MELK and EIF2S1

Number of citations of the paper that reports this interaction (PubMedID 16216881)
0

Data Source:
HPRD (in vivo)

		MELK	EIF2S1
Description		maternal embryonic leucine zipper kinase	eukaryotic translation initiation factor 2 subunit alpha
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Cortex Membrane	Nucleus Cytoplasm Mitochondrion Cytosol Eukaryotic Translation Initiation Factor 2 Complex Cytoplasmic Stress Granule Membrane Eukaryotic 48S Preinitiation Complex Translation Initiation Ternary Complex Synapse Extracellular Exosome Glial Limiting End-foot
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Lipid Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleic Acid Binding RNA Binding Translation Initiation Factor Activity Protein Binding Ribosome Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Apoptotic Process Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Hemopoiesis Positive Regulation Of Apoptotic Process Protein Autophosphorylation Neural Precursor Cell Proliferation	Mitophagy Translation Translational Initiation Regulation Of Translation Negative Regulation Of Translational Initiation In Response To Stress Stress Granule Assembly Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To UV Response To Endoplasmic Reticulum Stress Regulation Of Translation In Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Regulation Of Translational Initiation In Response To Stress Mitochondrial Respirasome Assembly HRI-mediated Signaling Response To Kainic Acid Response To Manganese-induced Endoplasmic Reticulum Stress Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency PKR-mediated signaling Cellular response to mitochondrial stress
Drugs		Fostamatinib
Diseases
GWAS
Interacting Genes		11 interacting genes: CDC25B CDC5L EIF2S1 EZH2 H1-5 LMNB1 MAPT MBP PPP1R8 SF3B1 ZNF622	28 interacting genes: ACTN1 ANXA1 CASP3 CASP6 CDC37 CEBPA CSNK2A1 EIF1AX EIF2AK1 EIF2AK2 EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2S2 HSP90AA1 HSPB1 MELK P4HB PPP1R15A PRKCA PRKCD PRMT7 SFN TERT THAP12 VAC14
Entrez ID		9833	1965
HPRD ID		06119	04881
Ensembl ID		ENSG00000165304	ENSG00000134001
Uniprot IDs		B7Z1G6 Q14680	P05198 Q53XC0
PDB IDs		4BKY 4BKZ 4BL1 4D2P 4D2T 4D2V 4D2W 4IXP 4UMP 4UMQ 4UMR 4UMT 4UMU 5IH8 5IH9 5IHA 5IHC 5K00 5M5A 5MAF 5MAG 5MAH 5MAI 5TVT 5TWL 5TWU 5TWY 5TWZ 5TX3 6GVX 6VXR 9F31	1KL9 1Q8K 6K71 6K72 6O81 6O85 6O9Z 6YBV 6ZMW 6ZP4 7A09 7D43 7D44 7D45 7F66 7F67 7NZM 7QP6 7QP7 7SYR 7SYS 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PPL 8QZZ
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleus Nuclear Periphery Double-stranded DNA Binding Spliceosomal Complex Nucleoplasm Stress Granule Assembly Translation Initiation Ternary Complex Cellular Response To Chemical Stress Cellular Response To Heat Cellular Response To Oxidative Stress Hepatocyte Homeostasis Chromatin Remodeling Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Positive Regulation Of Metalloendopeptidase Activity Ribonuclease E Activity U11/U12 SnRNP Positive Regulation Of Catalytic Activity RNA Splicing Catalytic Step 2 Spliceosome Response To Heat Response To Oxidative Stress Chromatin DNA Binding Cellular Response To Trichostatin A Chromatin Organization Structural Constituent Of Nuclear Lamina Neurofibrillary Tangle Assembly Nuclear Speck Regulation Of Gene Expression MRNA Processing Regulation Of Cell Cycle Phase Transition Regulation Of Metabolic Process Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Response To Manganese-induced Endoplasmic Reticulum Stress Glial Limiting End-foot Response To Kainic Acid Eukaryotic Translation Initiation Factor 2 Complex Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Positive Regulation Of Hydrolase Activity Cellular Response To Reactive Oxygen Species Histone H3K27 Trimethyltransferase Activity Response To Tetrachloromethane Regulation Of Metallopeptidase Activity Internode Region Of Axon Compact Myelin Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translational Initiation In Response To Stress	Translational Initiation Eukaryotic Translation Initiation Factor 2B Complex Translation Initiation Factor Activity Cytosol Regulation Of Translational Initiation Response To Stress Post-transcriptional Regulation Of Gene Expression Cytoplasmic Translational Initiation Protein Metabolic Process Response To Temperature Stimulus Response To Heat Regulation Of Apoptotic Process Regulation Of Translation Regulation Of Programmed Cell Death Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Regulation Of Protein Metabolic Process Response To Hormone Regulation Of Immune System Process Signal Transduction Oligodendrocyte Development Positive Regulation Of Immune System Process Intrinsic Apoptotic Signaling Pathway Macromolecule Metabolic Process Apoptotic Signaling Pathway Translation Protein Serine Kinase Activity Regulation Of Immune Response Intracellular Signal Transduction Response To Glucose Cellular Response To Stress Response To Monosaccharide Protein Serine/threonine Kinase Activity Glial Cell Development Activation Of Immune Response Translation Factor Activity, RNA Binding Response To Carbohydrate Cell Development Protein Kinase C Inhibitor Activity Positive Regulation Of Immune Response Identical Protein Binding Response To Peptide Hormone Cytoplasm Regulation Of Gene Expression Regulation Of Stem Cell Proliferation Negative Regulation Of Translation Protein Kinase Activity Regulation Of Macromolecule Biosynthetic Process Cellular Response To Staurosporine Protein Kinase C Signaling Protein Folding
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