MELK and LMNB1

Number of citations of the paper that reports this interaction (PubMedID 16216881)
0

Data Source:
HPRD (in vivo)

		MELK	LMNB1
Description		maternal embryonic leucine zipper kinase	lamin B1
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Cortex Membrane	Nucleus Nuclear Envelope Nuclear Inner Membrane Lamin Filament Nuclear Lamina Nucleoplasm Intermediate Filament Membrane Nuclear Matrix Nuclear Membrane Nuclear Periphery
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Lipid Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Double-stranded DNA Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipase Binding Structural Constituent Of Nuclear Lamina Sequence-specific Double-stranded DNA Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Apoptotic Process Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Hemopoiesis Positive Regulation Of Apoptotic Process Protein Autophosphorylation Neural Precursor Cell Proliferation	Nuclear Envelope Organization Cytoskeleton Organization Nuclear Migration Heterochromatin Formation Nuclear Pore Localization Protein Localization To Nuclear Envelope
Pathways			Meiotic synapsis Formation of Senescence-Associated Heterochromatin Foci (SAHF) Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Breakdown of the nuclear lamina Depolymerization of the Nuclear Lamina Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation RHOD GTPase cycle RHOF GTPase cycle
Drugs		Fostamatinib
Diseases
GWAS			Blood protein levels ( 30072576) Body fat percentage ( 31752434) Parkinson's disease (motor and cognition) ( 22658654)
Interacting Genes		11 interacting genes: CDC25B CDC5L EIF2S1 EZH2 H1-5 LMNB1 MAPT MBP PPP1R8 SF3B1 ZNF622	42 interacting genes: ABCG8 ATF4 CASP3 CASP6 CCDC88B CDK1 CENPH DMAP1 FAM169A GABARAP GIT2 GZMA GZMB KPNA5 KPNA6 LBR LMNA M1AP MAP1LC3A MAP1LC3C MBIP MELK PIAS2 PIH1D2 PLEC PPP1R13B PRKCA PRKCB PRKCD PRPH PTEN RNF123 SERPINA3 SNAPIN SRPK2 SUMO4 TMPO TOR1AIP1 TP53BP2 UBE2I URB2 YWHAQ
Entrez ID		9833	4001
HPRD ID		06119	01036
Ensembl ID		ENSG00000165304	ENSG00000113368
Uniprot IDs		B7Z1G6 Q14680	B4DZT3 P20700
PDB IDs		4BKY 4BKZ 4BL1 4D2P 4D2T 4D2V 4D2W 4IXP 4UMP 4UMQ 4UMR 4UMT 4UMU 5IH8 5IH9 5IHA 5IHC 5K00 5M5A 5MAF 5MAG 5MAH 5MAI 5TVT 5TWL 5TWU 5TWY 5TWZ 5TX3 6GVX 6VXR 9F31	2KPW 3JT0 3TYY 3UMN 5BNW 5VVX 7DTG
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleus Nuclear Periphery Double-stranded DNA Binding Spliceosomal Complex Nucleoplasm Stress Granule Assembly Translation Initiation Ternary Complex Cellular Response To Chemical Stress Cellular Response To Heat Cellular Response To Oxidative Stress Hepatocyte Homeostasis Chromatin Remodeling Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Positive Regulation Of Metalloendopeptidase Activity Ribonuclease E Activity U11/U12 SnRNP Positive Regulation Of Catalytic Activity RNA Splicing Catalytic Step 2 Spliceosome Response To Heat Response To Oxidative Stress Chromatin DNA Binding Cellular Response To Trichostatin A Chromatin Organization Structural Constituent Of Nuclear Lamina Neurofibrillary Tangle Assembly Nuclear Speck Regulation Of Gene Expression MRNA Processing Regulation Of Cell Cycle Phase Transition Regulation Of Metabolic Process Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Response To Manganese-induced Endoplasmic Reticulum Stress Glial Limiting End-foot Response To Kainic Acid Eukaryotic Translation Initiation Factor 2 Complex Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Positive Regulation Of Hydrolase Activity Cellular Response To Reactive Oxygen Species Histone H3K27 Trimethyltransferase Activity Response To Tetrachloromethane Regulation Of Metallopeptidase Activity Internode Region Of Axon Compact Myelin Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translational Initiation In Response To Stress	Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Cell Death Apoptotic Process Programmed Cell Death Nuclear Membrane Organization Protein Kinase C Signaling Cellular Response To Nitrogen Starvation Intracellular Signal Transduction Mitotic Nuclear Membrane Disassembly Membrane Organization Cytoplasm Cellular Response To Chemical Stress Pyroptotic Inflammatory Response Phosphatidylethanolamine Binding Nuclear Membrane Disassembly Nuclear Inner Membrane Histone H3T6 Kinase Activity Autophagosome Maturation Membrane Disassembly Lamin Binding Nucleoplasm Diacylglycerol-dependent Serine/threonine Kinase Activity Cytosol Nuclear Envelope Response To Stress Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Response To Oxidative Stress Nucleus Regulation Of Programmed Cell Death Intracellular Signaling Cassette Cellular Response To Staurosporine SUMO Ligase Complex Regulation Of Protein Localization To Nucleus Positive Regulation Of Apoptotic Process Response To Reactive Oxygen Species Positive Regulation Of Programmed Cell Death Nucleus Organization Response To Hydrogen Peroxide Protein Maturation Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Import Into Nucleus Regulation Of Endodeoxyribonuclease Activity Cardiac Muscle Cell Development Cellular Response To Oxidative Stress Cardiac Cell Development Protein Phosphorylation Protein Serine Kinase Activity
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