WTIP and CD2AP

Number of citations of the paper that reports this interaction (PMID 14736876)
21

Data Source:
HPRD (in vivo)

		WTIP	CD2AP
Gene Name		Wilms tumor 1 interacting protein	CD2-associated protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleus Adherens Junction	Ruffle Nucleolus Cytoplasm Plasma Membrane Cell-cell Junction Actin Cytoskeleton Filamentous Actin Extracellular Vesicular Exosome
	Molecular Function	Transcription Corepressor Activity Protein Binding Zinc Ion Binding	Structural Constituent Of Cytoskeleton Protein Binding SH3 Domain Binding
	Biological Process	Response To Hypoxia Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cytoskeleton Organization Regulation Of Cell Morphogenesis Gene Silencing By MiRNA Negative Regulation Of Hippo Signaling Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Gene Silencing By MiRNA	Protein Complex Assembly Substrate-dependent Cell Migration, Cell Extension Mitotic Nuclear Division Signal Transduction Negative Regulation Of Transforming Growth Factor Beta1 Production Cell Division Positive Regulation Of Protein Localization To Nucleus Regulation Of Actin Cytoskeleton Reorganization
Pathways			Nephrin interactions
Drugs
Diseases
GWAS			Alzheimer's disease (late onset) ( 21460841)
Protein-Protein Interactions		2 interactors: CD2AP WT1	30 interactors: BCAR1 CAPZA1 CBL CD2 CTTN FYN GRB2 GZMB HBP1 HCK HOXC11 KHDRBS1 MVB12A NPHS1 NPHS2 NR2C2 NR4A1 PDCD6IP PIK3R1 PKD2 PSTPIP1 PTGES3 RAB4A SH3GL2 SOS1 SOS2 SRC UBC WTIP YES1
Entrez ID		126374	23607
HPRD ID		19007	05026
Ensembl ID			ENSG00000198087
Uniprot IDs		A6NIX2	Q9Y5K6
PDB IDs			2FEI 2J6F 2J6K 2J6O 2J7I 3AA6 3LK4 3U23
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Positive Regulation Of Metanephric Ureteric Bud Development Thorax And Anterior Abdomen Determination Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Adrenal Cortex Formation Negative Regulation Of Glomerulus Development Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Glomerular Mesangial Cell Proliferation Zygotic Determination Of Anterior/posterior Axis, Embryo Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Female Gonad Development Cardiac Muscle Cell Fate Commitment Metanephric S-shaped Body Morphogenesis Regulation Of Glomerular Mesangial Cell Proliferation S-shaped Body Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Diaphragm Development Substrate-dependent Cell Migration, Cell Extension Positive Regulation Of Male Gonad Development Regulation Of Female Gonad Development Seminiferous Tubule Development Glomerular Basement Membrane Development Glomerular Visceral Epithelial Cell Differentiation Muscle Cell Fate Commitment Cell Motility Mesenchymal To Epithelial Transition Metanephric Mesenchyme Development Sertoli Cell Development Anterior/posterior Axis Specification, Embryo Sex Determination Cellular Response To Gonadotropin Stimulus Metanephric Nephron Morphogenesis Sertoli Cell Differentiation Male Genitalia Development Metanephric Epithelium Development Pericardium Development Metanephros Morphogenesis Locomotion Substrate-dependent Cell Migration Positive Regulation Of Kidney Development Positive Regulation Of Heart Growth Regulation Of Actin Cytoskeleton Reorganization Adrenal Gland Development Cell Differentiation Involved In Kidney Development Metanephric Nephron Development Response To Gonadotropin Movement Of Cell Or Subcellular Component	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Response To Growth Factor Neurotrophin Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune System Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Signaling Regulation Of Cellular Component Organization Cell Communication Signal Transduction Leukocyte Migration Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Regulation Of ERBB Signaling Pathway Locomotion Cellular Response To Hormone Stimulus Cellular Response To Organic Substance Blood Coagulation Hemostasis Innate Immune Response Cell Surface Receptor Signaling Pathway Cell Migration Cellular Response To Peptide Hormone Stimulus Regulation Of Immune Response Cellular Response To Peptide Cell Motility Response To Organic Substance Immune Response Regulation Of Immune System Process Regulation Of Body Fluid Levels Positive Regulation Of Organelle Organization Regulation Of Cellular Process Cellular Response To Stimulus Wound Healing Chemotaxis T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Stimulus
Tagcloud ?		ajuba coactivator conserved contributed damaged drosophila hippo homolog imply jnk jub jun lats lats1 lim limd1 link mammalian neighboring neoplastic promoted regeneration replace trigger wing wounding yap yki yorkie	abca7 bin1 cass4 cd33 celf1 chapter discoveries drb1 drb5 epha1 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b rin3 slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1
Tagcloud (Difference) ?		ajuba coactivator conserved contributed damaged drosophila hippo homolog imply jnk jub jun lats lats1 lim limd1 link mammalian neighboring neoplastic promoted regeneration replace trigger wing wounding yap yki yorkie	abca7 bin1 cass4 cd33 celf1 chapter discoveries drb1 drb5 epha1 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b rin3 slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1
Tagcloud (Intersection) ?