MKRN1 and SLC13A1

Number of citations: 55 (PubMedID 18407958)
Data Source: BioGRID (protein complementation assay)

		MKRN1	SLC13A1
Name		makorin ring finger protein 1	solute carrier family 13 member 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytosol	Plasma Membrane Membrane Apical Plasma Membrane
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Secondary Active Sulfate Transmembrane Transporter Activity Symporter Activity Solute:sodium Symporter Activity Monoatomic Anion:sodium Symporter Activity Sodium:sulfate Symporter Activity Transmembrane Transporter Activity
	Biological Process	Protein Polyubiquitination Protein Ubiquitination	Monoatomic Ion Transport Sodium Ion Transport Sodium Ion Transmembrane Transport Transmembrane Transport Monoatomic Anion Transmembrane Transport Sulfate Transmembrane Transport
Pathways		AKT phosphorylates targets in the cytosol Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation	Sodium-coupled sulphate, di- and tri-carboxylate transporters
GWAS		Age at first birth ( 34211149 ) Age at first sexual intercourse ( 34211149 ) General risk tolerance (MTAG) ( 30643258 ) Gut microbiota relative abundance (unassigned genus belonging to family Lachnospiraceae) ( 33208821 ) Immature fraction of reticulocytes ( 32888494 ) Number of sexual partners ( 30643258 )	Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065 ) High density lipoprotein cholesterol levels ( 30498476 ) Systolic blood pressure ( 30578418 )
Interacting Genes		28 interacting genes: APC ASH2L BYSL CDKN2A CSNK1G1 DAXX DUSP23 EXOSC8 FADD FAM161A KCNH1 MAP1LC3B MTURN NAA10 OTUB2 PABPC1 RAD23A RAD23B RPS10 SDCBP SLC13A1 TSC2 UBASH3A UBE2D1 UBE2D3 UBE2D4 UBE2W YOD1	31 interacting genes: ACOT2 ACTR10 APLP2 ARL6IP1 ASS1 CD59 COQ5 COQ9 CRYAB DYNLL1 FTL GRN HSPA1A MKRN1 NDUFS5 NHERF1 NHERF2 OGDHL PDZK1 PNPLA6 PRSS8 RHOA SDHD SEC61A1 SELPLG SERPINA1 TBRG1 TM4SF1 TMED10 TP53I11 TSPAN3
Entrez ID		23608	6561
HPRD ID		09673	08394
Ensembl ID		ENSG00000133606	ENSG00000081800
Uniprot IDs		Q9UHC7	A4D0X1 Q2NKK0 Q9BZW2
PDB IDs		Not available	8W6H 8W6N 8W6O 8W6T 8Y5U 8Y5W 8Y5X 8Y5Y 8Y5Z
GO Terms Enriched among Interactors		Ubiquitin Conjugating Enzyme Activity Macromolecule Catabolic Process Cytosol Nucleus Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Response To Stress Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Protein Catabolic Process Cytoplasm Proteolysis Protein Polyubiquitination Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleoplasm Ubiquitin Protein Ligase Binding Negative Regulation Of Cyclin-dependent Protein Kinase Activity Protein K11-linked Deubiquitination TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Post-translational Protein Modification TOR Signaling Proteasome Binding Negative Regulation Of TOR Signaling Regulation Of Protein Metabolic Process Regulation Of TORC1 Signaling Ubiquitin Binding Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Cellular Response To Nutrient Levels Protein K6-linked Ubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Topologically Incorrect Protein Positive Regulation Of Viral Genome Replication Macromolecule Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Serine/threonine Kinase Activity DNA Damage Response Ligase Inhibitor Activity Cyclic Nucleotide Binding Interleukin-5 Receptor Complex Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Polyubiquitin Modification-dependent Protein Binding	Extracellular Exosome Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Vesicle Protein-membrane Adaptor Activity Sec61 Translocon Complex Ubiquinone Biosynthesis Complex Establishment Of Epithelial Cell Apical/basal Polarity Mitochondrion Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Cellular Localization ATP Metabolic Process Aerobic Electron Transport Chain Cotranslational Protein Targeting To Membrane Ubiquinone Metabolic Process Ubiquinone Biosynthetic Process Azurophil Granule Lumen Quinone Metabolic Process Establishment Of Apical/basal Cell Polarity Signaling Receptor Binding Aerobic Respiration Respiratory Electron Transport Chain Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Protein Stabilization Electron Transport Chain Cellular Respiration Membrane Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Establishment Of Epithelial Cell Polarity Mitotic Cleavage Furrow Formation Argininosuccinate Synthase Activity Argininosuccinate Metabolic Process Regulation Of Transport Protein Refolding Positive Regulation Of Aspartic-type Peptidase Activity Purine Ribonucleotide Metabolic Process Purine-containing Compound Metabolic Process Ficolin-1-rich Granule Lumen COP9 Signalosome Microvillus Membrane Tricarboxylic Acid Cycle Renal Phosphate Ion Absorption Protein Transmembrane Transporter Activity Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Pronephric Nephron Development Isoprenoid Binding