MELK and LMNB1

Number of citations of the paper that reports this interaction (PMID 16216881)
21

Data Source:
HPRD (in vivo)

		MELK	LMNB1
Gene Name		maternal embryonic leucine zipper kinase	lamin B1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell Cortex Membrane	Nuclear Envelope Nuclear Inner Membrane Lamin Filament Nucleoplasm Membrane Nuclear Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Lipid Binding	Structural Molecule Activity Phospholipase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Apoptotic Process Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Peptidyl-tyrosine Phosphorylation Hemopoiesis Positive Regulation Of Apoptotic Process Protein Autophosphorylation Neural Precursor Cell Proliferation	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Pathways			Apoptotic cleavage of cellular proteins DNA Damage/Telomere Stress Induced Senescence Mitotic Prophase Apoptotic execution phase Cellular Senescence Meiotic synapsis Depolymerisation of the Nuclear Lamina Nuclear Envelope Breakdown Clearance of Nuclear Envelope Membranes from Chromatin Mitotic Anaphase M Phase Cell Cycle, Mitotic Formation of Senescence-Associated Heterochromatin Foci (SAHF) Programmed Cell Death Breakdown of the nuclear lamina Nuclear Envelope Reassembly Initiation of Nuclear Envelope Reformation Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS			Parkinson's disease (motor and cognition) ( 22658654)
Protein-Protein Interactions		9 interactors: CDC25B CDC5L EIF2S1 HIST1H1B LMNB1 MBP PPP1R8 SF3B1 ZNF622	23 interactors: ABCG8 ATF4 CASP3 CASP6 CDK1 GIT2 GZMA GZMB LBR LMNA MBIP MELK PLEC PRKCA PRKCB PRKCD PRPH SERPINA3 SUMO4 TMPO TOR1AIP1 URB2 YWHAQ
Entrez ID		9833	4001
HPRD ID		06119	01036
Ensembl ID		ENSG00000165304	ENSG00000113368
Uniprot IDs		B7Z1G6 Q14680	B4DZT3 P20700
PDB IDs		4BKY 4BKZ 4BL1 4IXP	2KPW 3JT0 3TYY 3UMN
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing Positive Regulation Of Kinase Activity MRNA Metabolic Process Positive Regulation Of Transferase Activity RNA Processing Defense Response To Nematode	Apoptotic Process Programmed Cell Death Cell Death Death Intrinsic Apoptotic Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Nuclear Envelope Organization Execution Phase Of Apoptosis Apoptotic Signaling Pathway Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly Nucleus Organization Peptidyl-threonine Phosphorylation Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Histone H3-T6 Phosphorylation Positive Regulation Of Cell Death Cellular Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Protein Serine/threonine Kinase Activity Histone Phosphorylation Peptidyl-amino Acid Modification Intracellular Signal Transduction Positive Regulation Of Hydrolase Activity Regulation Of Insulin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Negative Regulation Of Glial Cell Apoptotic Process Response To Oxidative Stress Positive Regulation Of Catalytic Activity Endomembrane System Organization Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase Activity Neurotrophin Signaling Pathway Negative Regulation Of Kinase Activity Negative Regulation Of Catalytic Activity Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of MAP Kinase Activity Regulation Of Mitochondrion Organization Regulation Of Platelet Aggregation Membrane Organization Negative Regulation Of Glucose Transport Regulation Of Phosphorylation Regulation Of MAP Kinase Activity
Tagcloud ?		axis caenorhabditis catalytic coexpressed collectively contributes driven elegans evolutionarily ezh2 foxm1 gbm glioblastoma gsc gscs inversely irradiation mitotic oncogenic phosphorylates polycomb possibility postirradiation radioresistance raise repressive serve tumorigenic turn	cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lcp1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars
Tagcloud (Difference) ?		axis caenorhabditis catalytic coexpressed collectively contributes driven elegans evolutionarily ezh2 foxm1 gbm glioblastoma gsc gscs inversely irradiation mitotic oncogenic phosphorylates polycomb possibility postirradiation radioresistance raise repressive serve tumorigenic turn	cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lcp1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars
Tagcloud (Intersection) ?