MKRN1 and EXOSC8

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		MKRN1	EXOSC8
Gene Name		makorin ring finger protein 1	exosome component 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component	Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Poly(A) RNA Binding	Exoribonuclease Activity Protein Binding AU-rich Element Binding
	Biological Process	Protein Polyubiquitination	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Biological_process Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CSNK1G1 DUSP23 EXOSC8 FADD MAP1LC3B UBE2D3 UBE2W	42 interactors: AEN ATF2 COL23A1 COX5A CRMP1 CWC22 DIS3 DUSP23 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FAM90A1 FHOD1 FOXN3 FRG1 LSM1 LSM7 MKRN1 MORN4 MPP6 OTUD4 RASSF1 REL RPP14 SKIV2L2 SNRPC TCEA2 TFAP4 TXNDC17 TXNDC9 UBC UPF2 USP6 XRN1 XRN2 ZFP36
Entrez ID		23608	11340
HPRD ID		09673	09351
Ensembl ID		ENSG00000133606	ENSG00000120699
Uniprot IDs		Q9UHC7	Q96B26
PDB IDs			2NN6
Enriched GO Terms of Interacting Partners?		Protein K11-linked Ubiquitination Protein Monoubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Toll-like Receptor Signaling Pathway Motor Neuron Apoptotic Process Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response TRAIL-activated Apoptotic Signaling Pathway Catabolic Process Protein Polyubiquitination Positive Regulation Of Innate Immune Response Cellular Macromolecule Catabolic Process Necroptotic Signaling Pathway Positive Regulation Of Cellular Extravasation Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Macrophage Differentiation Negative Regulation Of Activation-induced Cell Death Of T Cells Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Activation-induced Cell Death Of T Cells Misfolded Or Incompletely Synthesized Protein Catabolic Process Cellular Response To Misfolded Protein Negative Regulation Of Necroptotic Process Response To Misfolded Protein Cellular Response To Nitrogen Starvation Lymph Node Development Negative Regulation Of Necrotic Cell Death Regulation Of Necroptotic Process Positive Regulation Of T Cell Migration Regulation Of T Cell Migration Nucleophagy Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Activated T Cell Proliferation Regulation Of Necrotic Cell Death Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Stress Immune Response-regulating Signaling Pathway Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Cellular Protein Modification Process Negative Regulation Of T Cell Apoptotic Process Mitochondrion Degradation	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Metabolic Process RRNA Metabolic Process RRNA Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Ribosome Biogenesis Aromatic Compound Catabolic Process Nuclear MRNA Surveillance Ribonucleoprotein Complex Biogenesis RNA Metabolic Process Cellular Macromolecule Catabolic Process NcRNA Metabolic Process RNA Surveillance RNA Phosphodiester Bond Hydrolysis RRNA Catabolic Process Nucleobase-containing Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Maturation Of 5.8S RRNA Gene Expression Cellular Nitrogen Compound Metabolic Process Catabolic Process Nitrogen Compound Metabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process DNA Deamination Histone MRNA Catabolic Process RNA Processing Cellular Metabolic Process Histone MRNA Metabolic Process MRNA Processing Intracellular MRNA Localization Metabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' DNA Modification Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA Splicing SnoRNA Metabolic Process RNA Splicing, Via Transesterification Reactions
Tagcloud ?		apathogenic aspects cap circovirus gc1qr genotypes hsp40 hybrid immunofluorescence interacting lifecycle localisation nap1 npm1 others overlapping par pathogen pcv pcv1 pcv2 porcine prominent redistribution rep swine tdg vg5q znf265
Tagcloud (Difference) ?		apathogenic aspects cap circovirus gc1qr genotypes hsp40 hybrid immunofluorescence interacting lifecycle localisation nap1 npm1 others overlapping par pathogen pcv pcv1 pcv2 porcine prominent redistribution rep swine tdg vg5q znf265
Tagcloud (Intersection) ?