DDX58 and TRIM25

Number of citations of the paper that reports this interaction (PMID 23950712)
7

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		DDX58	TRIM25
Gene Name		DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	tripartite motif containing 25
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Tight Junction Actin Cytoskeleton Ruffle Membrane	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Double-stranded DNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Identical Protein Binding	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Acid-amino Acid Ligase Activity Poly(A) RNA Binding
	Biological Process	Positive Regulation Of Defense Response To Virus By Host Metabolic Process Detection Of Virus Response To Virus Viral Process Regulation Of Cell Migration Negative Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Regulation Of Type III Interferon Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus RIG-I Signaling Pathway Positive Regulation Of Transcription Factor Import Into Nucleus Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Viral Process Protein Ubiquitination Cytokine-mediated Signaling Pathway Negative Regulation Of Type I Interferon Production Response To Vitamin D Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Estrogen Innate Immune Response Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Release From Host Cell
Pathways		TRAF3-dependent IRF activation pathway RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling TRAF6 mediated IRF7 activation Cytokine Signaling in Immune system TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Antiviral mechanism by IFN-stimulated genes Innate Immune System	Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Interferon gamma signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Innate Immune System
Drugs
Diseases
GWAS			Height ( 18391951)
Protein-Protein Interactions		13 interactors: CYLD MAVS PRKCG PRKRIR RNF135 TRIM25 UBC UBE2D1 UBE2D2 UBE2D3 UBE2K USP3 WRNIP1	27 interactors: AMFR DDX58 ERCC2 ESR1 GATA1 GRIK2 MEIS2 OTUB2 PITX2 RARRES3 RBCK1 RNF31 SFN STK38 TFG TRAF6 TRIM8 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J2 UBE2L6 UBE2N USP15 USP39 ZNF24
Entrez ID		23586	7706
HPRD ID		13131	02711
Ensembl ID		ENSG00000107201	ENSG00000121060
Uniprot IDs		B3KWW1 F5H5W6 O95786	Q14258
PDB IDs		2LWD 2LWE 2QFB 2QFD 2RMJ 2YKG 3LRN 3LRR 3NCU 3OG8 3TMI 3ZD6 3ZD7 4AY2 4BPB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Type I Interferon Production Regulation Of Type I Interferon Production Response To Stress Regulation Of Innate Immune Response Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Cytokine Production Immune Response Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Defense Response Protein K48-linked Ubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Protein Polyubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Macromolecule Catabolic Process Regulation Of Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cytokine Production Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Immune System Process Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Cellular Protein Modification Process Positive Regulation Of Immune Response Response To Stimulus Regulation Of Protein Catabolic Process Regulation Of Immune System Process Cellular Response To Stimulus Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Immune System Process Cellular Response To Stress Proteolysis Regulation Of I-kappaB Kinase/NF-kappaB Signaling	Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To Organic Substance Activation Of Innate Immune Response Proteolysis Immune Response-regulating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Protein Modification Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K48-linked Ubiquitination Toll-like Receptor Signaling Pathway Immune System Process Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Signaling Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Proteasomal Protein Catabolic Process Cell Communication Response To Stimulus Cellular Response To Stimulus Regulation Of Immune System Process TRIF-dependent Toll-like Receptor Signaling Pathway Signal Transduction Cellular Metabolic Process Negative Regulation Of Gene Expression MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Transcription, DNA-templated Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Organic Substance
Tagcloud ?		adenovirus apobec3a exact expand hiv ifi27 ifi44l ifit1 ifit2 ifit3 innate irf7 isg15 isg20 isgs mdms microarray monocyte mx1 mx2 reservoirs rig rsad2 select stat1 tnfsf10 trail viperin vpr	accelerates amf autocrine catalyzes cooperates cooperative dhfr e4 erad gauges gp78 illustrated insight isomerase ligase mechanistic motility pgi phosphoglucose polyubiquitylation round steady tripartite ub ubiquitin ubiquitylates ubiquitylation uncovers vital
Tagcloud (Difference) ?		adenovirus apobec3a exact expand hiv ifi27 ifi44l ifit1 ifit2 ifit3 innate irf7 isg15 isg20 isgs mdms microarray monocyte mx1 mx2 reservoirs rig rsad2 select stat1 tnfsf10 trail viperin vpr	accelerates amf autocrine catalyzes cooperates cooperative dhfr e4 erad gauges gp78 illustrated insight isomerase ligase mechanistic motility pgi phosphoglucose polyubiquitylation round steady tripartite ub ubiquitin ubiquitylates ubiquitylation uncovers vital
Tagcloud (Intersection) ?