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DDX58 and WRNIP1
Number of citations of the paper that reports this interaction (PMID
21903422
)
33
Data Source:
BioGRID
(affinity chromatography technology, pull down)
DDX58
WRNIP1
Gene Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
Werner helicase interacting protein 1
Image
Gene Ontology Annotations
Cellular Component
Cytoplasm
Cytosol
Tight Junction
Actin Cytoskeleton
Ruffle Membrane
Nucleus
Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
Double-stranded DNA Binding
Double-stranded RNA Binding
Single-stranded RNA Binding
Helicase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Identical Protein Binding
DNA Binding
Protein Binding
ATP Binding
ATPase Activity
Identical Protein Binding
Metal Ion Binding
Biological Process
Positive Regulation Of Defense Response To Virus By Host
Metabolic Process
Detection Of Virus
Response To Virus
Viral Process
Regulation Of Cell Migration
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Regulation Of Type III Interferon Production
Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus
RIG-I Signaling Pathway
Positive Regulation Of Transcription Factor Import Into Nucleus
Response To Exogenous DsRNA
Innate Immune Response
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
DNA Synthesis Involved In DNA Repair
DNA Replication
Regulation Of DNA-dependent DNA Replication Initiation
Pathways
TRAF3-dependent IRF activation pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Negative regulators of RIG-I/MDA5 signaling
ISG15 antiviral mechanism
Interferon Signaling
TRAF6 mediated IRF7 activation
Cytokine Signaling in Immune system
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Antiviral mechanism by IFN-stimulated genes
Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
13 interactors:
CYLD
MAVS
PRKCG
PRKRIR
RNF135
TRIM25
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2K
USP3
WRNIP1
8 interactors:
ABL1
DDX58
PIN1
POLD1
POLD2
POLD4
TOLLIP
WRN
Entrez ID
23586
56897
HPRD ID
13131
10494
Ensembl ID
ENSG00000107201
ENSG00000124535
Uniprot IDs
B3KWW1
F5H5W6
O95786
Q96S55
PDB IDs
2LWD
2LWE
2QFB
2QFD
2RMJ
2YKG
3LRN
3LRR
3NCU
3OG8
3TMI
3ZD6
3ZD7
4AY2
4BPB
3VHS
3VHT
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Type I Interferon Production
Regulation Of Type I Interferon Production
Response To Stress
Regulation Of Innate Immune Response
Innate Immune Response
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Negative Regulation Of Cytokine Production
Immune Response
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Defense Response
Protein K48-linked Ubiquitination
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Ubiquitination
Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Protein Polyubiquitination
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Immune Response-regulating Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Cellular Macromolecule Catabolic Process
Regulation Of Immune Response
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Cytokine Production
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Immune System Process
Toll-like Receptor Signaling Pathway
Cellular Response To Oxygen Levels
Cellular Protein Modification Process
Positive Regulation Of Immune Response
Response To Stimulus
Regulation Of Protein Catabolic Process
Regulation Of Immune System Process
Cellular Response To Stimulus
Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Immune System Process
Cellular Response To Stress
Proteolysis
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Mismatch Repair
Base-excision Repair
Telomere Maintenance
Nucleotide-excision Repair, DNA Gap Filling
DNA-dependent DNA Replication
DNA Biosynthetic Process
Telomere Maintenance Via Semi-conservative Replication
Nuclear DNA Replication
Telomere Maintenance Via Recombination
Mitotic Recombination
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Telomere Maintenance Via Telomere Lengthening
Response To Stress
Transcription-coupled Nucleotide-excision Repair
DNA Repair
DNA Recombination
DNA Replication
Cellular Response To DNA Damage Stimulus
Nucleotide-excision Repair
DNA Metabolic Process
DNA Synthesis Involved In DNA Repair
Cell Cycle
Homeostatic Process
Cellular Response To Stimulus
Cellular Homeostasis
Cellular Response To Stress
Mitotic Cell Cycle
Innate Immune Response
Negative Regulation Of Type I Interferon Production
Negative Regulation Of ERK1 And ERK2 Cascade
Chromosome Organization
Response To Stimulus
Cell Cycle Process
DNA Replication Proofreading
Transitional One Stage B Cell Differentiation
Regulation Of Ubiquitin-protein Transferase Activity
Immune Response
Regulation Of Type I Interferon Production
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Defense Response
Regulation Of Cytokine Production
Negative Regulation Of Phospholipase C Activity
Mitochondrial Depolarization
Response To UV
Regulation Of Cell Motility
Regulation Of Growth Rate
Cellular Response To Dopamine
Nucleolus To Nucleoplasm Transport
RIG-I Signaling Pathway
Tagcloud
?
adenovirus
apobec3a
exact
expand
hiv
ifi27
ifi44l
ifit1
ifit2
ifit3
innate
irf7
isg15
isg20
isgs
mdms
microarray
monocyte
mx1
mx2
reservoirs
rig
rsad2
select
stat1
tnfsf10
trail
viperin
vpr
Tagcloud (Difference)
?
adenovirus
apobec3a
exact
expand
hiv
ifi27
ifi44l
ifit1
ifit2
ifit3
innate
irf7
isg15
isg20
isgs
mdms
microarray
monocyte
mx1
mx2
reservoirs
rig
rsad2
select
stat1
tnfsf10
trail
viperin
vpr
Tagcloud (Intersection)
?