds identifies ifn ikkepsilon interacted interferons isg isgs k48 ligase polyubiquitin stat1 trim trim6 tripartite ubiquitin unanchored unrecognized
Tagcloud (Difference) ?			antiviral attributes breadth chains conjugase cooperated demands e3 elicits elusive epsilon hundreds identifies ifn ikkepsilon interacted interferons isg isgs k48 ligase polyubiquitin stat1 trim trim6 tripartite ubiquitin unanchored unrecognized
Tagcloud (Intersection) ?