RIMBP2 and CACNA1A

Number of citations of the paper that reports this interaction (PubMedID 21078624)
125

Data Source:
BioGRID (two hybrid)

		RIMBP2	CACNA1A
Description		RIMS binding protein 2	calcium voltage-gated channel subunit alpha1 A
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GO Annotations	Cellular Component	Plasma Membrane Membrane Synapse	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Cell Projection Neuronal Cell Body Synapse
	Molecular Function	Protein Binding	Amyloid-beta Binding Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding
	Biological Process	Neuromuscular Synaptic Transmission	Monoatomic Ion Transport Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Transmembrane Transport Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane Response To Amyloid-beta Cellular Response To Amyloid-beta
Pathways			Presynaptic depolarization and calcium channel opening Regulation of insulin secretion
Drugs			Ergocalciferol Enflurane Phenytoin Spironolactone Nicardipine Magnesium sulfate Verapamil Verapamil Levomenthol Loperamide Nitrendipine Bepridil Ziconotide Dotarizine Drotaverine Trimebutine Benidipine Cilnidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Bioallethrin
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Episodic ataxias Familial or sporadic hemiplegic migraine
GWAS		Alcohol dependence symptom count ( 29460428) Breast cancer and/or colorectal cancer ( 29698419) Bronchopulmonary dysplasia in preterm infants ( 30113228) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Lifespan ( 25918517) Psychosis and Alzheimer's disease ( 22005930) Refractive error ( 32231278)	Exfoliation syndrome ( 25706626) Proteinuria and chronic kidney disease ( 26420894)
Interacting Genes		3 interacting genes: CACNA1A NAA10 NEAT1	92 interacting genes: ABCA2 ABI1 ACTN1 ADGRL1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 BTG3 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GET3 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TSPOAP1 TUBB2B UQCRC2 VARS1 VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233
Entrez ID		23504	773
HPRD ID		17183	03004
Ensembl ID		ENSG00000060709	ENSG00000141837
Uniprot IDs		A0A2R8Y6Z0 A0A8I5KQF3 A0A8I5KWW4 A0A8I5QJU8 A0A9L9PY66 O15034	A0A087WW63 B5TYJ1 O00555 Q9NS89
PDB IDs		1WIE 2CSI 2CSP 2CSQ	3BXK 8X90 8X91 8X93
Enriched GO Terms of Interacting Partners?		Regulation Of Centromeric Sister Chromatid Cohesion Protein-N-terminal-alanine Acetyltransferase Activity Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Negative Regulation Of Sister Chromatid Cohesion Protein N-terminal-serine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity NatA Complex RISC Complex Binding Positive Regulation Of Synoviocyte Proliferation MiRNA Inhibitor Activity Via Base-pairing LncRNA-mediated Post-transcriptional Gene Silencing Protein-N-terminal Amino-acid Acetyltransferase Activity Positive Regulation Of MiRNA Catabolic Process Internal Protein Amino Acid Acetylation Paraspeckles Regulation Of MRNA Export From Nucleus N-terminal Protein Amino Acid Acetylation High Voltage-gated Calcium Channel Activity N-acetyltransferase Activity Regulation Of Sister Chromatid Cohesion Chromatin-protein Adaptor Activity Nuclear Body Organization Regulation Of RNA Export From Nucleus Acetyltransferase Activity Calcium Ion Import Across Plasma Membrane Calcium Ion Import Into Cytosol Voltage-gated Calcium Channel Complex Voltage-gated Calcium Channel Activity Protein Acetylation Calcium Ion Import MiRNA Binding Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Syntaxin Binding Cellular Response To Amyloid-beta Molecular Condensate Scaffold Activity Response To Amyloid-beta Positive Regulation Of MiRNA Metabolic Process Ribosome Binding	Calcium Ion Binding Extracellular Matrix Structural Constituent Extracellular Matrix Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Embryo Implantation Calcium Channel Regulator Activity Basement Membrane Microfibril Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels Detection Of Calcium Ion Auditory Receptor Cell Fate Commitment Protein Binding Calyx Of Held Integrin Binding Astrocyte Activation Involved In Immune Response Transforming Growth Factor Beta Binding Extracellular Region Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Elastic Fiber Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Inhibitor Activity Low-density Lipoprotein Particle Receptor Binding Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Presynaptic Cytosol Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Population Proliferation Regulation Of Extracellular Matrix Organization Regulation Of Alternative MRNA Splicing, Via Spliceosome
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