LAMA2

Name	laminin subunit alpha 2
Structure
Interactors	4 interactors: DAG1 RPSA SNAPIN TRIM63
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Matrix Neuromuscular Junction Sarcolemma Synaptic Cleft Dendritic Spine Protein Complex Involved In Cell-matrix Adhesion
	Molecular Function	Signaling Receptor Binding Structural Molecule Activity Extracellular Matrix Structural Constituent
	Biological Process	Cell Adhesion Axon Guidance Muscle Organ Development Schwann Cell Differentiation Regulation Of Cell Adhesion Regulation Of Cell Migration Positive Regulation Of Synaptic Transmission, Cholinergic Maintenance Of Blood-brain Barrier Positive Regulation Of Cell Adhesion Regulation Of Embryonic Development Positive Regulation Of Muscle Cell Differentiation Regulation Of Basement Membrane Organization Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways	Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans MET activates PTK2 signaling EGR2 and SOX10-mediated initiation of Schwann cell myelination Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells
Diseases	Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS	Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Appendicular lean mass ( 33097823 ) Axial length ( 24144296 ) Body mass index ( 20397748 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Height ( 31562340 ) High myopia ( 33830181 31816047 ) Hyperopia ( 25233373 33830181 ) Low myopia vs hyperopia ( 33830181 ) Metabolite levels ( 23823483 ) Myopia ( 25233373 27182965 ) Night sleep phenotypes ( 27126917 ) Periodontal disease-related phenotype (Socransky) ( 24347629 ) Refractive error ( 23396134 ) Retinal detachment or retinal break ( 31816047 ) Serum bilirubin levels x Mediterranean diet adherence interaction in metabolic syndrome ( 30621171 ) Sleep duration (short sleep) ( 30846698 ) Smoking status (ever vs never smokers) ( 30643258 ) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Tea consumption ( 31046077 )
Entrez ID	3908
HPRD ID	01125
Ensembl ID	ENSG00000196569
Uniprot IDs	A0A087WYF1 P24043 Q59H37
PDB IDs	4YEP 4YEQ
GO Terms Enriched among Interactors ?	Laminin Binding Muscle Attachment Symbiont Entry Into Host Cell Virus Receptor Activity Positive Regulation Of Late Endosome To Lysosome Transport Calcium-dependent Cell-matrix Adhesion Biological Process Involved In Interaction With Host Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex Nerve Maturation Developmental Maturation Protein Metabolic Process Laminin Receptor Activity Response To Denervation Involved In Regulation Of Muscle Adaptation Trans-synaptic Signaling By Trans-synaptic Complex Laminin-1 Binding Schwann Cell Differentiation Photoreceptor Ribbon Synapse Dystroglycan Complex Contractile Ring Terminal Button Organization Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Response To Muscle Inactivity Synaptic Vesicle Maturation Regulation Of Lysosome Size BORC Complex Microvesicle Muscle Atrophy Dystroglycan Binding Trans-synaptic Signaling Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Branching Involved In Salivary Gland Morphogenesis Costamere Vinculin Binding Cellular Response To Sterol Dystrophin-associated Glycoprotein Complex Neuron Projection Development Node Of Ranvier Schwann Cell Development Nuclear Periphery Skeletal Muscle Tissue Regeneration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Commissural Neuron Axon Guidance Angiogenesis Involved In Wound Healing Axon Regeneration Morphogenesis Of An Epithelial Sheet Positive Regulation Of Myelination Alpha-actinin Binding