MKRN1 and DUSP23

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		MKRN1	DUSP23
Name		makorin ring finger protein 1	dual specificity phosphatase 23
Structure		No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity
	Biological Process	Protein Polyubiquitination Protein Ubiquitination	Dephosphorylation Cilium Assembly
Pathways		AKT phosphorylates targets in the cytosol Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation	None
Drugs		None	4-Nitrophenyl Phosphate
GWAS		Age at first birth ( 34211149 ) Age at first sexual intercourse ( 34211149 ) General risk tolerance (MTAG) ( 30643258 ) Gut microbiota relative abundance (unassigned genus belonging to family Lachnospiraceae) ( 33208821 ) Immature fraction of reticulocytes ( 32888494 ) Number of sexual partners ( 30643258 )	Bone mineral density (Ward's triangle area) ( 27397699 ) C-reactive protein ( 22939635 ) Interstitial lung disease ( 21787189 )
Interacting Genes		28 interacting genes: APC ASH2L BYSL CDKN2A CSNK1G1 DAXX DUSP23 EXOSC8 FADD FAM161A KCNH1 MAP1LC3B MTURN NAA10 OTUB2 PABPC1 RAD23A RAD23B RPS10 SDCBP SLC13A1 TSC2 UBASH3A UBE2D1 UBE2D3 UBE2D4 UBE2W YOD1	32 interacting genes: ASB13 ASB6 BANF2 CCDC186 CEP126 DBI DBN1 DDIT4L DNMT3B EDRF1 EED EXOSC8 GCM1 KAT5 KBTBD7 MKRN1 MRNIP MRPL20 MTFR1 NIF3L1 PRDX4 PSMB8 PSME2 RPL8 RUFY2 SHC1 SMPD1 TCF4 TMOD3 TUBA1A UBA3 ZNF746
Entrez ID		23608	54935
HPRD ID		09673	07908
Ensembl ID		ENSG00000133606	ENSG00000158716
Uniprot IDs		Q9UHC7	A0A140VJI5 Q9BVJ7
PDB IDs		Not available	2IMG 4ERC
GO Terms Enriched among Interactors		Ubiquitin Conjugating Enzyme Activity Macromolecule Catabolic Process Cytosol Nucleus Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Response To Stress Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Protein Catabolic Process Cytoplasm Proteolysis Protein Polyubiquitination Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleoplasm Ubiquitin Protein Ligase Binding Negative Regulation Of Cyclin-dependent Protein Kinase Activity Protein K11-linked Deubiquitination TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Post-translational Protein Modification TOR Signaling Proteasome Binding Negative Regulation Of TOR Signaling Regulation Of Protein Metabolic Process Regulation Of TORC1 Signaling Ubiquitin Binding Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Cellular Response To Nutrient Levels Protein K6-linked Ubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Topologically Incorrect Protein Positive Regulation Of Viral Genome Replication Macromolecule Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Serine/threonine Kinase Activity DNA Damage Response Ligase Inhibitor Activity Cyclic Nucleotide Binding Interleukin-5 Receptor Complex Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Polyubiquitin Modification-dependent Protein Binding	None